Hatice Rana ERDEM, Bünyamin KOÇ, Barış NACIR

Lomber disk herniasyonunda neovaskülarizasyonla ilişkili rezorbsiyon mekanizmaları

Lomber disk herniasyonu LDH bel ağrısı ve siyatiğin önemli bir nedenidir. LDH’nın magnetik rezonans görüntüleme MRG ile incelenmesi neo-vaskülarizasyonla ilişkili rezorbsiyon mekanizmasını ortaya çıkarmıştır. Aktive makrofajların disk dokusuyla etkileşimlerinin infamatuvar sitokinlerin üretimine yol açtığı gösterilmiştir. Buna ek olarak tümör nekrozis faktör-α TNF-α gibi infamatuvar sitokinler, vasküler endotelyal growt faktör VEGF gibi anjiogenezi uyaran faktörlerin indüksiyonu için gereklidir. VEGF endotel hücresine özgü bir mitojendir ve yeni kan damarlarının oluşumunda esaslı bir rolü vardır. Yeni oluşmuş kan damarları ve makrofaj infiltrasyonu LDH rezorbsiyonu sırasında önemli bir rol oynarlar. Bu derlemede LDH’da rezorbsiyon mekanizmaları hakkındaki güncel bilgiler özetlendi.

Anahtar Kelimeler:

Hernie disk, bel ağrısı, vasküler endotelyal growt faktör VEGF, rehabilitasyon

Resorption mechanisms related with neo-vascularization for the lomber disc herniation

Lomber disc herniation LDH is a major cause of low back pain and sciatica. MRI investigation of LDH has revealed a resorption mechanism related with neo-vascularization. It has shown that the interaction of activated macrophages with disc tissues leads to the generation of inflammatory cytokines. In addition, inflammatory cytokines such as tumor necrosis factor-α TNF-α is required for the induction of angiogenesis stimulating factors such as vascular endothelial growth factor VEGF . VEGF is an endothelial cell-specific mitogen, and it has an essential role in the formation of new blood vessels. The newly formed vessels and infiltrating macrophages play an important role during LDH resorption. In this review, recent knowledge on the resorbtion mechanisms of LDH is summerized.

Keywords:

Herniated disc, low back pain, vascular endothelial growth factor VEGF, rehabilitation,

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