A case of ex vivo boosted immune cell therapy for chronic ulcerative dermatitis in a dog

A 13-year-old castrated male Shih Tzu was presented with recurrent otitis externa and ulcerative dermatitis. Previousinvestigations had failed to identify the cause, and the lesion was resistant to treatment. According to the histopathological examination,a tentative diagnosis of chronic ulcerative dermatitis with bacterial infection was made. To treat the patient, immune cell therapywith antibiotics was conducted every 2 weeks, for a total of six sessions. After treatment, the skin lesion resolved. No side effects wereobserved during therapy. To the best of our knowledge, this is the first case report of the use of immune cell therapy for canine ulcerativedermatitis.

PDF

___

1. Kano R, Maruyama H, Kubota M, Hasegawa A, Kamata H. Chronic ulcerative dermatitis caused by Fusarium sporotrichioides. Med Mycol 2011; 49: 303-305.
2. Bassett R, Burton G, Robson D. Antibiotic responsive ulcerative dermatoses in German Shepherd dogs with mucocutaneous pyoderma. Aust Vet J 2004; 82: 485-489.
3. Olivry T, Rossi MA, Banovic F, Linder KE. Mucocutaneous lupus erythematosus in dogs (21 cases). Vet Dermatol 2015; 26: e256-255.
4. Gross TL, Ihrke PJ, Walder EJ, Affolter VK. Ulcerative and crusting diseases of the epidermis. In: Gross TL, editor. Skin Diseases of the Dog and Cat: Clinical and Histopathologic Diagnosis. Ames, IA, USA: Blackwell Science; 2005. pp. 116- 135.
5. Scott DW, Miller WH, Griffin CE. Miscellaneous skin diseases. In: Muller G, editor. Muller and Kirk’s Small Animal Dermatology. 6th ed. Philadelphia, PA, USA: Saunders. pp. 290-299.
6. Rosenberg SA, Lotze MT. Cancer immunotherapy using interleukin-2 and interleukin-2-activated lymphocytes. Annu Rev Immunol 1986; 4: 681-709.
7. Mie K, Tomihari M, Hoshi K, Nakamura T, Yamaguchi T, Miyahara K, Shimada T. Influence of transfusion of lymphokine-activated T killer cells on inflammatory responses in dogs after laparotomy. J Vet Med Sci 2016; 78: 579-585.
8. Hoshino Y, Takagi S, Osaki T, Okumura M, Fujinaga T. Phenotypic analysis and effects of sequential administration of activated canine lymphocytes on healthy beagles. J Vet Med Sci 2008; 70: 581-588.
9. Rogers NJ, Lechler RI. Allorecognition. Am J Transplant 2001; 1: 97-102.
10. Bangham CR. CTL quality and the control of human retroviral infections. Eur J Immunol 2009; 39: 1700-1712.
11. Boon T, Coulie PG, Van den Eynde BJ, van der Bruggen P. Human T cell responses against melanoma. Annu Rev Immunol 2006; 24: 175-208.
12. Oykhman P, Mody CH. Direct microbicidal activity of cytotoxic T-lymphocytes. J Biomed Biotechnol 2010; 2010: 249482.