The effect of warts on quality of life in Turkish pediatric patients

Background. The negative effect of genital and extragenital warts on adult patient quality of life (QoL) is well known; however, the literature lacks data on the effect of extragenital warts on Turkish pediatric patient QoL. The aim of this study was to determine the effect of extragenital warts that persist for ≥6 months on Turkish pediatric patient QoL, as well as to determine the relationship between patient demographic and clinical characteristics, and QoL.Methods. The Pediatric Quality of Life Inventory Version 4.0 (PedsQLTM 4.0) was administered to 85 children and their parents (patient group), and 85 age- and gender-matched children without any skin disease and their parents (control group). Children’s Dermatology Life Quality Index (CDLQI) was administered to the patients. Higher CDLQI and PedsQLTM are indicative of lower QoL. Results. Median wart duration and median age at the time of wart onset was 12 months (range 6-84) and 10 years (range 1-16), respectively. In the patient group mean (±Standard deviation [SD]) CDLQI score was 5.20 ± 5.97, and warts had the greatest negative effect on CDLQI symptoms and feelings scores. Mean (±SD) PedsQLTM total score was higher in the affected patients than that for the controls (23.42 ± 12.33 versus 15.81 ± 7.37, P

___

1. Kirnbauer R, Lenz P. Human papillomaviruses. In: Bolognia JL, Jorizzo JL, Schaffer JV, (eds). Dermatology (4th ed). London: Saunders, 2018: 1383-1399.

2. Silverberg JI, Silverberg NB. The U.S. prevalence of common warts in childhood: a population-based study. J Invest Dermatol 2013; 133: 2788-2790.

3. Kilkenny M, Merlin K, Young R, Marks R. The prevalence of common skin conditions in Australian school students: 1. Common, plane and plantar viral warts. Br J Dermatol 1998; 138: 840-845.

4. van Haalen FM, Bruggink SC, Gussekloo J, Assendelft WJ, Eekhof JA. Warts in primary schoolchildren: prevalence and relation with environmental factors. Br J Dermatol 2009; 161: 148-152.

5. Drolet M, Brisson M, Maunsell E, et al. The impact of anogenital warts on health-related quality of life: a 6-month prospective study. Sex Transm Dis 2011; 38: 949-956.

6. van der Snoek EM, Couwenberg SM, Lammers AM, van Loon AM. Anogenital warts: influence on quality of life in Dutch soldiers. Sex Transm Dis 2013; 40: 650-651.

7. Sénécal M, Brisson M, Maunsell E, et al. Loss of quality of life associated with genital warts: baseline analyses from a prospective study. Sex Transm Infect 2011; 87: 209-215.

8. Khopkar US, Rajagopalan M, Chauhan AR, et al. Prevalence and burden related to genital warts in India. Viral Immunol 2018; 31: 346-351.

9. Lewis-Jones MS, Finlay AY. The Children’s Dermatology Life Quality Index (CDLQI): initial validation and practical use. Br J Dermatol 1995; 132: 942-949.

10. Balci DD, Sangun O, Inandı T. Cross validation of the Turkish version of Children’s Dermatology Life Quality Index. J Turk Acad Dermatol 2007; 1: 71402a.

11. Beattie PE, Lewis-Jones MS. A comparative study of impairment of quality of life in children with skin disease and children with other chronic childhood diseases. Br J Dermatol 2006; 155: 145-151.

12. Chuh AA. Validation of a Cantonese version of the Children’s Dermatology Life Quality Index. Pediatr Dermatol 2003; 20: 479-481.

13. Olsen JR, Gallacher J, Finlay AY, Piguet V, Francis NA. Quality of life impact of childhood skin conditions measured using the Children’s Dermatology Life Quality Index (CDLQI): a metaanalysis. Br J Dermatol 2016; 174: 853-861.

14. Salek MS, Jung S, Brincat-Ruffini LA, et al. Clinical experience and psychometric properties of the Children’s Dermatology Life Quality Index (CDLQI), 1995-2012. Br J Dermatol 2013; 169: 734-759.

15. Hongbo Y, Thomas CL, Harrison MA, Salek MS, Finlay AY. Translating the science of quality of life into practice: what do dermatology life quality index scores mean? J Invest Dermatol 2005; 125: 659-664.

