İsmail ÇELİK, Vedat TÜRKOĞLU, Esref YEĞİN

120135

Effects of Propylthiouracil-Induced Hypothyroidism on Plasma Lipid Table in Rabbits

Hypothyroidism is commonly associated with hyperlipidemia. The aim of this study was to investigate the effect of Propylthiouracil-induced hypothyroidism on the plasma lipid profile in rabbits. This investigation was performed on male, white New Zealand ( Oryctolagus cuniculus huxley) rabbits. Twenty rabbits were used; each of the two groups (hypothyroidism and control) consisted of ten animals. Hypothyroidism was induced by oral administration of Propylthiouracil 50 mg.kg -1 for three weeks. The mean values of Triiodothyronine (T 3 ), thyroxine (T 4 ), free T 3 (FT 3 ) and free T 4 (FT 4 ) were 121.7±32.7 ng/d1, 1.81±0.60 µg/dl, 2.36±9b92 ng/dl and 0.43±0.22 p mol/dl in the control group, and 88.4±19.2 ng/dl, 1.15±0.37 µg/dl, 1.48±0.44 ng/dl and 0.18±0.11p mol/dl in the hypothyroidism group, respectively (p
Anahtar Kelimeler:

Hypothyroidism, lipid, rabbit.

Effects of Propylthiouracil-Induced Hypothyroidism on Plasma Lipid Table in Rabbits

Hypothyroidism is commonly associated with hyperlipidemia. The aim of this study was to investigate the effect of Propylthiouracil-induced hypothyroidism on the plasma lipid profile in rabbits. This investigation was performed on male, white New Zealand ( Oryctolagus cuniculus huxley) rabbits. Twenty rabbits were used; each of the two groups (hypothyroidism and control) consisted of ten animals. Hypothyroidism was induced by oral administration of Propylthiouracil 50 mg.kg -1 for three weeks. The mean values of Triiodothyronine (T 3 ), thyroxine (T 4 ), free T 3 (FT 3 ) and free T 4 (FT 4 ) were 121.7±32.7 ng/d1, 1.81±0.60 µg/dl, 2.36±9b92 ng/dl and 0.43±0.22 p mol/dl in the control group, and 88.4±19.2 ng/dl, 1.15±0.37 µg/dl, 1.48±0.44 ng/dl and 0.18±0.11p mol/dl in the hypothyroidism group, respectively (p
Keywords:

Hypothyroidism, lipid, rabbit.,

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Turkish Journal of Veterinary and Animal Sciences-Cover
  • ISSN: 1300-0128
  • Yayın Aralığı: 6
  • Yayıncı: TÜBİTAK
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