Semanur ÖZDAL, Mesiha EKİM, Gülşah KAYGUSUZ, Elif ÇELİKEL, Göksel VATANSEVER, Nurdan TAÇYILDIZ

A new location for pediatric immunoglobulin G4 related disease: the biceps muscle

Background. Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is a systemic disorder of unknown etiology characterized by elevated serum IgG4 and tissue infiltration of IgG4-positive plasma cells. The disease was described in the pancreas, aorta, thyroid, salivary glands, periorbital tissues, kidneys, pericardium and lymph nodes. Case. Here in, we report a first pediatric case report of IgG4-related disease who presented with a mass in skeletal muscle i.e., biceps muscle.Conclusion. To the best of our knowledge, the involvement in skeletal muscle has previously not been reported in children.

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1. Umehara H, Okazaki K, Masaki Y, et al; Research Program for Intractable Disease by Ministry of Health, Labor and Welfare (MHLW) Japan G4 team. A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details. Mod Rheumatol 2012; 22: 1-14.

2. Stone JH, Khosroshahi A, Hilgenberg A, Spooner A, Isselbacher EM, Stone JR. IgG4-related systemic disease and lymphoplasmocytic aortitis. Arthritis Rheum 2009; 60: 3139-3145.

3. Stone JH, Zen Y, Deshpande V. IgG4-related disease. N Engl J Med 2012; 366: 539-551.

4. Hamano H, Kawa S, Horiuchi A, et al. High serum IgG4 concentrations in patients with sclerosing pancreatitis. N Engl J Med 2001; 344: 732-738.

5. Kamisawa T, Funata N, Hayashi Y, et al. A new clinicopathological entity of IgG4-related autoimmune disease. J Gastroenterol 2003; 38: 982- 984.

6. Sah RP, Chari ST. Serologic issues in IgG4-related systemic disease and autoimmune pancreatitis. Curr Opin Rheumatol 2011; 23: 108-113.

7. Stone JH, Khosroshahi A, Deshpande V, et al. Recommendations for the nomenclature of IgG4- related disease and its individual organ system manifestations. Arthritis Rheum 2012; 64: 3061-3067.

8. Pace C, Ward S. A rare case of IgG4-related sclerosing disease of the maxillary sinus associated with bone destruction. J Oral Maxillofac Surg 2010; 68: 2591- 2593.

9. Masaki Y, Kurose N, Umehara H. IgG4-related disease: a novel lymphoproliferative disorder discovered and established in Japan in the 21st century. J Clin Exp Hematop 2011; 51: 13-20.

10. Palazzo E, Palazzo C, Palazzo M. IgG4-related disease. Joint Bone Spine 2014; 81: 27-31.

11. Khosroshahi A, Carruthers MN, Deshpande V, Unizony S, Bloch DB, Stone JH. Rituximab for the treatment of IgG4-related disease: lessons from 10 consecutive patients. Medicine (Baltimore) 2012; 91: 57-66.

12. Khan ML, Colby TV, Viggiano RW, Fonseca R. Treatment with bortezomib of a patient having hyper IgG4 disease. Clin Lymphoma Myeloma Leuk 2010; 10: 217-219.