SAKDICHOD KIMSAKULVECH, PEERASAK SUTTIYOTIN, ANUCHAI PINYOPUMMIN

Dose-dependent effects of tamsulosin on the ejaculation and semen quality in bucks

The objective of this study was to investigate the effect of tamsulosin (TAM) dosages on ejaculation and semen quality. Two sets of Latin square experiment design were applied to 6 bucks receiving normal saline (CON), TAM 134.8 nM/kg (LTAM), or 269.7 (HTAM) nM/kg at 1-week intervals. Semen collection, libido, and ejaculatory scoring were undertaken at 3, 6, 9, 12, and 24 h after injection. Heart rate and body temperature were measured before administration and at 30 min, and before semen collection. The results showed that libido score and heart rate were not affected by treatments. Ejaculatory suppression was observed in both TAM groups. The percentage of ejaculatory suppression was 91.7% by 3 h for both TAM dosages and gradually diminished. Ejaculatory recovery in all bucks was observed by 12 h. Ejaculatory suppression remained unchanged between LTAM and HTAM, but HTAM caused more anejaculation by 6 h (P < 0.05). Some semen parameters of both TAM groups were significantly different from the CON group from 6 to 12 h; however, the values returned to being similar by 24 h. Both TAM dosages had temporary effects on ejaculatory suppression and semen quality, and the effective period was dose-dependent.

Anahtar Kelimeler:

Alpha adrenoceptor antagonist, tamsulosin, buck, semen, ejaculation

Dose-dependent effects of tamsulosin on the ejaculation and semen quality in bucks

Keywords:

Alpha adrenoceptor antagonist, tamsulosin, buck, semen, ejaculation,

PDF

___

Hellstrom WJG, Sikka SC. Effects of acute treatment with tamsulosin versus alfuzosin on ejaculatory function in normal volunteers. J Urol 2006; 176: 1529–1533.
Hisasue S, Furuya R, Itoh N, Kobayashi K, Furuya S, Tsukamoto T. Ejaculatory disorder caused by alpha-1 adrenoceptor antagonists is not retrograde ejaculation but a loss of seminal emission. Int J Urol 2006; 13: 1311–1316.
Kimsakulvech S, Suttiyotin P, Pinyopummin A. Effects of alpha1-adrenoceptor antagonist (tamsulosin) on incident of ejaculation and semen quality in the goat. Andrologia 2015; 47: 354–359.
Foglar R, Shibata K, Horie K, Hirasawa A, Tsujimoto G. Use of recombinant alpha 1-adrenoceptors to characterize subtype selectivity of drugs for the treatment of prostatic hypertrophy. Eur J Pharmacol 1995; 288: 201–207.
Taguchi K, Saitoh M, Sato S, Asano M, Michel MC. Effects of tamsulosin metabolites at alpha-1 adrenoceptor subtypes. J Pharmacol Exp Ther 1997; 280: 1–5.
Yamada S, Suzuki M, Tanaka C, Mori R, Kimura R, Inagaki O, Honda K, Asano M, Takenaka T, Kawabe K. Comparative study on alpha1 adrenoceptor antagonist binding in human prostate and aorta. Clin Exp Pharmacol Physiol 1994; 21: 405–411.
Kobayashi S, Tomiyama Y, Tatemichi S, Hoyano Y, Kobayashi M, Yamazaki Y. Effects of silodosin and tamsulosin on the urethra and cardiovascular system in young and old dogs with benign prostatic hyperplasia. Eur J Pharmacol 2009; 613: 135–140.
Giuliano F, Bernabe J, Droupy S, Alexandre L, Allard J. A comparison of the effects of tamsulosin and alfuzosin on neurally evoked increases in bladder neck and seminal vesicle pressure in rats. BJU Int 2004; 93: 605–608.
Giuliano FA, Clement P, Denys P, Alexandre L, Bernabe J. Comparison between tamsulosin and alfuzosin on the expulsion phase of ejaculation in rats. BJU Int 2006; 98: 876–879.
Smith ER, Lee RL, Schnur SL, Davidson JM. Alpha2 adrenoceptor antagonists and male sexual behavior: I. Mating behavior. Physiol Behav 1987; 41: 7–14.
Yonezawa A, Ando R, Watanabe C, Furuta S, Kutsuwa M, Sakurada S, Kimura Y. Alpha2 adrenoceptor antagonists: effects on ejaculation, penile erection and pelvic thrusting behavior in dogs. Pharmacol Biochem Behav 2001; 70: 141–147.
Ohtake A, Sato S, Saitoh C, Yuyama H, Sasamata M, Miyata K. Effects of tamsulosin on hypogastric nerve stimulation-induced intraurethral pressure elevation in male and female dogs under anesthesia. Eur J Pharmacol 2004; 497: 327–334.
Frydrychova S, Opletal L, Macakova K, Lustykova A, Rozkot M, Lipensky J. Effects of herbal preparation on libido and semen quality in boars. Reprod Domest Anim 2011; 46: 573–578.
Revell SG, Mrode RA. An osmotic resistance test for bovine semen. Anim Reprod Sci 1994; 36: 77–86.
Yanai-Inamura H, Ohtake A, Noguchi Y, Hatanaka T, Suzuki M, Ueshima K, Sato S, Sasamata M. Effects of alpha1 adrenoceptor antagonists on phenylephrine-induced salivary secretion and intraurethral pressure elevation in anesthetized rats. Eur J Pharmacol 2012; 679: 127–131.
Andersson KE, Wyllie MG. Ejaculatory dysfunction: why all alpha-blockers are not equal. BJU Int 2003; 92: 876–877.
Ohtake A, Ukai M, Saitoh C, Sonoda R, Noguchi Y, Okutsu H, Yuyama H, Sato S, Sasamata M, Miyata K. Effect of tamsulosin on spontaneous bladder contraction in conscious rats with bladder outlet obstruction: comparison with effect on intraurethral pressure. Eur J Pharmacol 2006; 545: 185–191.
Kaya A, Aksoy M, Tekeli T. Influence of ejaculation frequency on sperm characteristics, ionic composition and enzymatic activity of seminal plasma in rams. Small Rumin Res 2002; 44: 153–158.
Ritar AJ, Mendoza G, Salamon S, White IG. Frequent semen collection and sperm reserves of the male Angora goat (Capra hircus). J Reprod Fertil 1992; 95: 97–102.
Joni LF. Semen collection and evaluation. Clin Tech Small Anim Pract 2002; 17: 104–107.