The frequency of Achilles and plantar calcaneal spurs in gout patients

The frequency of Achilles and plantar calcaneal spurs in gout patients

Background/aim: Gout may cause various radiographic abnormalities such as cartilage loss, spurs, sclerosis, and periostal new bone formation. The purpose of this study was to investigate the frequency of Achilles and plantar spurs and related factors in gout patients. Matherial and methods: We performed a retrospective review of gout patients, treated at Hacettepe University hospitals between 2014 and 2019. We identified patients from the hospital records using the ICD-10 code (M10). Demographic and clinical features, comorbidities, and foot radiographies were collected. The radiographies were evaluated by a rheumatologist (U.K.) who was experienced in musculoskeletal radiography. Factors predicting the spurs were analyzed by logistic regression analysis. Results: 181 patients who had lateral foot radiograph were included in this study. Eighty-one (44.7%) patients had score ≥ 2 Achilles spur, 81 (44.7%) patients had score ≥ 2 plantar spur, and 22 (12.1%) patients had no spur. Age, disease duration, duration between the gout diagnosis and appearing spur, the presence of metabolic comorbidities and hypertension were higher in both Achilles and plantar spurs than no spur group. Forty (22.1%) patients had score ≥ 2 both Achilles and plantar spur. In this group, the mean age was older and the proportion of metabolic comorbidities was higher than the groups of Achilles and plantar spur with a score 0 or 1. Predictor of the development of large or moderate-severe calcaneal spur was the existence of metabolic comorbidity [OR (95% CI): 3.49 (1.11–11.0) and p = 0.033]. Conclusion: The presence of metabolic comorbidities increases the frequency of calcaneal spurs in gout patients. This condition can be explained by the impaired microvascular structure and increased hypoxia resulting in calcification on the tendon and ligament insertion sites.Key words: Gout, Achilles tendon, bone spurs, comorbidity

