Meriç KAYMAK-CİHAN, Olcay KANDEMİR, Klara DALVA, Neriman SARI, İNCİ ERGÜRHAN İLHAN

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Can Burkitt's Lymphoma and Hodgkin's Lymphoma occur in siblings simultaneously?

Kaymak-Cihan M, Kandemir O, Dalva K, Sarı N, Kurucu N, Ergürhan-İlhan İ. Can Burkitt's lymphoma and Hodgkin's lymphoma occur in siblings simultaneously? Turk J Pediatr 2015; 57: 536-540.Familial clustering of Hodgkin lymphoma (HL) and increased risk of developing disease among the siblings has been reported earlier. Usually familial lymphoma in sibling pairs occurs in the pairs of either non-Hodgkin lymphoma or HL. In the familial HL, same type of human leukocyte antigens (HLA) is responsible in the affected family members. There are also some studies stating "Killer cell immunoglobulin like receptor (KIR)" genotypes can be important in the etiology of familial HL. Here we report two siblings; one with Non-Hodgkin and the other with Hodgkin lymphoma which showed Epstein-Barr virus encoded small RNAs positivity in the tumor tissues. We have also found that their HLA genotypes are same with each other. In addition, we have discussed familial lymphoma pathogenesis and HLA haplotypes.

Meriç Kaymak-Cihan1, Olcay Kandemir2, Klara Dalva3, Neriman Sarı4, Nilgün Kurucu4, İnci Ergürhan-İlhan4

Kaymak-Cihan M, Kandemir O, Dalva K, Sarı N, Kurucu N, Ergürhan-İlhan İ. Can Burkitt's lymphoma and Hodgkin's lymphoma occur in siblings simultaneously? Turk J Pediatr 2015; 57: 536-540.Familial clustering of Hodgkin lymphoma (HL) and increased risk of developing disease among the siblings has been reported earlier. Usually familial lymphoma in sibling pairs occurs in the pairs of either non-Hodgkin lymphoma or HL. In the familial HL, same type of human leukocyte antigens (HLA) is responsible in the affected family members. There are also some studies stating "Killer cell immunoglobulin like receptor (KIR)" genotypes can be important in the etiology of familial HL. Here we report two siblings; one with Non-Hodgkin and the other with Hodgkin lymphoma which showed Epstein-Barr virus encoded small RNAs positivity in the tumor tissues. We have also found that their HLA genotypes are same with each other. In addition, we have discussed familial lymphoma pathogenesis and HLA haplotypes.
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19. Harty LC, Lin AY, Goldstein AM, et al. HLA_DR, HLA_DQ and TAP genes in familial Hodgkin disease. Blood 2002; 99: 690-693.

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Turkish Journal of Pediatrics-Cover
  • ISSN: 0041-4301
  • Yayın Aralığı: Yılda 6 Sayı
  • Başlangıç: 1958
  • Yayıncı: Hacettepe Üniversitesi Çocuk Sağlığı Enstitüsü Müdürlüğü
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