Adnan GÜCÜK, Eray KEMAHLI, Uğur ÜYETÜRK, Hesna Müzeyyen ASTARCI, Gülzade ÖZYALVAÇLI, Mehmet Emin ÖZYALVAÇLI

Kas İnvaziv Olmayan Mesane Karsinomlu Hastalarda Klinikopatolojik Parametrelerin Rekürrens ve Progresyonla İlişkisi

Amaç: Bu çalışmada Abant İzzet Baysal Üniversitesi AİBÜ Tıp Fakültesi’nde ilk tanısı pTa ve pT1 transisyonel hücreli mesane karsinomlu hastalarda evre ve grade gibi histopatolojik parametrelerin yanısıra yaş, tümör boyutu, tümör sayısı ve reTUR gibi klinik verilerin rekürrens ve progresyonla ilişkisinin ortaya konması amaçlanmıştır. Yöntem: 2008-2013 yılları arasındaki Abant İzzet Baysal Üniversitesi’nde ilk transüretral rezeksiyon TUR sonrası patolojik tanısı transizyonel hücreli mesane kanseri olarak rapor edilen pTa, pT1 ardışık 119 hasta retrospektif olarak değerlendirildi. Bu hastalara ait klinik veriler ve histopatolojik preparatlar AİBÜ Üroloji ve Patoloji A.D. arşivinden elde edildi. Bulgular: Çalışmamıza dahil edilen hastaların 109’u erkek, 10’u bayandı. Ortalama takip süresi 30.14ay 2.86-80.74 idi. Univariate analizinde rekürrens ile tümör boyutu, grade’i, evresi, sayısı, Re-TUR ve sigara kullanımı arasında istatistiki fark varken progresyon ile tümör grade’i, boyutu, sayısı ve sigara kullanımı arasında istatistiki fark vardı. Multivariate analizde rekürrensi belirlemede bağımsız prediktif faktörler tümör boyutu OR: 5.26,%95CI: 1.42-19.55 ve sigara kullanımı OR: 4.65,%95CI: 1.23- 17.53 iken progresyonu belirlemede sadece tümör grade’i saptandı OR: 5.32,%95CI 1.37-20.59 . Kaplan Meier analizinde tümör boyutu

Anahtar Kelimeler:

Mesane karsinomu, grade, evre, rekürrens, progresyon

The Association Between the Clinicopathological Characteristics and the Recurrence and Progression in Patients with Non-Muscle Invasive Bladder Cancer

Objective: In this study our aim was to determine the association between the histopathological such as grade and stage and clinical parameters age, tumor size, the number of tumor and reTUR and prognosis in pTa and pT1 bladder carcinomas which diagnosed in Medical Faculty of Abant Izzet Baysal University AIBU . Method: In total 119 consecutive and newly diagnosed patients with pTa and pT1 bladder tumors were analyzed retrospectively between 2008 and 2013. The histopathological and clinical data were obtained from Pathology and Urology Department of AIBU. Results: There were 109 men and 10 women in this study. The average follow-up period was 30.14 months 2.86-80.74 . There was statistically significant difference between recurrence and tumor size, grade, stage, the number of tumors, re-TUR and smoking; as well as between progression and grade, tumor size, the number of tumors and smoking in univariate analyses. The independent predictive markers were tumor size OR: 5.26, %95CI: 1.42-19.55 and smoking OR: 4.65,%95CI: 1.23-17.53 in recurrence and only grade OR: 5.32,%95CI 1.37-20.59 in progression according to multivariate analyses. The estimated recurrence time was respectively 14,8 months 11.41-18.31 and 7,6 months 5.76-9.49 in the size of tumor

Keywords:

Bladder cancer, grade, stage, recurrence, progression,

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