Allergen variability and house dust mite sensitivity in pre-school children with allergic complaints
Allergen variability and house dust mite sensitivity in pre-school children with allergic complaints
Yazıcı S, Güneş S, Kurtuluş-Çokboz M, Kemer Ö, Baranlı G,Aşık-Akman S, Can D. Allergen variability and house dust mite sensitivity inpre-school children with allergic complaints. Turk J Pediatr 2018; 60: 41-49.The increase in the prevalence of allergic diseases in pre-school children whoare often at home may be due to an increase in house dust mite sensitivity,which is rarely expected in this age group. In our study, it was aimed toinvestigate allergen sensitivities, especially house dust mite sensitivity inpre-school children with allergic disease complaints by skin prick test (SPT).Two hundred and twenty children admitted to the Pediatric Allergy andAsthma Clinic of Balıkesir University between October 2015 and October2016 diagnosed with asthma, allergic rhinitis, food allergy, atopic dermatitisor urticaria were involved in the retrospective cross-sectional study. Allergengroups used in SPT were Dermatophagoides farina (Derf), Dermatophagoidespteronyssinus (Der p), Alternaria alternata, cat epithelium, pollen mixture andfood mixture.Average age of the 220 patients was 2.98 years (2.75-3.21). SPT was positivein 55.9% of patients. Sixteen percent were monosensitized and 73.8% werepolysensitized. Seventy two children (32.7%) were sensitive to Der f and67 (30.4%) were sensitive to Der p. There was no difference between SPTpositivity and gender (p>0.05). Ninty-five children were diagnosed withasthma, 38 with asthma and allergic rhinitis, 63 with food allergy and 24with urticaria and/or atopic dermatitis. SPT positivity was significantly higherin the asthma and allergic rhinitis group than other groups. As the ageincreased, significant increases in the sensitivities of Der f (p
___
- 1. LeMasters GK, Wilson K, Levin L, et al. High prevalence of aeroallergen sensitization among infants of atopic parents. J Pediatr 2006; 149: 505-511.
- 2. Sheehan WJ, Rangsithienchai PA, Baxi SN, et al. Agespecific prevalence of outdoor and indoor aeroallergen sensitization in Boston. Clin Pediatr 2010; 49: 579-585.
- 3. Ogershok PR, Warner DJ, Hogan MB, et al. Prevalence of pollen sensitization in younger children who have asthma. Allergy Asthma Proc 2007; 28: 654-658.
- 4. Lin H, Lin R, Li N. Sensitization Rates for Various Allergens in Children with Allergic Rhinitis in Qingdao, China. Int J Environ Res Public Health 2015; 12: 10984-10994.
- 5. Dean T, Venter C, Pereira B, et al. Patterns of sensitization to food and aeroallergens in the first 3 years of life. J Allergy Clin Immunol 2007; 120: 1166-1171.
- 6. Kottek M, Grieser J, Beck C, et al. World map of the Koeppen-Geiger climate classification updated. Meteorol Z 2006; 15: 263.
- 7. Kim J, Hahm MI, Lee SY. Sensitization to aeroallergens in Korean children: a population-based study in 2010. J Korean Med Sci 2011; 26: 1165-1172.
- 8. Torrent M, Sunyer J, Garcia R. et. al. Early-life allergen exposure and atopy, asthma, and wheeze up to 6 years of age. Am J Respir Crit Care Med 2007; 176 : 446- 453.
- 9. Civelek E, Sahiner UM, Yüksel H, et. al. Prevalence, burden, and risk factors of atopic eczema in schoolchildren aged 10-11 years: a national multicenter study. J Investig Allergol Clin Immunol 2011; 21: 270-277.
- 10. Kuyucu S, Saraçlar Y, Tuncer A, et al. Determinants of atopic sensitization in Turkish school children: effects of pre- and post-natal events and maternal atopy. Pediatr Allergy Immunol 2004; 15: 62-71.
- 11. Burbach GJ, Heinzerling LM, Edenharter G. GA(2)12. Akcakaya N, Cokugras H, Camcioglu Y, Ozdemir M. Skin test hypersensitivity for childhood asthma in Istanbul during a period of 16 years. Allergol Immunopathol 2005; 33: 15-19. 13. Dibek Mısırlıoğlu D, Reha Cengizlier M. Skin prick test results of child patients diagnosed as bronchial asthma. Allergol Immunopathol (Madr) 2007; 35: 21- 24. 14. Şahiner UM, Civelek E, Yavuz ST, et al. Skin prick testing to aeroallergen extracts: what is the optimal panel in children and adolescents in Turkey? Int Arch Allergy Immunol 2012; 157: 391-398. 15. Sahiner UM, Buyuktiryaki AB, Yavuz ST, et al. The spectrum of aeroallergen sensitization in children diagnosed with asthma during first 2 years of life. Allergy Asthma Proc 2013; 34: 356-361. 16. Ozkaya E, Sogut A, Küçükkoç M, et al. Sensitization pattern of inhalant allergens in children with asthma who are living different altitudes in Turkey. Int J Biometeorol 2015; 59: 1685-1690.12. Akcakaya N, Cokugras H, Camcioglu Y, Ozdemir M. Skin test hypersensitivity for childhood asthma in Istanbul during a period of 16 years. Allergol Immunopathol 2005; 33: 15-19. 13. Dibek Mısırlıoğlu D, Reha Cengizlier M. Skin prick test results of child patients diagnosed as bronchial asthma. Allergol Immunopathol (Madr) 2007; 35: 21- 24. 14. Şahiner UM, Civelek E, Yavuz ST, et al. Skin prick testing to aeroallergen extracts: what is the optimal panel in children and adolescents in Turkey? Int Arch Allergy Immunol 2012; 157: 391-398. 15. Sahiner UM, Buyuktiryaki AB, Yavuz ST, et al. The spectrum of aeroallergen sensitization in children diagnosed with asthma during first 2 years of life. Allergy Asthma Proc 2013; 34: 356-361. 16. Ozkaya E, Sogut A, Küçükkoç M, et al. Sensitization pattern of inhalant allergens in children with asthma who are living different altitudes in Turkey. Int J Biometeorol 2015; 59: 1685-1690. LEN skin test study II: clinical relevance of inhalant allergen sensitizations in Europe. Allergy 2009; 64: 1507-1515.
- 12. Akcakaya N, Cokugras H, Camcioglu Y, Ozdemir M. Skin test hypersensitivity for childhood asthma in Istanbul during a period of 16 years. Allergol Immunopathol 2005; 33: 15-19.
- 13. Dibek Mısırlıoğlu D, Reha Cengizlier M. Skin prick test results of child patients diagnosed as bronchial asthma. Allergol Immunopathol (Madr) 2007; 35: 21- 24.
- 14. Şahiner UM, Civelek E, Yavuz ST, et al. Skin prick testing to aeroallergen extracts: what is the optimal panel in children and adolescents in Turkey? Int Arch Allergy Immunol 2012; 157: 391-398.
- 15. Sahiner UM, Buyuktiryaki AB, Yavuz ST, et al. The spectrum of aeroallergen sensitization in children diagnosed with asthma during first 2 years of life. Allergy Asthma Proc 2013; 34: 356-361.
- 16. Ozkaya E, Sogut A, Küçükkoç M, et al. Sensitization pattern of inhalant allergens in children with asthma who are living different altitudes in Turkey. Int J Biometeorol 2015; 59: 1685-1690.