Uğur KÜÇÜK, Ferhat CÜCE, Özay DEMİRAY, Hilal OLGUN KÜÇÜK

Varicocele: tissue stress in the etiology

Background/aim: It is accepted that red blood cell distribution width (RDW) is a novel prognostic marker that reflects oxidative stress and chronic inflammation. In this study, we aimed to investigate the correlation between RDW and varicocele, the etiology of which has not fully elucidated yet. This study also aimed to study the mean platelet volume (MPV) values of the patient and control group. Materials and methods: RDW and MPV levels were measured in 50 varicocele subjects (group 1) and 48 healthy controls (group 2) from January 2012 to January 2014, retrospectively. Results: MPV levels were significantly higher in group 1 than in group 2 (P < 0.001). Although the relationship was weak, the patients with varicocele had significantly lower RDW values than did the controls (r: 0.24 P = 0.026). Positive correlations were not found between varicocele grade and MPV and RDW values (P < 0.05) Conclusion: Higher MPV values are associated with increased odds of developing varicocele.

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1. Kantartzi PD, Goulis ChD, Goulis GD, Papadimas I. Male infertility and varicocele: myths and reality. Hippokratia 2007; 11: 99-104.
2. Befeler B, Aranda MJ, Embi A, Mullin FL, El-Sherif N, Lazzara R. Coronary artery aneurysms: study of the etiology, clinical course and effect on left ventricular function and prognosis. Am J Med 1977; 62: 597-607.
3. Triantafillidi H, Rizos I, Androulakis A, Stratos K, Arvaniti C, Toutouzas P. Coronary artery ectasia, aneurysm of the basilar artery and varicose veins: common presentation or generalized defect of the vessel wall? A case report. Angiology 2001; 52: 287-291.
4. Yetkin E, Kilic S, Acikgoz N, Ergin H, Aksoy Y, Sincer I, Aktürk E, Beytur A, Sivri N, Turhan H. Increased prevalence of varicocele in patients with coronary artery ectasia. Coron Artery Dis 2005; 16: 261-264.
5. Androulakis AE, Katsaros AA, Kartalis AN, Stougiannos PN, Andrikopoulos GK, Triantafyllidi EI, Pantazis AA, Stefanadis CI, Kallikazaros IE. Varicose veins are common in patients with coronary artery ectasia. Just a coincidence or a systemic deficit of the vascular wall? Eur J Vasc Endovasc Surg 2004; 27: 519-524
6. Bonomini F, Rodella LF, Rezzani R. Metabolic syndrome, aging and involvement of oxidative stress. Aging Dis 2015; 6: 109- 120.
7. Semba RD, Patel KV, Ferrucci L, Sun K, Roy CN, Guralnik JM, Fried LP. Serum antioxidants and inflammation predict red cell distribution width in older women: The Womens Health and Aging Study I. Clin Nutr 2010; 29: 600-604.
8. Tsuboi S, Miyauchi K, Kasai T, Ogita M, Dohi T, Miyazaki T, Yokoyama T, Kojima T, Yokoyama K, Kurata T et al. Impact of red blood cell distribution width on long-term mortality in diabetic patients after percutaneous coronary intervention. Circ J 2013; 77: 456-461.
9. Malandrino N, Wu WC, Taveira TH, Whitlatch HB, Smith RJ. Association between red blood cell distribution width and macrovascular and microvascular complications in diabetes. Diabetologia 2012; 55: 226-235.
10. Bozkurt Y, Soylemez H, Sancaktutar AA, Islamoglu Y, Kar A, Penbegul N, Atar M, Bodakci MN, Hatipoglu NK. Relationship between mean platelet volume and varicocele: a preliminary study. Urology 2012; 79: 1048-1051.
11. Çoban S, Keleş İ, Bıyık İ, Güzelsoy M, Türkoğlu AR, Özgünay T, Ocak N. Is there any relationship between mean platelet volume and varicocele? Andrologia 2015; 47: 37-41.
12. Tesfamariam B, Cohen RA. Free radicals mediate endothelial cell dysfunction caused by elevated glucose. Am J Physiol 1992; 263: 321-326.
13. King GL, Loeken MR. Hyperglycemia-induced oxidative stress in diabetic complications. Histochem Cell Biol 2004; 122: 333- 338.
14. Friedman JS, Lopez MF, Fleming MD, Rivera A, Martin FM, Welsh ML, Boyd A, Doctrow SR, Burakoff SJ. SOD2-deficiency anemia: protein oxidation and altered protein expression reveal targets of damage, stress response, and antioxidant responsiveness. Blood 2004; 104: 2565-2573.
15. Lippi G, Targher G, Montagnana M, Salvagno GL, Zoppini G, Guidi GC. Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients. Arch Pathol Lab Med 2009; 133: 628-632.
16. Yeun JY, Kaysen GA. C-reactive protein, oxidative stress, homocysteine, and troponin as inflammatory and metabolic predictors of atherosclerosis in ESRD. Curr Opin Nephrol Hypertens 2000; 9: 621-630.
17. Felker GM, Allen LA, Pocock SJ Shaw LK, McMurray JJ, Pfeffer MA, Swedberg K, Wang D, Yusuf S, Michelson EL et al. Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Program and the Duke Databank. J Am Coll Cardiol 2007; 50: 40-47.
18. Tonelli M, Sacks F, Arnold M, Moye L, Davis B, Pfeffer M. Relation between red blood cell distribution width and cardiovascular event rate in people with coronary disease. Circulation 2008; 117: 163-168.
19. Patel KV, Ferrucci L, Ershler WB, Longo DL, Guralnik JM. Red blood cell distribution width and the risk of death in middleaged and older adults. Arch Intern Med 2009; 169: 515-523.
20. Perlstein TS, Weuve J, Pfeffer MA, Beckman JA. Red blood cell distribution width and mortality risk in a community based prospective cohort. Arch Intern Med 2009; 169: 588-594.
21. Wellen KE, Hotamisligil GS. Inflammation, stress, and diabetes. J Clin Invest 2005; 115: 1111-1119.
22. Saito I. Epidemiological evidence of type 2 diabetes mellitus, metabolic syndrome, and cardiovascular disease in Japan. Circ J 2012; 76: 1066-1073.
23. Gokce A, Demirtas A, Ozturk A, Sahin N, Ekmekcioglu O. Association of left varicocoele with height, body mass index and sperm counts in infertile men. Andrology 2013; 1: 116- 119.
24. Yigitler C, Yanardag H, Silit E, Alpay AS. Evaluation of inguinoscrotal pathologies among adolescents with special emphasis on association between varicocele and body mass index. Urol J 2012; 9: 592-599.