Hematopoetik Kök Hücre Transplantasyonu Sonrası Yaşam: Hemşirenin Bakım Rolü

Hematopoetik kök hücre transplantansyonu (HKHT), yüksek riskli, ancak iyileştirici bir tedavidir. HKHT’de her aşama önemli olmakla birlikte tedavi sürecindeki geçişler bireyin sağ kalımında anahtar rol oynamaktadır. HKHT hastalarında taburculuk sonrası süreçte takip ve yönetim zordur. Birey, nakil merkezinden sonra çeşitli sorunlarla karşı karşıyadır. HKHT taburculuk sonrası süreçte bireylerin en sık karşılaştığı geç komplikasyonlar; graft versus host hastalığı (GVHD), enfeksiyöz komplikasyonlar, yorgunluk, sosyal uyumsuzluk (cinsellik, işe dönüş), psikolojik sıkıntı (depresyon, anksiyete) ve sekonder malign hastalıklardır. Birey maruziyetlerine dayalı olarak tarama ve önleyici yaşam boyu takibi gerekli olan bu özel grubun değerlendirilmesinde hemşirelik bakımı, bireye ve aileye rehberlik etmek ve tavsiyede bulunmak için en iyi konumdadır. Bireylerin uzun vadeli sağlığını korumak için hasta merkezli ve multidisipliner koordineli hemşirelik bakımı sağlanmalıdır. Bu derlemenin amacı, hematolojik maligniteleri olan yetişkinler için HKHT taburculuk sonrası yaşamla ilgili güncel literatürün kapsamlı genel görünümünü sağlamaktır ve taburculuk sonrası hemşirelik bakımını vurgulamaktır.

Anahtar Kelimeler:

Hematopoetik Kök Hücre Transpalantasyonu., Transplantasyon Sonrası Yaşam., Hemşire., Bakım.

Life after Hematopoietic Stem Cell Transplantation: Care Role of Nurses

Hematopoietic stem cell transplantation (HSCT) is a high risk but healing treatment. Although every stage is important in HSCT, transitions in the treatment process play a key role in survival. In HSCT patients, follow-up and management are difficult in the post discharge period. After from the transplant center, faces complications that may occur. The most common late complications encountered by HSCT in the post-discharge period are; graft versus host disease (GVHD), infectious complications, fatigue, social maladjustment (sexuality, return to work), psychological distress (depression, anxiety) and secondary malign diseases. Nursing care is in the best position to guide and advise the individual and the family in the assessment of this special group, which requires screening and preventive lifelong follow-up based on individual exposures. Patient-centered and multidisciplinary coordinated nursing care should be provided to protect the long-term health of individuals. The purpose of this review is for adults with hematological malignancies, HSCT related to life after discharge to provide a comprehensive overview of the current literatüre and emphasizing nursing care after discharge.

Keywords:

Hematopoietic Stem Cell Transplantation., Life After Transplantation., Nurse., Care.,

