Suna Kucur, Halime Şencan, Kadriye Yüksel, İlay Gözükara, Ali Seven, Nadi Keskin, Ayşenur Değer

ENDOMETRİAL ÖRNEKLEME SONUÇLARIMIZ :744 OLGUNUN ANALİZİ (EVALUATION OF ENDOMETRIAL BIOPSY RESULTS IN OUR CLINIC; ANALYSIS OF 744 CASES)

Amaç: Kliniğimizde endometrial örnekleme yapılan olgularda, endikasyon ile histopatolojik sonuçlar arasındaki ilişkinin araştırılması. Materyal metod: Kliniğimize Ocak 2013- Ocak 2014 tarihleri arasında başvuran ve gebelik dışı herhangibir endikasyonla endometrial örnekleme yapılan 744 olgu retrospektif olarak değerlendirildi. Veriler hastanemiz arşivinden alındı. Endometrial örnekleme endikasyonları, menometroraji/menoraji, postmenapozal kanama, myom uteri ve servikal polip olarak gruplandırıldı. İstatistiksel analiz için SPSS 13 programı kullanıldı. Bulgular: Olguların yaşları 29 ile 79 arasında idi. Hastaların ortalama yaşları 43.6 +/- 8.3 idi. Endometrial örnekleme endikasyonları sırasıyla menometroraji/menoraji (%87), postmenopozal kanama (%9.5), servikal polip (%1.9), myom uteri (%1.6) idi. Histopatolojik sonuçlar ise sırayla proliferatif/sekretuar endometrium (%72.8), endometrial polip (%9.5), basit atipisiz hiperplazi (%7.9), atrofik endometrium (%3.5), endometrit (%3.2), yetersiz materyal (%0.9), endometrium kanseri (%0.8), basit atipili hiperplazi (%0.7), komplex atipili hiperplazi (%0.3), komplex atipisiz hiperplazi (%0.3) idi. Endometrium kanseri görülme oranı postmenapozal kanaması olan hasta grubunda %5.6 ile diğer gruplara oranla anlamlı derecede yüksek bulundu. En sık örnekleme endikasyonu menometroraji/menoraji saptanırken, bu olgularda endometrium kanseri sadece 2 (%0.3) olguda saptanmıştır. Myom uteri ve servikal polip nedeniyle yapılan endometrial örneklemelerde hiç endometrium kanseri görülmemiştir. Sonuç: En sık endometrial örnekleme endikasyonu menoraji/menometroraji iken endometrium kanseri açısından riskli grubun postmenopozal kanamalı olguların olduğu gösterilmiştir. Postmenapozal kanamalı hastalarda ciddi endometrial değerlendirme ve örnekleme yapılmalıyken myoma uteri nedeniyle histerektomi planan hastalarda operasyon öncesi endometrial örneklemenin gerekli bulunmamıştır. Fakat servikal polip olgularında endometriumunun değerlendirilmesinin gerektiği sonucuna varılmıştır.Anahtar kelimeler: endometrial örnekleme, anormal uterin kanama, endometrium kanseri ABSTRACTAims: to evaluate indications and histopathological diagnoses of endometrial samplings in our clinic.Materials-Methods: Seven hundred and fourty four subjects who required endometrial biopsy to be taken for any indication other than pregnancy between January 2013 and January 2014 were included in the study. Data collected retrospectively from Dumlupinar University Evliya Celebi Training and Research Hospital computer database and pathology clinic. Statistical analysis of data was performed using SPSS for Windows package programme. Results: Mean age of the subjects was 43.6 ± 8.3. Indications of endometrial sampling were menorrhagia/menometrorrhagia (87%), myoma uteri (1.6%), postmenopausal bleeding (9.5%), servical polyp (1.9%). Histopathologic diagnoses were as follows: secretory/proliferative endometrium in 72.8%, atrophic endometrium in 3.5%, simple atypical endometrial hyperplasia in 0.7%, simple typical endometrial hyperplasia in 7.9%, complex atypical endometrial hyperplasia in 0.3%, complex typical endometrial hyperplasia in 0.3%, atrophic endometrium in 3.5%, endometrium cancer in 0.8%, and endometrial polyp in 9.5%. Insufficient sampling material was reported in 0.9%. Endometrium cancer was detected in 5.6% of postmenopausal group. Conclusions: Our results emphasize that endometrial sampling is warranted especially in peri/postmenopausal women with abnormal uterine bleeding.Keywords: endometrial sampling, abnormal uterine bleeding, endometrial cancer

Anahtar Kelimeler:

endometrial örnekleme, anormal uterin kanama, endometrium kanseri

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Aims: To evaluate indications and histopathological diagnoses of endometrial samplings in our clinic.Materials-Methods: Seven hundred and fourty four subjects who required endometrial biopsy to be taken for any indication other than pregnancy between January 2013 and January 2014 were included in the study. Data collected retrospectively from Dumlupinar University Evliya Celebi Training and Research Hospital obstetrics and gynecology clinic database and pathology clinic. Statistical analysis of data was performed using SPSS for Windows 13 package programme.Results: Mean age of the subjects was 43.6 ± 8.3. Indications of endometrial sampling were menorrhagia/menometrorrhagia (87%), myoma uteri (1.6%), postmenopausal bleeding (9.5%), cervical polyp (1.9%). Histopathologic diagnoses were as follows: secretory/proliferative endometrium in 72.8%, atrophic endometrium in 3.5%, simple atypical endometrial hyperplasia in 0.7%, simple typical endometrial hyperplasia in 7.9%, complex atypical endometrial hyperplasia in 0.3%, complex typical endometrial hyperplasia in 0.3%, atrophic endometrium in 3.5%, endometrium cancer in 0.8%, and endometrial polyp in 9.5%. Insufficient sampling material was reported in 0.9%. Endometrium cancer was detected in 5.6% of postmenopausal group.Conclusion: The most common endometrial sampling indication was menorrhagia/menometrorrhagia, while endometrium cancer was detected most commonly in patients with postmenopausal bleeding. Our results emphasize that endometrial sampling is warranted especially in peri/postmenopausal women with abnormal uterine bleeding. Endometrial evaluation is needed in patients with cervical polyp.

Keywords:

endometrial sampling, abnormal uterine bleeding, endometrial cancerCİLT: 45 YIL: 2014 SAYI: 3,

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