Taha Gökmen ÜLGER, Funda Pınar ÇAKIROĞLU

C Vitamini Desteğinin Diabetes Mellitus ile İlişkili Metabolik Anormallikler Üzerindeki Etkileri

Eksojen antioksidan takviyesinin, diyabetin mikro ve makrovasküler komplikasyonlarına karşı faydalı olabileceği bilinmektedir. Bu çalışmada C vitamini desteğinin, diyabetik ratlarda, kronik hiperglisemiye bağlı olarak bozulan insülin sekresyonu, hiperlipidemi, oksidatif stres ve paraoksonaz-1 enzim (PON1) aktivitesi üzerine etkilerinin araştırılması amaçlanmıştır. Bu amaçla, yirmi dört adet Wistar albino cinsi rat C, DC ve DCC grupları olarak 3 gruba ayrıldı. DC ve DCC grubundaki ratlarda, tek doz streptozotosin enjeksiyonu ile diyabet oluşturuldu (45 mg/kg). C ve DC grubundaki ratlar standart rat yemi (C vitamini içermeyen) ile beslenirken, DCC grubundaki ratlar 200 mg/kg dozunda C vitamini ile desteklenmiş deneysel yemle beslendi. Elde edilen bulgulara göre, C grubundaki ratların sekiz haftalık deney süresinin sonunda diyabetik ratlara göre daha az yem ve su tükettiği görüldü (p

Effects of Vitamin C Supplementation on the Metabolic Abnormalities Associated with Diabetes Mellitus

It is known that exogenous antioxidant supplementation may be beneficial against micro and macrovascular complications of diabetes. This study aimed to investigate the effect of vitamin C supplementation on insulin secretion, hyperlipidemia, oxidative stress and paraoxonase-1 enzyme (PON1) activity which are impaired due to chronic hyperglycemia in diabetic rats. For this purpose, twenty-four Wistar albino rats were divided into 3 groups as group C, DC and DCC. The rats in DC and DCC groups were induced diabetes by single dose streptozotocin injection (45 mg/kg). C and DC groups fed with standard rat diet (vitamin C free), DCC group fed with experimental diet supplemented with vitamin C at a dose of 200 mg/kg. According to the findings, rats in group C consumed less feed and water compared to diabetic rats during 8-weeks experimental period (p

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