Irena DUMALAKIENE, Irena JONAUSKIENE, Laimis AKRAMAS, Laima LEONAVICIENE, Ruta BRADUNAITE, Audrius VASILIAUSKAS, Danguole ZABULYTE, Teresa NORMANTIENE, Dalia VAITKIENE

Antiinflammatory effect of herbal preparations on adjuvant arthritis in rats

The present study aimed to investigate the antiinflammatory effects of 2 herbal extracts (CDS and CDSM) in rats withexperimental adjuvant arthritis (AA). Joint swelling, development of polyarthritis, blood indices, pro/antioxidant activity, andproinflammatory cytokine IL-17 in blood serum, as well as the liver and paw histopathology and histochemistry, were assessed. Oralinjections of extracts showed an antiinflammatory effect analogous to that of diclofenac (DF), improved blood indices and suppressedlevel of IL-17, significantly diminished joint swelling, and histological changes in the joints. Increase in CAT activity and AOA andreduction in lipid peroxidation was noted. The preparations did not show toxic effects on the liver. The obtained results suggest that theprophylactic use of CDS and CDSM have a significant effect on slowing AA progression, similar to the effect of DF. Both preparationscould be potential preventive or therapeutic candidates for the treatment of autoimmune processes in combination with other drugs.

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