Ayşe ECEVİT, Deniz ANUK İNCE, Özden TURAN

Maternal D Vitamini Eksikliğine Bağlı Geç Neonatal Hipokalsemi

Maternal D vitamini eksikliği dünyada yaygın ve önemli bir sağlık problemidir. Neonatal D vitamini eksikliği ve neonatal hipokalsemi için de major risk faktörlerinden birisidir. Yenidoğanın vitamin D konsantrasyonu annenin D vitamini durumu ile yakından ilişkilidir. Burada, maternal D vitamini eksikliği ile birlikte geç neonatal hipokalsemisi olan iki yenidoğan olgusu sunuldu.

Anahtar Kelimeler:

Maternal D vitamini eksikliği, Yenidoğan

Deficiency Neonatal Late-Onset Hypocalcemia due to Maternal Vitamin D

Maternal D vitamin deficiency is a common and important health problem in the world. It is one of the major risk factors for neonatal vitamin D deficiency and neonatal hypocalcemia. The neonatal vitamin D concentration depends on the maternal vitamin D status. We report two neonates with late-onset hypocalcemia and maternal vitamin D deficiency.

Keywords:

Maternal vitamin D deficiency, Newborn,

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Mutlu GY, Özsu E, Oruç M, Çizmecioğlu F, Hatun Ş. Maternal D vitamini eksikliğine bağlı hipokalsemik nöbet nasıl önlenebilir? Çocuk Sağlığı ve Hastalıkları Dergisi 2011;54:79-82.
Rigo J, Mohamed WM, Curtis MDE. Disorders of calcium/ phosphor/magnesium metabolism. In: Martin R, Fanaroff A, Walsh M (eds). Fanaroff and Martins Neonatal-Perinatal Medicine: Disease of the Fetus and Infant, Vol 2, 9th ed. Philadelphia: Elsevier Mosby, 2011:1523-56.
Burris HH, Rifas-Shiman SL, Camargo CA Jr, Litonjua AA, Huh SY, Rich-Edwards JW, et al. Plasma 25-hydroxyvitamin D during pregnancy and small-for-gestational age in black and white infants. Ann Epidemiol 2012;22:581-6.
Pérez-López FR, Pasupuleti V, Mezones-Holguin E, Benites- Zapata VA, Thota P, Deshpande A, et al. Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: A systematic review and meta-analysis of randomized controlled trials. Fertil Steril 2015;103:1278-88.
Do HJ, Park JS, Seo JH, Lee ES, Park CH, Woo HO, et al. Neonatal late-onset hypocalcemia: Is there any relationship with maternal hypovitaminosis D? Pediatr Gastroenterol Hepatol Nutr 2014;17:47-51.
Hollis BW, Wagner CL. Assessment of dietary vitamin D requirements during pregnancy and lactation. Am J Clin Nutr 2004;79:717-26.
Lamberg-Allardt C, Larjosto M, Schultz E. 25-Hydroxyvitamin D concentrations in maternal and cord blood at delivery and in maternal blood during lactation in Finland. Hum Nutr Clin Nutr 1984;38:261-8.
Rodda CP, Benson JE, Vincent AJ, Whitehead CL, Polykov A, Vollenhoven B. Maternal vitamin D supplementation during pregnancy prevents vitamin D deficiency in the newborn: An open-label randomized controlled trial. Clin Endocrinol (Oxf) 2015;83:363-8.
Yu CK, Sykes L, Sethi M, Teoh TG, Robinson S. Vitamin D deficiency and supplementation during pregnancy. Clin Endocrinol (Oxf) 2009;70:685-90.
Brooke OG, Brown IR, Bone CD, Carter ND, Cleeve HJ, Maxwell JD, et al. Vitamin D supplements in pregnant Asian women: Effects on calcium status and fetal growth. Br Med J 1980;280:751-4.
Halicioglu O, Aksit S, Koc F, Akman SA, Albudak E, Yaprak I, et al. Vitamin D deficiency in pregnant women and their neonates in spring time in western Turkey. Paediatr Perinat Epidemiol 2012;26:53-60.
Johnson DD, Wagner CL, Hulsey TC, McNeil RB, Ebeling M, Hollis BW. Vitamin D deficiency and insufficiency is common during pregnancy. Am J Perinatol 2011;28:7-12.
De-Regil LM, Palacios C, Ansary A, Kulier R, Peña-Rosas JP. Vitamin D supplementation for women during pregnancy. Cochrane Database Syst Rev 2012;15:2.
Godang K, Frİslie KF, Henriksen T, Qvigstad E, Bollerslev J. Seasonal variation in maternal and umbilical cord 25(OH) vitamin D and their associations with neonatal adiposity. Eur J Endocrinol 2014;13:609-17.
TC Sağlık Bakanlığı. Bebeklerde D vitamini Yetersizliğinin Önlenmesi ve Kemik Sağlığının Geliştirilmesi Programı. Erişim tarihi: 1 Ocak 2005. Available from: http.//www.saglik.gov.tr/TR/belge/1-11576/ bebeklerde-d-vitamini-yetersizliginin-onlenmesi-ve-kemik-htlm.
TC Sağlık Bakanlığı. Gebelere D Vitamini Destek Programı. Erişim tarihi: 1 Ocak 2011. Available from: http://www.saglik.gov.tr/TR/ belge/1-12656/gebelere-d-vitamini-destek-programi.
ACOG Committee on Obstetric Practice. ACOG Committee Opinion No:495: Vitamin D: Screening and supplementation during pregnancy. Obstet Gynecol 2011;118:197-8.