PDF

___

Referans1. Liang Y, Zhou M, Wang F, Wu Z. Exercise for physical fitness, fatigue and quality of life of patients undergoing hematopoietic stem cell transplantation: a meta-analysis of randomized controlled trials. Japanese Journal of Clinical Oncology. 2018;48(12):1046-57.
Referans2. Laudenslager ML, Simoneau TL, Mikulich Gilbertson SK et al. A randomized control trial of stress management for caregivers of stem cell transplant patients: effect on patient quality of life and caregiver distress. Psycho Oncology. 2019;28(8):1614-23.
Referans3. Crooks M, Seropian S, Bai M, McCorkle R. Monitoring patient distress and related problems before and after hematopoietic stem cell transplantation. Palliative & Supportive Care. 2014;12(1):53-61.
Referans4. Snowden JA, Saccardi R, Orchard K et al. Benchmarking of survival outcomes following haematopoietic stem cell transplantation: a review of existing processes and the introduction of an international system from the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE). Bone Marrow Transplantation. 2020;55(4):681-94.
Referans5. Cooke L, Grant M, Gemmill R. Patient-initiated discharge needs of allogeneic transplant patients. Clinical Journal of Oncology Nursing. 2012;16(4):142-9.
Referans6. Zheng LY, Yuan H, Zhou ZJ et al. The role of spirituality in patients undergoing hematopoietic stem cell transplantation: a systematic mixed studies review. Journal of General Internal Medicine. 2020;1-16.
Referans7. Thomson B, Gorospe G, Cooke L, Giesie P, Johnson S. Transitions of care: A hematopoietic stem cell transplantation nursing education project across the trajectory. Clinical Journal of Oncology Nursing. 2015;19(4):74-9.
Referans8. Mayer DK, Tighiouart H, Terrin N et al. A brief report of caregiver needs and resource utilization during pediatric hematopoietic stem cell transplantation. Journal of Pediatric Oncology Nursing. 2009;26(4):223-9.
Referans9. Leppla L, Mielke J, Kunze M et al. Clinicians and patients perspectives on follow-up care and eHealth support after allogeneic hematopoietic stem cell transplantation: a mixed-methods contextual analysis as part of the SMILe study. European Journal of Oncology Nursing. 2020;45:101723.
Referans10. Grant M, Cook L, Williams AC et al. Functional status and health-related quality of life among allogeneic transplant patients at hospital discharge: a comparison of sociodemographic, disease, and treatment characteristics. Supportive Care in Cancer. 2012;20(11):2697-704.
Referans11. Xie W, Zhang X, Wang J et al. Evaluation of quality of life and its influencing factors after transplantation of leukemia patients based on SF-36 score: a cohort study. Quality of Life Research. 2020;1-8.
Referans12. Kurosawa S, Mori A, Tsukagoshi M et al. Current status and needs of long-term follow-up clinics for hematopoietic cell transplantation survivors: results of a nationwide survey in Japan. Biology of Blood and Marrow Transplantation. 2020;26:949-55.
Referans13. de Azevedo IC, de Menezes RMP, de Medeiros SM et al. Hematopoietic stem cell transplantation based on the transdisciplinary care. International Archives of Medicine, 2016;9(28):1-6.
Referans14. Bevans M, El-Jawahri A, Tierney DK et al. National Institutes of Health hematopoietic cell transplantation late effects initiative: the patient-centered outcomes working group report. Biology of Blood and Marrow Transplantation. 2017;23(4):538-51.
Referans15. Kurosawa S, Tsukagoshi M, Munakata W et al. Cross-sectional patient survey on the need for a long-term follow-up program after autologous hematopoietic cell transplantation. Biology of Blood and Marrow Transplantation. 2016;22(3):189.
Referans16. Majhail NS, Rizzo JD, Lee SJ et al. Recommended screening and preventive practices for long-term survivors after hematopoietic cell transplantation. Hematology/Oncology and Stem Cell Therapy. 2012;5(1):1-30.
Referans17. Kenyon M, Murray J, Quinn B, Greenfield D, Trigoso E. Late effects and long-term follow-up. In: Kenyon M, Babic A (eds). The European blood and marrow transplantation textbook for nurses. London: Springer International Publishing. 2018. 271-300.
