Mustafa Kemal SARIBAY, Ayşe Merve KÖSE, Bülent ÖZSOY, Umaır AHSAN, Ece Koldaş ÜRER, Serkan İrfan KÖSE, Gökhan DOĞRUER

The effects of supplemental niacin and methionine on serum glucose, betahydroxybutyric acid, and non-esterified fatty acid levels during late gestation and early postpartum period in Damascus dairy goat

The objective of this study was to assess the changes in serum glucose, beta-hydroxybutyric acid ß-HBA , and nonesterified fatty acid NEFA levels in Damascus dairy goats fed niacin Nia and methionine Met during late gestation and early postpartum period. A total of 75 dairy goats at 105th day of gestation were divided into 3 groups as control no supplementation , Nia 20 g/kg Nia , and Met 2.5 g/kg Met groups. The dietary treatments continued until parturition. Dairy goats fed dietary Nia had greater serum glucose levels on day 125 of gestation compared to the other dietary treatments P

Keywords:

Glucose, goat, methionine, NEFA, niacin, ß-HBA,

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1. Conway M, Blackshaw J, Daniel R. The effects of agonistic behaviour and nutritional stress on both the success of pregnancy and various plasma constituents in Angora goats. Applied Animal Behaviour Science 1996; 48 (1-2): 1-13. doi: 10.1016/0168-1591(95)01024-6
2. Institut National de la Recherche Agronomique (INRA). Alimentation des Bovins, Ovins et Caprins. Paris, France: INRA; 1988.
3. Mayer E, Liebich HG, Arbitman R, Hagemeister H, Dirksen G. Nutritionally-induced changes in the rumenal papillae and in their capacity to absorb short chain fatty acids in high producing dairy cows. In: Proceedings of 14th World Congress on Diseases of Cattle; Dublin, Ireland; 1986. pp. 806-817.
4. Firat A, Ozpinar A. Metabolic profile of pre-pregnancy, pregnancy and early lactation in multiple lambing Sakiz ewes. Annals of Nutrition Metabolism 2002; 46 (2): 57. doi: 10.1159/000070036
5. Moghaddam G, Hassanpour A. Comparison of blood serum glucose, beta hydroxybutyric acid, blood urea nitrogen and calcium concentrations in pregnant and lambed ewes. Journal of Animal and Veterinary Advances 2008; 7 (3): 308-311. doi: javaa.2008.308.311
6. Schlumbohm C, Harmeyer J. Twin-pregnancy increases susceptibility of ewes to hypoglycaemic stress and pregnancy toxaemia. Research in Veterinary Science 2008; 84 (2): 286-299. doi: 10.1016/j.rvsc.2007.05.001
7. Van Saun RJ. Pregnancy toxemia in a flock of sheep. Journal of the American Veterinary Medical Association 2000; 217 (10): 1536-1539. doi: 10.1016/j.rvsc.2007.05.001
8. Brozos C, Mavrogianni VS, Fthenakis GC. Treatment and control of peri-parturient metabolic diseases: pregnancy toxemia, hypocalcemia, hypomagnesemia. Veterinary Clinics: Food Animal Practice 2011; 27 (1): 105-113. doi: 10.1016/j. cvfa.2010.10.004
9. Bani Ismail ZA, Al‐Majali AM, Amireh F, Al‐Rawashdeh OF. Metabolic profiles in goat does in late pregnancy with and without subclinical pregnancy toxemia. Veterinary Clinical Pathology 2008; 37 (4): 434-437. doi: 10.1111/j.1939- 165X.2008.00076.x
10. Lima MS, Pascoal RA, Stilwell GT. Glycaemia as a sign of the viability of the foetuses in the last days of gestation in dairy goats with pregnancy toxaemia. Irish Veterinary Journal 2012; 65 (1): 1. doi: 10.1186/2046-0481-65-1
11. Danieli PP, Lacetera N, Bernabucci U, Ronchi B. Conventional and homeopathic treatments in late pregnant goats: effects on metabolic status and immune response. Italian Journal of Animal Science 2009; 8 (Suppl. 2): 613-615. doi: 10.4081/ijas.2009.s2.613
12. Rook JS. Pregnancy toxemia of ewes, does, and beef cows. Veterinary Clinics of North America: Food Animal Practice 2000; 16 (2): 293-317. doi: 10.1016/S0749-0720(15)30107-9
13. Kaçar C, Zonturlu AK, Karapehlivan M, Arı UÇ, Öğün M et al. The effects of L-carnitine administration on energy metabolism in pregnant Halep (Damascus) goats. Turkish Journal of Veterinary and Animal Sciences 2010; 34 (2): 163-171. doi: 10.3906/vet-0805-11
14. Menzies PI. Pregnancy Toxemia in Ewes and Does: Hepatic Lipidosis: Merck Veterinary Manual. USA: Merial; 2011.
