The relationship of breast arterial calcification detected in mammographic examinations with cardiovascular diseases, cardiovascular risk factors, parity, and breastfeeding
The relationship of breast arterial calcification detected in mammographic examinations with cardiovascular diseases, cardiovascular risk factors, parity, and breastfeeding
Background/aim: We aimed to detect the incidence of breast arterial calcification (BAC) in patients that underwent mammography and to reveal the relationship of BAC with cardiovascular diseases, cardiovascular risk factors, parity, and breastfeeding. Materials and methods: A total of 1195 female patients were included in this study. Cases that were positive for BAC during mammography were recorded. The relationship of BAC with age, body mass index, parity, breastfeeding, menopause, smoking, alcohol consumption, oral contraceptive use, hormone replacement therapy, and histories of hypertension (HT), diabetes mellitus (DM), coronary artery disease (CAD), and cerebral vascular diseases were investigated. Results: Overall, 97 of 1195 cases were positive for BAC. In univariate analysis, age, educational status, parity, breastfeeding, menopause, hyperlipidemia, and DM, HT, and CAD histories were found to be separate risk factors that had an effect on the development of BAC. The effects of age, parity, and breastfeeding history were maintained in the logistic regression analysis (P = 0.001, P = 0.001, P = 0.024, respectively; P < 0.05 was significant), while the significance of the other analyzed variables was lost (P > 0.05).
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- 1. Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL. Harrisons Principles of Internal Medicine. 15th ed. New York, NY, USA: McGraw-Hill; 2001. pp. 13771387.
- 2. Maas AHEM, van der Schouw YT, Beijerinck D, Deurenberg JJM, Mali WPTM, van der Graaf Y. Arterial calcifications seen on mammograms: cardiovascular risk factors, pregnancy and lactation. Radiology 2006; 240: 3338.
- 3. Blackman G, Andreeva L, Coughlin BF, March DE, Makari-Judson G, Frank J. Breast arterial calcifications on mammography: incidence in various age groups. Radiology 2002; 225: 553.
- 4. Rotter MA, Schnatz PF, Currier AA, OSullivan DM. Breast arterial calcifications found on screening mammography and their association with cardiovascular disease. Menopause 2008; 15: 276281.
- 5. Iribarren C, Go AS, Tolstykh I, Sidney S, Johnston SC, Spring DB. Breast vascular calcification and risk of coronary heart disease, stroke, and heart failure. J Womens Health 2004; 13: 381389.
- 6. Dale PS, Richards M, Mackie GC. Vascular calcifications on screening mammography identify women with increased risk of coronary artery disease and diabetes. Am J Surg 2008; 196: 537540.
- 7. Schnatz PF, Marakovits KA, OSullivan DM. The association of breast arterial calcification and coronary heart disease. Obstet Gynecol 2011; 117: 233241.
- 8. Maas AH, van der Schouw YT, Mali WP, van der Graaf Y. Prevalence and determinants of breast arterial calcium in women at high risk of cardiovascular disease. Am J Cardiol 2004; 94: 655659.
- 9. Sedighi N, Radmard AR, Radmehr A, Hashemi P, Hajizadeh A, Taheri AP. Breast arterial calcification and risk of carotid atherosclerosis: focusing on the preferentially affected layer of the vessel wall. Eur J Radiol 2011; 79: 250256.
- 10. Henkin Y, Abu-Ful A, Shai I, Crystal P. Lack of association between breast artery calcification seen on mammography and coronary artery disease on angiography. J Med Screen 2003; 10: 139142.
- 11. Kim H, Greenberg JS, Javitt MC. Breast calcifications due to Monckeberg medial calcific sclerosis. Radiographics 1999; 19: 14011403.
- 12. Crystal P, Zelingher J, Crystal E. Breast arterial calcifications as a cardiovascular risk marker in women. Expert Rev Cardiovasc Ther 2004; 2: 753760.
- 13. Ratti C, Chiurlia E, Grimaldi T, Barbieri A, Romagnoli R, Modena MG. Breast arterial calcifications and coronary calcifications: a common link with atherosclerotic subclinical disease. Ital Heart J Suppl 2005; 6: 569574.
- 14. Baum JK, Cornstock CH, Joseph L. Intramammary arterial calcification associated with diabetes. Radiology 1980; 136: 6162.
- 15. Kataoka M, Warren R, Luban R, Camus J, Denton E, Sala E, Day N, Khaw KT. How predictive is breast arterial calcification of cardiovascular disease and risk factors when found at screening mammography? Am J Roentgenol 2006; 187: 7380.
- 16. Moshyedi AC, Puthawala AH, Kurland RJ, OLeary DH. Breast arterial calcification: Association with coronary artery disease. Work in progress. Radiology 1995; 194: 181183.
- 17. Taşkın F, Akdilli A, Karaman C, Ünsal A, Köseoğlu K, Ergin F. Mammographically detected breast arterial calcifications: indicators for arteriosclerotic diseases? Eur J Radiol 2006; 60: 250255.
- 18. Akinola RA, Ogbera OA, Onakoya JAA, Enabulele CE, Fadeyibi IO. Mammograms and breast arterial calcifications: looking beyond cancer: a preliminary report. BMC Res Notes 2011; 4: 207.
- 19. Loberant N, Salamon V, Carmi N, Chernihovsky A. Prevalence and degree of breast arterial calcifications on mammography: a cross-sectional analysis. J Clin Imaging Sci 2013. 3: 36.
- 20. Kataoka M, Warren R, Luben R, Camus J, Denton E, Sala E, Day N, Khaw KT. How predictive is breast arterial calcification of cardiovascular disease and risk factors when found at screening mammography? Am J Roentgenol 2006; 187: 7380.
- 21. Peterson HB, Lee NC. Long-term health risks and benefits of oral contraceptive use. Obstet Gynecol Clin North Am 1990; 17: 775788.
- 22. Hodis HN, Mack WJ, Lobo RA, Shoupe D, Sevanian A, Mahrer PR, Selzer RH, Liu CR, Liu CH, Azen SP. Estrogen in the prevention of atherosclerosis. A randomized, double blind, placebo-controlled trial. Ann Intern Med 2001; 135: 939953.
- 23. Ak M, Sivrioğlu AK, Sönmez G, İncedayi M, Aribal S, Sağlam M, Mutlu H, Sarı S. Investigation of the risk of cardiovascular disease in patients wıth breast artery calcification. Anatol J Clin Investig 2012; 6: 246250.