Sezer ACAR, Erdem ERKOYUN, Hale TUHAN, Ece BÖBER, Korcan DEMİR, Ayhan ABACI

Doğumsal Hipotiroidi ile Ebeveyn Yaşı İlişkisi

p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 9.0px Helvetica} Amaç: Çalışmamızda, tiroid disgenezisi ile ebeveyn yaşı arasındaki ilişkiyi değerlendirmeyi amaçladık. Gereç ve Yöntemler: Kliniğimizde yaşları 0-17.9 arasında değişen, tiroid disgenezisi tanısı ile takip edilen 105 hastanın verileri incelendi. Hastaların ve ebeveynlerinin yaşı, cinsiyeti, anne-baba arasındaki akrabalık durumu, ailede doğumsal hipotiroidi öyküsü, klinik ve laboratuvar bulguları kaydedildi. Hasta gruplarındaki doğum tarihleri dikkate alınarak ve doğum tarihleri eşleştirilerek her bir hastaya altı sağlıklı çocuk olacak şekilde kontrol grubu oluşturuldu. Bulgular: Çalışmaya 105 tiroid disgenezisi tanılı olgu (56 kız, %53.3) ve 630 kontrol dahil edildi. Elli olguda (%47.6) hipoplazi, 26 olguda (%24.8) ektopi, 20 olguda (%19.0) aplazi, 9 olguda (%8.6) hemiagenezi saptandı. Tiroid disgenezili olguların anne yaşları ortalaması 27.87 ± 5.36 yıldı, kontrol grubuna göre daha yüksek saptandı (p<0,05). Anne yaş grupları yüzdeleri karşılaştırıldığında 28-31 yaş grubunda ve 32 ve üzeri yaş grubunda tiroid disgenezili bebek sahibi olma riski yüksek saptandı (p<0.05). Sonuç: Çalışmamız, tiroid disgenezisi tanılı olgularda anne yaşının sağlıklı kontrollere göre daha ileri olduğunu göstermiştir

Anahtar Kelimeler:

Doğumsal hipotiroidi, Tiroid disgenezisi

The Relation Between Congenital Hypothyroidism and Parental Age

Objective: In this study, we aimed to evaluate the relationship between thyroid dysgenesis and parental age.Material and Methods: A total of 105 patients with thyroid dysgenesis who were between 0-17.9 years of agewere studied. The age of the patients and their parents, gender, parental consanguinity, family history of congenitalhypothyroidism, clinical and laboratory findings were recorded. Control group consist of six healthy children for eachpatient, considering their birth dates.Results: A total of 105 patients (56 females, 53.3%) with thyroid dysgenesis and 630 controls were included in thestudy. Hypoplasia was detected in 50 cases (46.6%), ectopia in 26 cases (24.8%), aplasia in 20 cases (19.0%) andhemiagenesis in 9 cases (8.6%). The mean maternal age of the patients with thyroid dysgenesis was 27.87±5.36 years,which is significantly higher than the control group (p<0.05). There was an increased risk of having a baby with thyroiddysgenesis in the 28-31 years and > 32 years age groups (p<0.05).Conclusion: Our study showed that maternal age was higher in the patients with thyroid dysgenesis than in the control p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 9.0px Helvetica} group.

Keywords:

Congenital hypothyroidism, Thyroid dysgenesis,

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