Oya GÖKMEN, Sertaç BATIOĞLU, Berna SEÇKİN, Hulusi Bülent ZEYNELOĞLU

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Effect of Initiation Day of Clomiphene Citrate Treatment on Endometrium and Cervical Mucus

Amaç: Siklusun farklı günlerinde klomifen sitrat (CC) tedavisi başlanan hastalarda, klomifen sitratın reprodüktif organlardaki antiöstrojenik etkisini kıyaslamak. Hastalar ve Yöntemler: Klomifen sitratla ovulasyon indüksiyonu yapılan toplam 95 hasta, bu prospektif randomize kontrollü çalışmaya dahil edildi. Hastalar 2 gruba ayrıldı: 3. gün grubuna (n=52), siklusun 3-7. günlerinde, 5. gün grubuna ise (n=43) siklusun 5-9. günlerinde, toplam 5 gün CC verildi. Antiöstrojenik etkiler; endometrial kalınlık ve servikal mukus kalitesi, siklus karakteristikleri ve tedavi sonuçları değerlendirildi. Antiöstrojenik etkileri incelemek için, sadece ovulatuar sikluslara ait veriler analiz edildi. Bulgular: 3. gün grubundaki 44, 5. gün grubundaki 34 hasta antiöstrojenik etkiler için değerlendirildi. İnsan Koryonik Gonadotropin (hCG) yapılma günündeki endometrial kalınlık her iki grupta benzerdi. 3. gün grubunda ortalama servikal mukus skoru daha düşük bulundu (8.1±2.7 vs. 9.7±2.3, p=0.036). Gruplar arasında, hCG günündeki serum estradiol (E2), progesteron, önde giden follikül sayısı, siklus başına ovulasyon ve gebelik oranları açısından anlamlı farklılık izlenmedi. Sonuç: Endometrial kalınlık, siklusun 3. veya 5. günü CC başlanan hastalar arasında farklılık göstermemektedir. Bununla birlikte, servikal mukus kalitesi, 3. gün CC başlananlarda, 5. gün başlananlara göre daha kötü olabilmektedir.

KLOMİFEN SİTRAT TEDAVİ BAŞLANGIÇ GÜNÜNÜN ENDOMETRİUM VE SERVİKAL MUKUSA ETKİSİ

Objective: To compare the antiestrogenic effects of clomiphene citrate (CC) on reproductive end organs in patients where CC was started on different days of the cycle. Patients and Methods: A total of 95 patients who underwent ovulation induction with CC were initially included in this prospective randomized controlled study. Patients were divided into two treatment groups: in day 3 group (n=52), CC was given from day 3 to 7 of the cycle for five days, whereas in day 5 group (n=43), CC was given on days 5 to 9. The antiestrogenic effects of CC in terms of endometrial thickness and cervical mucus quality, cycle characteristics, and treatment outcomes were assessed. To observe possible differences in antiestrogenic effects, only data from ovulatory cycles were analyzed. Results: Fourty-four patients in the day 3 group and 34 patients in the day 5 group were analyzed. Endometrial thickness was similar in both groups on the day of human chorionic gonadotropin (hCG). In the day 3 group, the mean cervical mucus score was lower (8.1±2.7 vs. 9.7±2.3, p=0.036). There were no significant differences between the groups in the mean serum estradiol (E2), progesterone levels, and the number of leading follicles on the day of hCG, and ovulation and pregnancy rates per cycle. Conclusion: Endometrial thickness does not differ whether starting CC on day 3 or 5 of the cycle. Nevertheless, poor cervical mucus quality may be more common in the patients where CC was started on day 3 of the cycle compared to day 5.
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Acıbadem Üniversitesi Sağlık Bilimleri Dergisi-Cover
  • ISSN: 1309-470X
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 2010
  • Yayıncı: ACIBADEM MEHMET ALİ AYDINLAR ÜNİVERSİTESİ
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Effect of Initiation Day of Clomiphene Citrate Treatment on Endometrium and Cervical Mucus

Oya GÖKMEN, Sertaç BATIOĞLU, Berna SEÇKİN, Hulusi Bülent ZEYNELOĞLU