FLAVONOIDS FROM Cleome amblyocarpa

Cleome amblyocarpa'hm polar fraksiyonlarrndan yedi flavonoit bilegik elde edildi, alti tanesi daha once elde edilmis olan flavonoitler apigenin, kamferol3-glikozit, kersetin 3-glikozit-7-ramnozit, izoramnetin 3-glikozit-7-ramnozit, kamferol 3,7-diramnozit, kamferol7-ramnozit ve bir yeni kamferol tiirevi: kamferol7-metil eter 3-ramnozittir. Bu bilegiklerin yapllari spektral ve kimyasal metodlarla bulunmugtur. Cleome amblyocarpa'hm polar fraksiyonlarrndan yedi flavonoit bilegik elde edildi, alti tanesi daha once elde edilmis olan flavonoitler apigenin, kamferol3-glikozit, kersetin 3-glikozit-7-ramnozit, izoramnetin 3-glikozit-7-ramnozit, kamferol 3,7-diramnozit, kamferol7-ramnozit ve bir yeni kamferol tiirevi: kamferol7-metil eter 3-ramnozittir. Bu bilegiklerin yapllari spektral ve kimyasal metodlarla bulunmugtur.

Anahtar Kelimeler:

Cleorne arnblyocarp, Capparaceae, flavonoids

FLAVONOIDS FROM Cleome amblyocarpa

Seven flavonoids, six of them being known compounds, named apigenin, kaempferol 3-glucoside, quercetin 3-glucoside-7-rhamnoside, isorhamnetin 3- glucoside-7-rhamnoside, kaempferol 3, 7-dirhamnoside, kaempferol7-rhamnoside and the new derivative of kaempferol: kaempferol7-methyl ether 3-rhamnoside were obtained from the polar fractions of Cleome amblyocarpa. Their structures were determined by spectral and chemical methods.Cleome amblyocalpa and C. brachycarpa are used as folk medicine for the treatment of scabies, abdominal and rheumatic pains, fever and inflammation (1-5). In recent studies on the extracts of C. amblyocarpa (=C. afiicana) the subchronic effects (6), and antidiabetic activity in rats (7), as well as the anti-inflamatory, analgesic and antipyretic activities (8) were studied.

Keywords:

Cleorne arnblyocarpa, Capparaceae, flavonoids,

PDF

___

1. Ahmad, V.U., Alvi, K.A. and Khan, M.A., J. Nat. Prod., 49, 249 (1986).
2. Ahmad, V.U., Alvi, K.A., Plzyfoclzemisfry, 26,315 (1987).
3. Jente, R., Jakupovic, J. and Olatunji, G.A., Phytochemishy, 29,666 (1990).
4. Ahmad, V.U., Qazi, S., Bin Zia, N., Xu, C. and Clardy, J.,PIzyytocIzemistry, 29,670 (1990).
5. Tsichritzis, F., Abdel-Mogij, M. and Jakupovic, J., PI2ytoclzemistry, 33,424 (1993).
6. Abdel-Aziz, E.A., Farah, M.O., Harraz, F.M., Omar, A.A., Alex. J. Pharnz. Sci., 4, 147 (1990).
7. El-Mougy, S.A.F., Diab, A., Abdel-Aziz, S. and Omar, A.A., Alex, J. Pharm. Sci., 6 (I), 3 (1992).
8. Hmaz, F.M. and Ramadan, A., Zag. J. Pharm. Sci., (in press) (1994).
9. Mandaville, J.P. "Flora of Aestern Saudi Arabia" Kegan Paul International, London; National ,Comission for Wildlife Conservation and Development, Riyadh, p. 126 (1990).
10. Harraz, F.M., Ulubelen, A., Oksiiz, S. and Tan, N.,P/zytoclzenzishy, 39,175 (1995).
11. Carson, S.C. and Brown (Jr), K.S., Tetrahedrorz, 28, 315 (1972).
12. Omar, A.A., Planfa Medica, 59, (Supplement Issue) A 607 (1 993).
13. Mabry, T.J., Markham, K.K. and Thomas, M.B. "The Systematic Identification of Flavonoids", Springer-Verlag, New York, Heilderberg, Berlin (1970).