15. Hristovska T, Cincović M, Stojanović D, Belić B, Kovačević Z et al. Influence of niacin supplementation on the metabolic parameters and lipolysis in dairy cows during early lactation. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 2017; 23 (5): 773-778. doi: 10.9775/kvfd.2017.17743
16. Sun F, Cao Y, Cai C, Li S, Yu C et al. Regulation of nutritional metabolism in transition dairy cows: Energy homeostasis and health in response to post-ruminal choline and methionine. PLoS One 2016; 11 (8): 1-27. doi: 10.1371/journal. pone.0160659
17. Harmeyer J, Schlumbohm C. Pregnancy impairs ketone body disposal in late gestating ewes: Implications for onset of pregnancy toxaemia. Research in Veterinary Science 2006; 81 (2): 254-264. doi: 10.1016/j.rvsc.2005.10.010
18. Bell AW, Kennaugh J, Battaglia FC, Makowski EL, Meschia G. Metabolic and circulatory studies of fetal lamb at midgestation. American Journal of Physiology-Endocrinology and Metabolism 1986; 250 (5): E538-E544. doi: 10.1152/ ajpendo.1986.250.5.E538
19. Lindsay DB, Oddy VH. Pregnancy toxaemia in sheep–a review. In: Recent Advances in Animal Nutrition in Australia. Proceedings of a Symposium at the University of New England; 1985. pp. 24-27.
20. Marutsova VJ, Binev RG. Changes in blood enzyme activities and some liver parameters in goats with subclinical ketosis. Bulgarian Journal of Veterinary Medicine 2018; Online First ISSN: 1311-1477. doi: 10.15547/bjvm.2175
21. Duehlmeier R, Fluegge I, Schwert B, Parvizi N, Ganter M. Metabolic adaptations to pregnancy and lactation in German Blackheaded Mutton and Finn sheep ewes with different susceptibilities to pregnancy toxaemia. Small Ruminant Research 2011; 96 (2-3): 178-184. doi: 10.1016/j. smallrumres.2010.12.002
22. Sadjadian R, Seifi HA, Mohri M, Naserian AA, Farzaneh N. Variations of energy biochemical metabolites in periparturient dairy Saanen goats. Comparative Clinical Pathology 2013; 22 (3): 449-456. doi: 10.1007/s00580-012-1431-8
23. Harmeyer J, Kollenkirchen U. Thiamin and niacin in ruminant nutrition. Nutrition Research Reviews 1989; 2 (1): 201-225. doi: 10.1079/NRR19890015
24. Niehoff ID, Hüther L, Lebzien P. Niacin for dairy cattle: a review. British Journal of Nutrition 2008; 101 (1): 5-19. doi: 10.1017/S0007114508043377
25. Campbell J, Murphy M, Christensen R, Overton T. Kinetics of niacin supplements in lactating dairy cows. Journal of Dairy Science 1994; 77 (2): 566-575. doi: 10.3168/jds.S0022- 0302(94)76985-X
26. Jaster EH, Ward NE. Supplemental nicotinic acid or nicotinamide for lactating dairy cows. Journal of Dairy Science 1990; 73 (10): 2880-2887. doi: 10.3168/jds.S0022-0302(90)78975-8
27. Dufva G, Bartley E, Dayton A, Riddell D. Effect of niacin supplementation on milk production and ketosis of dairy cattle. Journal of Dairy Science 1983; 66 (11): 2329-2336. doi: 10.3168/jds.S0022-0302(83)82089-X
28. Polan CE, Cummins K, Sniffen C, Muscato T, Vicini J et al. Responses of dairy cows to supplemental rumen-protected forms of methionine and lysine. Journal of Dairy Science 1991; 74 (9): 2997-3013. doi: 10.3168/jds.S0022-0302(91)78486-5
29. Grummer RR. Etiology of lipid-related metabolic disorders in periparturient dairy cows. Journal of Dairy Science 1993; 76 (12): 3882-3896. doi: 10.3168/jds.S0022-0302(93)77729-2
30. Herdt TH. Ruminant adaptation to negative energy balance: Influences on the etiology of ketosis and fatty liver. Veterinary Clinics of North America: Food Animal Practice 2000; 16 (2): 215-230. doi: 10.1016/S0749-0720(15)30102-X
31. Waterman R, Schultz L. Methionine hydroxy analog treatment of bovine ketosis: effects on circulating metabolites and interrelationships. Journal of Dairy Science 1972; 55 (10): 1513-1516. doi: 10.3168/jds.S0022-0302(72)85707-2
32. Schlumbohm C, Harmeyer J. Hyperketonemia impairs glucose metabolism in pregnant and nonpregnant ewes. Journal of Dairy Science 2004; 87 (2): 350-358. doi: 10.3168/jds.S0022- 0302(04)73174-4
33. Moallem U, Rozov A, Gootwine E, Honig H. Plasma concentrations of key metabolites and insulin in late-pregnant ewes carrying 1 to 5 fetuses. Journal of Animal Science 2012; 90 (1): 318-324. doi: 10.2527/jas.2011-3905
34. Heitmann R, Fernandez J. Autoregulation of alimentary and hepatic ketogenesis in sheep. Journal of Dairy Science 1986; 69 (5): 1270-1281. doi: 10.3168/jds.S0022-0302(86)80533-1