Özge BAŞARAN, Sevim KAVUNCU, Alev GÜVEN, Nermin UNCU, Banu ACAR ÇELİKEL, Nilgün ÇAKAR

Familial Mediterranean fever associated with optic neuritis, successfully treated with anti-interleukin 1 agents

Başaran Ö, Kavuncu S, GüvenA, UncuN, Acar-ÇelikelB, Çakar N.Familial Mediterranean fever associated with optic neuritis, successfully treated with anti-interleukin 1 agents. Turk J Pediatr 2016; 58: 327-330.Familial Mediterranean fever (FMF) is an inherited periodic auto-inflammatory disease characterized by recurrent attacks of fever, synovitis and serositis. Ophthalmological manifestations of FMF are extremely rare. Here we described a boy who has been followed-up for FMF and attended with a loss of vision during the course of the disease. He was diagnosed with optic neuritis. As the other etiologies were excluded his optic neuritis was attributed to the underlying auto inflammatory process. After pulse steroid therapy, his symptoms improved and a complete remission occurred. Afterwards he had two more optic neuritis attacks. Thereafter anti-interleukin 1 (IL-1) drugs were introduced and he did not develop further attacks of both optic neuritis and FMF. This case presentation highlights the possible association between FMF and optic nerve involvement.

PDF

___

1. Yalçinkaya F, Ozen S, Ozçakar ZB, et al. A new set of criteria for the diagnosis of familial Mediterranean fever in childhood. Rheumatology 2009; 48: 395-398.

2. Livneh A, Langevitz P, Zemer D, et al. Criteria for the diagnosis of familial Mediterranean fever. Arthritis Rheum 1997; 40: 1879-1885.

3. Kallinich T, Haffner D, Niehues T, et al. Colchicine use in children and adolescents with familial Mediterranean fever: literature review and consensus statement. Pediatrics 2007; 119: e474-e483.

4. D i n a r e l l o C A . I n t e r l e u k i n - 1 b e t a a n d t h e autoinflammatory diseases. N Engl J Med 2009; 360: 2467-2470.

5. Lossos A, Eliashiv S, Ben-Chetrit E, Reches A. Optic neuritis associated with familial Mediterranean fever. J Clin Neuroophthalmol 1993; 13: 141-143.

6. Cakmakli G, Kurne A, Guven A, et al. Childhood optic neuritis: the pediatric neurologist's perspective. Eur J Paediatr Neurol 2009; 13: 452-457.

7. Hirsh A, Huna R, Ashkenazi I, Bartov E, Blumenthal M. Recurrent bilateral panuveitis and rhegmatogenous retinal detachment in a patient with familial Mediterranean fever. Am J Ophthalmol 1990; 110: 702-703.

8. Akman-Demir G, Gul A, Gurol E, et al. Inflammatory/ demyelinating central nervous system involvement in familial Mediterranean fever (FMF): coincidence or association? J Neurol 2006; 253: 928-934.

9. El-Dairi MA, Ghasia F, Bhatti MT. Pediatric optic neuritis. Int Ophthalmol Clin 2012; 52: 29-49.

10. Costello F. Inflammatory optic neuropathies. Continuum (Minneap Minn) 2014; 20: 816-837.

11. Collinge JE, Sprunger DT. Update in pediatric optic neuritis. Curr Opin Ophthalmol 2013; 24: 448-452.

12. Tang WQ, Wei SH. Primary Sjögren's syndrome related optic neuritis. Int J Ophthalmol 2013; 6: 888-891

13. Pyo JY, Park JS, Song CH, Lee SW, Park YB, Lee SK. Takayasu arteritis associated with ulcerative colitis and optic neuritis: first case in Korea. Korean J Intern Med 2013; 28: 491-496.

14. Frigui M, Frikha F, Sellemi D, Chouayakh F, Feki J, Bahloul Z. Optic neuropathy as a presenting feature of systemic lupus erythematosus: two case reports and literature review. Lupus 2011; 20: 1214-1218.

15. Wingerchuk DM, Weinshenker BG. The emerging relationship between neuromyelitis optica and systemic rheumatologic autoimmune disease. Mult Scler 2012; 18: 5-10.

16. Palopoli JJ, Waxman J. Colchicine neuropathy or vitamin B12 deficiency neuropathy? N Engl J Med 1987; 317: 1290-1291.