Referans18. Battiwalla M, Tichelli A, Majhail NS. Long-term survivorship after hematopoietic cell transplantation: roadmap for research and care. Biology of Blood and Marrow Transplantation. 2017;23(2):184-92.
Referans19. Heveran L, Andrewes T. Nursing measures to support the needs of haematological cancer survivors post-treatment: a literature review. British Journal of Nursing. 2020;29(3):18-24.
Referans20. Atsuta Y, Hirakawa A, Nakasone H et al. Late mortality and causes of death among long-term survivors after allogeneic stem cell transplantation. Biology of Blood and Marrow Transplantation. 2016;22(9):1702-9.
Referans21. Battiwalla M, Hashmi S, Majhail N et al. National Institutes of Health Hematopoietic Cell Transplantation late effects ınitiative: developing recommendations to improve survivorship and long-term outcomes. Biology of Blood and Marrow Transplantation. 2017;23(1):6-9.
Referans22. Majhail NS. Long-term complications after hematopoietic cell transplantation. Hematology/Oncology and Stem Cell Therapy. 2017;10(4):220-7.
Referans23. Mitchell SA, Leidy NK, Mooney KH et al. Determinants of functional performance in long-term survivors of allogeneic hematopoietic stem cell transplantation with chronic graft-versus-host disease (cGVHD). Bone Marrow Transplantation. 2010;45(4):762-9.
Referans24. Murray J, Stringer J, Hutt D. Graft Versus Host Disease (GvHD) In: Kenyon M, Babic A (eds). The European blood and marrow transplantation textbook for nurses. London: Springer International Publishing. 2018. 221-52.
Referans25. Neumann J. Nursing challenges caring for bone marrow transplantation patients with graft versus host disease. Hematology/Oncology and Stem Cell Therapy. 2017;10(4):192-4.
Referans26. Mitchell SA. Acute and Chronic Graft Versus Host Disease. In: Ezzone SA (eds). Hematopoietic Stem Cell Transplantation: A Manual for Nursing Care. 2 nd ed. Oncology Nursing Society. 2013. 103-54.
Referans27. Mattson MR. (2007). Graft-versus-host disease: review and nursing implications. Clinical Journal of Oncology Nursing. 2007;11(3):325-8.
Referans28. Woods AM. Daily routines and guidelines: driving, infection isolation, masks, food/diet, activities, exercise, pets, sun exposures, and others. In: Savani BN (eds). Blood and Marrow Transplantation Long-term Management: Prevention and Complications. John Wiley & Sons. 2013. 332-9.
Referans29. Peric Z, Botti S, Stringer J et al. Variability of nutritional practices in peritransplant period after allogeneic hematopoietic stem cell transplantation: a survey by the Complications and Quality of Life Working Party of the EBMT. Bone Marrow Transplantation. 2018;53(8):1030-7.
Referans30. Zatarain L, Hill LQ, Thomas DR, Goodman SA. Nutritional assessments and nutritional supplementation for long-term transplant survivors: multivitamins, vitamin D, calcium, antioxidants, and minerals. In: Savani BN (eds). Blood and Marrow Transplantation Long-term Management: Prevention and Complications. John Wiley & Sons. 2013. 323-31.
Referans31. van der Linden SJ, Harinck MEG, Speksnijder HT et al. Supportive Care. In: Kenyon M, Babic A (eds). The European blood and marrow transplantation textbook for nurses. London: Springer International Publishing. 2018. 197-220.
Referans32. Wallhult E, Quinn B. Early and acute complications and the principles of HSCT nursing care. In: Kenyon M, Babic A (eds). In The European blood and marrow transplantation textbook for nurses. Springer International Publishing. 2018. 163-95.
Referans33. Baer LK, Weinstein E, Daly B et al. Stem cell transplant and palliative care: joining forces to ımprove survivor quality of life. Biology of Blood and Marrow Transplantation. 2020;26(3):357.
Referans34. Park J, Wehrlen L, Mitchell SA, Yang L, Bevans MF. Fatigue predicts impaired social adjustment in survivors of allogeneic hematopoietic cell transplantation (HCT). Supportive Care in Cancer. 2019;27(4):1355-63.
Referans35. Baydoun M, Barton DL. (2018). Complementary therapies for fatigue after hematopoietic stem cell transplantation: an integrative review. Bone Marrow Transplantation. 2018;53(5):556-64.
