Serozal Tutulumlu Eozinofilik Gastroenterit ve Siklik Nötropeni

Eozinofilik gastroenterit gastrointestinal kanalın farklı alanlarının eozinofilik infiltrasyonuna bağlı olarak farklı klinik tabloların görüldüğü nedeni bilinmeyen bir hastalıktır. Eozinofilik gastroenteritin seyrinde görülen hematolojik bulgu sadece eozinofilidir. Biz eozinofilik gastroenterit ve eozinofilik asit nedeniyle değerlendirilen ve siklik nötropeni görülen bir hastayı sunduk. Her ne kadar siklik nötropeni solid organ veya hematolojik malignensileri desteklerse de steroid tedavisi ile asit, nötropeni ve periferal eozinofilide düzelme olması tablonun eozinofilik gastroenterite bağlı olduğunu doğrulamıştır. Eozinofilik gastroenteritin seyrinde siklik nötropeni görülebileceği akılda tutulmalıdır.

Eosinophilic Gastroenteritis With Serosal Involvement and Cyclic Neutropenia

Eosinophilic gastroenteritis is a disease of unknown etiology presenting with different clinical pictures due to eosinophilic infiltration of different areas in gastrointestinal tractus. Eosinophilia is the sole hematologic finding seen in the course of eosinophilic gastroenteritis. We presented a case evaluated for eosinophilic ascites and diagnosed as eosinophilic gastroenteritis in which cyclic neutropenia was seen. Although cyclic neutropenia suggests solid organ or hematologic malignancy no sign of malignancy on investigations, improvement in ascites, peripheral eosinophilia and neutropenia with steroid therapy confirmed that this picture was completely due to eosinophilic gastroenteritis. It should be kept in mind that cyclic neutropenia may be seen during the course of eosinophilic gastroenteritis.

___

  • 1. Fenoglio LM, Benedetti V, Rossi C, Anania A, Wulhfard K, Trapani M, Scalabrino E, Alberto G, Novero D, Cavalloperin P. Eosinophilic Gastroenteritis with Ascites A Case Report and Review of the Literature. Dig Dis Sci 2003; 48(5): 1013- 1020.
  • 2. Caldwell JH, Mekhjian HS, Hurtubise PE, Beman FM. Eosinophilic gastroenteritis with obstruction. Immunological studies of seven patients. Gastroenterology 1978; 74: 825-828.
  • 3. Talley NJ, Shorter RG, Phillips SF, Zinsmeister AR. Eosinophilic gastroenteritis: a clinicopathological study of patients with disease of the mucosa, muscle layer, and subserosal tissues. Gut 1990; 31: 54-58.
  • 4. Miyamoto T, Shibata T, Matsuura S, Kagesawa M, Ishizawa Y, Tamiya K. Eosinophilic Gastroen-teritis with Ileus and Ascites. Internal Medicine 1996; 35: 779-782.
  • 5. Zhou HB, Chen JM, Du Q. Eosinophilic gastroenteritis with ascites and hepatic dysfunction. World J Gastroenterol 2007; 13(8): 1303-1305.
  • 6. Van Hoe L, Vanghillewe K, Baert AL, Ponette E, Geboes K, Stevens E. CT findings in nonmucosal eosinophilic gastroenteritis. J Comput Assist Tomogr 1994; 18: 818.
  • 7. Klein NC, Hargrove RL, Sleisenger MH, Jeffries GH. Eosinophilic gastroenteritis. Medicine 1970; 49: 299-319.
  • 8. Lee CM, Changchien CS, Chen PC, Lin DY, Sheen IS, Wang CS, Tai DI, Sheen-Chen SM, Chen WJ, Wu CS. Eosinophilic gastroenteritis: 10 years experience. Am J Gastroenterol 1993; 88: 70- 74.
  • 9. Zheng X, Cheng J, Pan K, Yang K, Wang H, Wu E. Eosinophilic enteritis: CT features. Abdom Imaging 2008; 33: 191-195.
Abant Tıp Dergisi-Cover
  • Yayın Aralığı: Yılda 6 Sayı
  • Başlangıç: 2012
  • Yayıncı: Bolu Abant İzzet Baysal Üniversitesi Tıp Fakültesi Dekanlığı