16. Varni JW, Seid M, Rode CA. The PedsQL: measurement model for the pediatric quality of life inventory. Med Care 1999; 37: 126-139.

17. Nahidi M, Nahidi Y, Saghebi A, et al. Evaluation of psychopathology and quality of life in patients with anogenital wart compared to control Group. Iran J Med Sci 2018; 43: 65-69.

18. Salah E. Impact of multiple extragenital warts on quality of life in immune-competent Egyptian adults: a comparative cross-sectional study. Clin Cosmet Investig Dermatol 2018; 11: 289-295.

19. Manzoni AP, Pereira RL, Townsend RZ, Weber MB, Nagatomi AR, Cestari TF. Assessment of the quality of life of pediatric patients with the major chronic childhood skin diseases. An Bras Dermatol 2012; 87: 361-368.

20. Tekin B, Gurel MS, Topkarci Z, et al. Assessment of quality of life in Turkish children with psoriasis and their caregivers. Pediatr Dermatol 2018; 35: 651-659.

21. Tasoula E, Gregoriou S, Chalikias J, et al. The impact of acne vulgaris on quality of life and psychic health in young adolescents in Greece. Results of a population survey. An Bras Dermatol 2012; 87: 862- 869.

22. Silverberg JI, Silverberg NB. Quality of life impairment in children and adolescents with vitiligo. Pediatr Dermatol 2014; 31: 309-318.

23. Varni JW, Globe DR, Gandra SR, Harrison DJ, Hooper M, Baumgartner S. Health-related quality of life of pediatric patients with moderate to severe plaque psoriasis: comparisons to four common chronic diseases. Eur J Pediatr 2012; 171: 485-492
Turkish Journal of Pediatrics-Cover
  • ISSN: 0041-4301
  • Yayın Aralığı: Yılda 6 Sayı
  • Başlangıç: 1958
  • Yayıncı: Hacettepe Üniversitesi Çocuk Sağlığı Enstitüsü Müdürlüğü
Sayıdaki Diğer Makaleler

Comparative study of various therapeutic modalities for Guillain Barré syndrome in Assiut University Children Hospital

Khaled SAAD, Zeinab M. MOHY-ELDEEN, Ahmad R. AHMAD, Hayam H. MAHRAN

Serum levels of VEGF and bFGF in infantile hemangiomas treated with propranolol

Hilal SUSAM ŞEN, Bilgehan YALÇIN, Hande CANPINAR, Süheyla OCAKV, Canan AKYÜZ

Fecal calprotectin levels in Helicobacter pylori gastritis in children

Özlem Yüksel AKSOY, Oğuz CANAN, Özbay Ferda HOŞNUT, EdaYılmaz AKÇAY, Figen ÖZÇAY

Life-stage factors associated with overweight severity inadolescents

Raziye Dut, Antonio Videira-Silva, Ana Sofia Vilardouro, Silvia Freira, Helena Fonseca

Evaluation of blood pressure responses to treadmill exercise test in normotensive children of hypertensive parents

Gökmen ÖZDEMİR, Pelin KÖŞGER, Birsen UÇAR

Off-label drug use in pediatric patients: a comparative analysis with nationwide routine prescription data

Narin AKICI, Volkan AYDIN, Ahmet AKICI, N. İpek KIRMIZI, Mesil AKSOY, Banu BAYAR

Is being small for gestational age a risk factor for strabismus and refractive errors at 3 years of age?

İkbal Seza PETRİÇLİ, Caner KARA, Ayşegül ARMAN

Peritoneal dialysis as a life-saving procedure in an extremely low birth weight infant: case report and review of the literature

Merih ÇETİNKAYA, Tuğba ERENER ERCAN, Sevgi YAVUZ, Seyithan ÖZAYDIN

A rare pediatric case of neurobrucellosis with bilateral optic neuritis

Cengiz HAVALI, Eren ÇAĞAN

Uncoupling protein gene UCP1-3826A/G, UCP2 Ins/Del and UCP3-55C/T polymorphisms in obese Turkish children

Hasibe VERDİ, Sibel Tulgar KINIK, H. Pınar Baysan ÇEBİ, Yaprak YILMAZ YALÇIN, Ayşe Canan Yazıcı GÜVERCİN, Beril AYDIN, Neslihan Başcıl TÜTÜNCÜ, F. Belgin ATAÇ