Referans36. Pidala J, Anasetti C, Jim H. Health related quality of life following haematopoietic cell transplantation: patient education, evaluation and intervention. British Journal of Haematology. 2010;148(3):373-85.
Referans37. Niscola P, Efficace F, Abruzzese E. Sexual health in patients with hematological malignancies: a neglected issue. Supportive Care in Cancer. 2018;26(6):1699-701.
Referans38. Syrjala KL, Kurland BF, Abrams JR, Sanders JE, Heiman JR. Sexual function changes during the 5 years after high-dose treatment and hematopoietic cell transplantation for malignancy, with case-matched controls at 5 years. Blood, The Journal of the American Society of Hematology. 2008;111(3):989-96.
Referans39. Kirchhoff AC, Leisenring W, Syrjala KL. Prospective predictors of return to work in the 5 years after hematopoietic cell transplantation. Journal of Cancer Survivorship. 2010;4(1):33-44.
Referans40. Winterling J, Johansson E, Wennman-Larsen A et al. Occupational status among adult survivors following allo SCT. Bone Marrow Transplantation. 2014;49(6):836-42.
Referans41. Morrison EJ, Ehlers SL, Bronars CA et al. Employment status as an indicator of recovery and function one year after hematopoietic stem cell transplantation. Biology of Blood and Marrow Transplantation. 2016;22(9):1690-5.
Referans42. Braamse AM, van Meijel B, Visser O et al. Distress and quality of life after autologous stem cell transplantation: a randomized clinical trial to evaluate the outcome of a web-based stepped care intervention. BMC Cancer, 2010;10(1):361.
Referans43. Koll TT, Semin JN, Coburn RA et al. Returning to life activities after hematopoietic cell transplantation in older adults. Journal of Geriatric Oncology. 2020;11(2):304-10.
Referans44. Shah GL, Majhail N, Khera N, Giralt S. Value-based care in hematopoietic cell transplantation and cellular therapy: challenges and opportunities. Current Hematologic Malignancy Reports. 2018;13(2):125-134.
Referans45. Guffon N, Pettazzoni M, Pangaud N et al. Long term disease burden post-transplantation: three decades of observations in 25 Hurler patients successfully treated with hematopoietic stem cell transplantation (HSCT). Orphanet Journal of Rare Diseases. 2021;16(1):1-20.
Referans46. Majhail NS, Tao L, Bredeson C et al. Prevalence of hematopoietic cell transplant survivors in the United States. Biology of Blood and Marrow Transplantation. 2013;19(10):1498-501.
Referans47. Barban A, Coracin FL, Musqueira PT et al. (2014). Analysis of the feasibility of early hospital discharge after autologous hematopoietic stem cell transplantation and the implications to nursing care. Revista Brasileira de Hematologia e Hemoterapia. 2014;36(4):264-8.
Referans48. Brown M. Nursing care of patients undergoing allogeneic stem cell transplantation. Nursing Standard. 2010;25(11):47-56.
Referans49. McKenna DR, Sullivan MR, Hill JM et al. Hospital readmission following transplantation: identifying risk factors and designing preventive measures. The Journal of Community and Supportive Oncology. 2015;13(9):316-22.
Referans50. Hashmi SK, Bredeson C, Duarte RF et al. National institutes of health blood and marrow transplant late effects initiative: the healthcare delivery working group report. Biology of Blood and Marrow Transplantation. 2017;23(5):717-25.
Referans51. Shaw BE, Hahn T, Martin PJ et al. National institutes of health hematopoietic cell transplantation late effects initiative: the research methodology and study design working group report. Biology of Blood and Marrow Transplantation. 2017;23(1):10-23.
Referans52. Fauer AJ, Hoodin F, Lalonde L et al. Impact of a health information technology tool addressing information needs of caregivers of adult and pediatric hematopoietic stem cell transplantation patients. Supportive Care in Cancer. 2019;27(6):2103-12.
Referans53. Bryant AL, Coffman E, Phillips B et al. Pilot randomized trial of an electronic symptom monitoring and reporting intervention for hospitalized adults undergoing hematopoietic stem cell transplantation. Supportive Care in Cancer. 2020;28(3):1223-31.