Kürşat ÖZER, Kemal ALTUNATMAZ, Ahmet GÜLÇUBUK

Hybertrophic osteodystrophy in the dog: 18 cases

Yaşları 2,5 ile 8 ay arasında değişen 16 erkek 2 dişi yavru köpekte hipertrofik osteodistrofi tanısı konuldu. Hayvanların hepsinde; ağrılı ve zahmetli yürüyüş, antebrachium ve tibia'larının metafiz bölgelerinde ağrılı şişkinlikler, beden ısısında artış, zayıflık ve diare gibi semptomlarla karşılaşıldı. Hastalıktan etkilenmiş bölgelerin radyolojik görüntülerinde ekstraperiostal kemik üremelerinin varlığı tespit edildi. Kronik olgularda, kemiklerin diafizinden başlayan proksimal ve distal metafize kadar uzanan kemik üremeleri gözlendi, iki köpek, parenteral kortikosteroid, ağrı kesici, C vitamini ve antibiyotik uygulanması suretiyle tedaviye alındı. Bu köpekler uzun tedavi süresince iyileşme gösterdiler, ancak tedavinin kesilmesinden hemen sonra öldüler. Onbeş köpek sorunsuz iyileşti. Bu 15 köpek sadece diyet düzenlenmesi ile sağaltıldılar. Diğer bir olgu herhangi bir sağaltım uygulanmadan hasta sahibinin isteği üzerine ötenazi edildi. Nekropsileri yapılan iki köpeğin histopatolojik incelemesinde epifız plağı normal görünümdeydi. Ancak, hemen altında başlayan primer ve sekunder spongioz kemiğin, metafizyal kemik alanına kadar nekroze olup, yer yer rezorbe olduğu gözlendi. Periostal bölgede, ekstraperiostal kemik üremeleri ve yine bu alanlarda osteoklastik aktiviteye bağlı kemik yıkımlanmaları, bağ doku artışı ve nötrofil lökosit infiltrasyonu izlendi.

Köpeklerde hipertrofik osteodistrofi: 18 olgu

Hypertrophic osteodystrophy was diagnosed in 16 male and 2 female puppies aged between 2.5 and 8 months. All animals had stiff and stilted gait, painful swellings in the metaphyseal areas of the antebrachium and tibia, pyrexia, weakness and diarrhoea as common symptoms. Radiological examination of the affected areas showed extraperiosteal bone proliferations. With chronicity, the new bone formation spanned the entire diaphysis from the distal to the proximal metaphysis. Two dogs were treated with parenteral administration of analgesics, corticosteroids, vitamin C, and antibiotics in addition to dietary management. These 2 puppies, which had shown a clinical improvement during the long therapy period, died immediately after the cessation of drug administration. Fifteen animals recovered completely. These 15 puppies underwent dietary management only. The other dog was euthanised without any treatment at the owner's request. In the histopathologic examination of 2 dogs, in which a necropsy was performed, epiphyseal plates were structurally normal. However, primary and secondary spongiosa immediately below were observed to have been destroyed, extending up to the metaphyseal zone, and resorption had occurred in some areas. In the periostal zone, extraperiostal ossification, foci of bone destruction due to the osteoclastic activity, development of fibrous tissue, and infiltration by numerous neutrophils were observed.

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