Young Mi HAN, Na Rae LEE, Mi Hye BAE, Kyung Hee PARK, Yun Jin LEE, Shin Yun BYUN, Sang OOK

Establishing reference values for amplitude-integrated electroencephalography in preterms below 35 weeks of gestational age: A prospective observational cohort study

Han YM, Lee NR, Bae MH, Park KH, Lee YJ, Nam SO, Byun SY.Establishing reference values for amplitude-integrated electroencephalographyin preterms below 35 weeks of gestational age: A prospective observationalcohort study. Turk J Pediatr 2016; 58: 592-601.Characteristic patterns in amplitude-integrated electroencephalography (aEEG)develop with gestational age (GA), and so can be used to evaluate brainmaturation in premature infants. Reference aEEG values in normal preterminfants have not been identified and data are scarce. We aimed to validate acurrently available aEEG scoring system. We also investigated the developmentof aEEG activity during the first week after birth, determining referencevalues in preterm infants with no abnormal cranial ultrasound findings. Weprospectively studied aEEG and cranial ultrasounds in infants with a GA of

PDF

___

Stoll BJ, Hansen NI, Bell EF, et al. Trends in care practices, morbidity, and mortality of extremely preterm neonates, 1993-2012. JAMA 2015; 314: 1039-1051.
Azzopardi D. Clinical applications of cerebral function monitoring in neonates. Semin Fetal Neonatal Med 2015; 20: 154-163.
Bjerre I, Hellstrom-Westas L, Rosen I, Svenningsen N. Monitoring of cerebral function after severe asphyxia in infancy. Arch Dis Child 1983; 58: 997-1002.
Simbruner G, Mittal RA, Rohlmann F, Muche R; neo.nEURO.network Trial Participants. Systemic hypothermia after neonatal encephalopathy: Outcomes of neo.nEURO.network RCT. Pediatrics 2010; 126: e771-778.
Sohn JA, Kim HS, Lee EH, et al. Developmental change of amplitude-integrated electroencephalographic activity in preterm infants with intraventricular hemorrhage. Early Hum Dev 2013; 89: 961-966.
van den Berg E, Lemmers PM, Toet MC, Klaessens JH, van Bel F. Effect of the “InSurE” procedure on cerebral oxygenation and electrical brain activity of the preterm infant. Arch Dis Child Fetal Neonatal Ed 2010; 95: F53-58.
Soubasi V, Mitsakis K, Sarafidis K, Griva M, Nakas CT, Drossou V. Early abnormal amplitude-integrated electroencephalography (aEEG) is associated with adverse short-term outcome in premature infants. Eur J Paediatr Neurol 2012; 16: 625-630.
Sisman J, Campbell DE, Brion LP. Amplitude-integrated EEG in preterm infants: maturation of background pattern and amplitude voltage with postmenstrual age and gestational age. J Perinatol 2005; 25: 391-396.
Lee HJ, Kim HS, Kim SY, et al. Effects of postnatal age and aminophylline on the maturation of amplitude- integrated electroencephalography activity in preterm infants. Neonatology 2010; 98: 245-253.
Burdjalov VF, Baumgart S, Spitzer AR. Cerebral function monitoring: a new scoring system for the evaluation of brain maturation in neonates. Pediatrics 2003; 112: 855-861.
Griesmaier E, Burger C, Ralser E, Neubauer V, Kiechl-Kohlendorfer U. Amplitude-integrated electroencephalography shows mild delays in electrocortical activity in preterm infants born small for gestational age. Acta Paediatr 2015; 104: e283-288.
Papile LA, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: A study of infants with birth weights less than 1,500 gm. J Pediatr 1978; 92: 529-534.
de Vries LS, Eken P, Dubowitz LM. The spectrum of leukomalacia using cranial ultrasound. Behav Brain Res 1992; 49: 1-6.
Fenton TR, Kim JH. A systematic review and meta- analysis to revise the Fenton growth chart for preterm infants. BMC Pediatr 2013; 13: 59.
Hellstrom-Westas L, Rosen I. Continuous brain-function monitoring: state of the art in clinical practice. Semin Fetal Neonatal Med 2006; 11: 503-511.
Olischar M, Klebermass K, Kuhle S, et al. Reference values for amplitude-Integrated electroencephalographic activity in preterm infants younger than 30 weeks’ gestational age. Pediatrics 2004; 113: 61-66.
Hellström-Westas L, Rosén I, de Vries LS, Greisen G. Amplitude-integrated EEG classification and interpretation in preterm and term infants. NeoReviews 2006; 7: e76-e87.
Soubasi V, Mitsakis K, Nakas CT, et al. The influence of extrauterine life on the aEEG maturation in normal preterm infants. Early Hum Dev 2009; 85: 761-765.
al Naqeeb N, Edwards AD, Cowan FM, Azzopardi D. Assessment of neonatal encephalopathy by amplitude- integrated electroencephalography. Pediatrics 1999; 103: 1263-1271.
Yerushalmy-Feler A, Marom R, Peylan T, et al. Electroencephalographic characteristics in preterm infants born with intrauterine growth restriction. J Pediatr 2014; 164: 756-761.
ter Horst HJ, Jongbloed-Pereboom M, van Eykern LA, Bos AF. Amplitude-integrated electroencephalographic activity is suppressed in preterm infants with high scores on illness severity. Early Hum Dev 2011; 87: 385-390.
Benavente-Fernandez I, Lubian-Lopez SP, Jimenez- Gomez G, Lechuga-Sancho AM, Garcia-Alloza M. Low-voltage pattern and absence of sleep-wake cycles are associated with severe hemorrhage and death in very preterm infants. Eur J Pediatr 2015; 174: 85-90.
Andre M, L amblin MD, d’Allest AM, et al. Electroencephalography in premature and full- term infants. Developmental features and glossary. Neurophysiol Clin 2010; 40: 59-124.
Connell JA, Oozeer R, Dubowitz V. Continuous 4-channel EEGmonitoring: a guide to interpretation, with normal values, in preterm infants. Neuropediatrics 1987; 18: 138-145.
Selton D, Andre M, Hascoët J. Normal EEG in very premature infants: Reference criteria. Clin Neurophysiol 2000; 111: 2116-2124.
Kuhle S, Klebermass K, Olischar M, et al. Sleep-wake cycles in preterm infants below 30 weeks of gestational age. Preliminary results of a prospective amplitude- integrated EEG study. Wien Klin Wochenschr 2001; 113: 219-223.
Scher MS, Johnson MW, Holditch-Davis D. Cyclicity of neonatal sleep behaviors at 25 to 30 weeks’ postconceptional age. Pediatr Res 2005; 57: 879-882.
Vecchierini MF, André M, d’Allest AM. Normal EEG of premature infants born between 24 and 30weeks gestational age: Terminology, definitions andmaturation aspects. Neurophysiol Clin 2007; 37: 311-323.
Ozdemir OM, Ergin H, Sahiner T. Electrophysiological assessment of the brain function in term SGA infants. Brain Res 2009; 1270: 33-38.
Kazanci E, Gucuyener K, Ergenekon E, Aktas S. Functional brain maturation of prematurely born, growth discordant monochorionic twins assessed by aEEG. Brain and Development 2016; 38: 100-102.