Burçin ALTINBAŞ, Gökçen GÜVENÇ BAYRAM, Murat YALÇIN

Kronik Olarak İntraserebroventriküler Enjekte Edilen Histamin ve Antagonistlerinin Hipotalamo-Hipofizer-Aks Üzerindeki Etkisi

Merkezi sinir sistemi içerisinde nörotransmitter ve nöromodülatör etkiye sahip histamin, davranış durumunun, biyolojik ritmin, vücut ağırlığının, enerji metabolizmasının, termoregülasyonun, sıvı dengesinin, stresin ve üremenin düzenlenmesinde anahtar role sahiptir. Histaminin merkezi akut enjeksiyonlarının hipotalamo-hipofizer-gonadal (HPG) aks içerisinde etkili olduğunu ve histaminin merkezi H1 ve H2 reseptör-lerinin bu etkiye aracılık ettiğini gösterdik. Fakat çalışmalarda, histaminin ve histamin reseptör antagonistlerinin uzun süreli merkezi tedavilerinin HPG aks içerisindeki etkilerine dair açıklayıcı bir bilgi bulunmamaktadır. Çalışmada, kronik olarak intraserebroventriküler (i.s.v.) enjekte edilen histamin ve antagonistlerinin hipotalamo-hipofizer-gonadal (HPG) aksta rol oynayan, gonadotropin salgılatıcı hormonun (GnRH), folikül stimüle edici hormonun (FSH), lüteinleştirici hormonun (LH) ve testosteron hormonunun plazma seviyelerine etkileri araştırılmıştır. Çalışma Sprague-Dawley ırkı sıçanlarda gerçekleştirilmiştir. Histamin (100 nmol), histaminerjik H1 reseptör antagonisti klorfeni-ramin (100 nmol), histaminerjik H2 reseptör antagonisti ranitidin (100 nmol) veya histaminerjik H3/H4 reseptör antagonisti tiyoperamid (100 nmol) i.s.v. olarak 7 gün boyunca enjekte edilmiştir. Histamin ve antagonistlerinin kronik enjeksiyonu GnRH’nın plazma seviyelerinde anlamlı bir fark oluşturmamıştır. Kronik histamin veya klorfeniramin tedavisi sonucu plazma FSH seviyelerinde artış (p

Anahtar Kelimeler:

Histamin, Histamin antagonistleri, merkezi sinir sistemi, Hipotalamo-hipofizer-gonadal aks, İntraserebroventriküler

The Effect of Chronically Intracerebroventricular Injected Histamine and Its Antagonists on the Hypothalamic-Pituitary-Axis

Histamine, which has neurotransmitter and neuromodulatory effects in the CNS, has a key role in regulating behavioral state, biological rhythm, body weight, energy metabolism, thermoregulation, fluid balance, stress, and reproduction. We have shown that acute central injections of histamine are effective in the hypothalamic-pituitary-gonadal (HPG) axis and that histamine central H1/H2 receptors mediate this effect. However, there is no explanatory information about the effects of long-term central treatments of histamine and histamine receptor antagonists in the HPG axis in studies. In the study, the effects of chronically intracerebroventricular (i.c.v.) injected histamine and its antagonists on plasma levels of gonadotropin-releasing hormone (GnRH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone hormone, which play a role in the HPG axis, were investigated. Studies were performed in male Sprague–Dawley rats. Histamine (100 nmol), histaminergic H1 receptor antagonist chlorpheniramine (100 nmol), H2 receptor antagonist ranitidine (100 nmol), or H3/H4 receptor antagonist thioperamide (100 nmol) was injected i.c.v. for 7 days. Chronic injection of histamine and its antagonists did not make a significant difference in plasma levels of GnRH. Chronic histamine or chlorpheniramine treatment increased plasma FSH levels (p

Keywords:

Histamine, Histamine Antagonists, Central Nervous System, Hypothalamic-pituitary-gonadal axis, Intraserebroventricular,

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