___

  • 1. Faires JS, Mccarty DJ. Acute arthritis in man and dog after intrasynovial injection of sodium urate crystals. The Lancet 1962; 280 (7258): 682-685. doi: 10.1016/S0140-6736(62)90501-9
  • 2. Richette P, Doherty M, Pascual E, Barskova V, Becce F et al. 2018 updated European League against rheumatism evidencebased recommendations for the diagnosis of gout. Annals of the Rheumatic Diseases 2020; 79 (1): 31-38. doi: 10.1136/ annrheumdis-2019-215315
  • 3. Dalbeth N, House ME, Aati O, Tan P, Franklin C et al. Urate crystal deposition in asymptomatic hyperuricaemia and symptomatic gout: a dual energy CT study. Annals of the Rheumatic Diseases 2015; 74 (5): 908-911. doi: 10.1136/ annrheumdis-2014-206397
  • 4. De Miguel E, Puig JG, Castillo C, Peiteado D, Torres RJ et al. Diagnosis of gout in patients with asymptomatic hyperuricaemia: a pilot ultrasound study. Annals of the Rheumatic Diseases 2012; 71 (1): 157-158. doi: 10.1136/ard.2011.154997
  • 5. Taylor WJ, Fransen J, Jansen TL, Dalbeth N, Schumacher HR et al. Study for updated gout classification criteria: identification of features to classify gout. Arthritis Care & Research (Hoboken) 2015; 67 (9): 1304-1315. doi: 10.1002/acr.22585
  • 6. Pascual E, Addadi L, Andrés M, Sivera F. Mechanisms of crystal formation in gout—a structural approach. Nature Reviews Rheumatology 2015; 11 (12): 725-730. doi: 10.1038/ nrrheum.2015.125
  • 7. Dalbeth N, Kalluru R, Aati O, Horne A, Doyle AJ et al. Tendon involvement in the feet of patients with gout: a dual-energy CT study. Annals of the Rheumatic Diseases 2013; 72 (9): 1545- 1548. doi: 10.1136/annrheumdis-2012-202786
  • 8. Dalbeth N, Deacon M, Gamble GD, Mithraratne K, Fernandez J. Relationship between tissue stress during gait in healthy volunteers and patterns of urate deposition and bone erosion in gout: a biomechanical computational modelling study. RMD Open 2015; 1 (1): e000101. doi: 10.1136/rmdopen-2015-000101
  • 9. Feig DI, Kang DH, Johnson RJ. Uric acid and cardiovascular risk. New England Journal of Medicine 2008; 359 (17): 1811- 1821. doi: 10.1056/NEJMra0800885
  • 10. Ames PR, Longo UG, Denaro V, Maffulli N. Achilles tendon problems: not just an orthopaedic issue. Disability and Rehabilitation 2008; 30 (20-22): 1646-1650. doi: 10.1080/09638280701785882
  • 11. Jansen TL. Rheumatology meets radiology in the hot soup of Gutta. Arthritis Research & Therapy 2012; 14 (6): 126. doi: 10.1186/ar4068
  • 12. Sebes JI. The significance of calcaneal spurs in rheumatic diseases. Arthritis and Rheumatism 1989; 32 (3): 338-340. doi: 10.1002/anr.1780320316
  • 13. Toumi H, Davies R, Mazor M, Coursier R, Best TM et al. Changes in prevalence of calcaneal spurs in men & women: a random population from a trauma clinic. BMC Musculoskeletal Disorders 2014; 15 (1): 87. doi: 10.1186/1471-2474-15-87
  • 14. Menz HB, Thomas MJ, Marshall M, Rathod-Mistry T, Hall A et al. Coexistence of plantar calcaneal spurs and plantar fascial thickening in individuals with plantar heel pain. Rheumatology (Oxford) 2019; 58 (2): 237-245. doi: 10.1093/rheumatology/ key266
  • 15. Dalbeth N, Milligan A, Doyle AJ, Clark B, McQueen FM. Characterization of new bone formation in gout: a quantitative site-by-site analysis using plain radiography and computed tomography. Arthritis Research & Therapy 2012; 14 (4): R165. doi: 10.1186/ar3913
  • 16. Menz HB, Zammit GV, Landorf KB, Munteanu SE. Plantar calcaneal spurs in older people: longitudinal traction or vertical compression? Journal of Foot and Ankle Research 2008; 1 (1): 7. doi: 10.1186/1757-1146-1-7
  • 17. Beytemur O, Oncu M. The age dependent change in the incidence of calcaneal spur. Acta Orthopaedica et Traumatologica Turcica 2018; 52 (5): 367-371. doi: 10.1016/j. aott.2018.06.013
  • 18. Bassiouni M. Incidence of calcaneal spurs in osteo-arthrosis and rheumatoid arthritis, and in control patients. Annals of the Rheumatic Diseases 1965; 24 (5): 490-493. doi: 10.1136/ ard.24.5.490
  • 19. Gladman DD, Abufayyah M, Salonen D, Thavaneswaran A, Chandran V. Radiological characteristics of the calcaneal spurs in psoriatic arthritis. Clinical and Experimental Rheumatology 2014; 32 (3): 401-403.
  • 20. Barthelemy CR, Nakayama DA, Carrera GF, Lightfoot RW Jr, Wortmann RL. Gouty arthritis: a prospective radiographic evaluation of sixty patients. Skeletal Radiology 1984; 11 (1): 1-8. doi: 10.1007/BF00361124
  • 21. Grayson PC, Kim SY, LaValley M, Choi HK. Hyperuricemia and incident hypertension: a systematic review and metaanalysis. Arthritis Care & Research 2011; 63 (1): 102-110. doi: 10.1002/acr.20344
  • 22. Li L, Yang C, Zhao Y, Zeng X, Liu F et al. Is hyperuricemia an independent risk factor for new-onset chronic kidney disease?: a systematic review and meta-analysis based on observational cohort studies. BMC Nephrology 2014; 15 (1): 122. doi: 10.1186/1471-2369-15-122
  • 23. Lv Q, Meng XF, He FF, Chen S, Su H et al. High serum uric acid and increased risk of type 2 diabetes: a systemic review and meta-analysis of prospective cohort studies. PloS One 2013; 8 (2): p. e56864. doi: 10.1371/journal.pone.0056864
  • 24. Yu TY, Jee JH, Bae JC, Jin SM, Baek JH et al. Serum uric acid: a strong and independent predictor of metabolic syndrome after adjusting for body composition. Metabolism: Clinical and Experimental 2016; 65 (4): 432-440. doi: 10.1016/j. metabol.2015.11.003
  • 25. Moroney PJ, O’Neill BJ, Khan-Bhambro K, O’Flanagan SJ, Keogh P et al. The conundrum of calcaneal spurs: do they matter? Foot & Ankle Specialist 2014; 7 (2): 95-101. doi: 10.1177/1938640013516792
  • 26. Mader R, Sarzi-Puttini P, Atzeni F, Olivieri I, Pappone N et al. Extraspinal manifestations of diffuse idiopathic skeletal hyperostosis. Rheumatology (Oxford) 2009; 48 (12): 1478- 1481. doi: 10.1093/rheumatology/kep308
Turkish Journal of Medical Sciences-Cover
  • ISSN: 1300-0144
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK
Sayıdaki Diğer Makaleler

Can treating critically-ill haematological malignancy patients in a separate intensive care unit decrease intensive care unit mortality?

Zübeyde Nur ÖZKURT, Zeynep Arzu YEGİN, Melda TÜRKOĞLU, Nazlıhan BOYACI DÜNDAR, Gülbin AYGENCEL, Abdullah Münci YAĞCI

Effectiveness of mepolizumab therapy on symptoms, asthma exacerbations, steroid dependence, and small airways in patients with severe eosinophilic asthma

Nuri TUTAR, İnsu YILMAZ, Sakine NAZİK BAHÇECİOĞLU, Murat TÜRK, Gülden PAÇACI ÇETİN, Bahar ARSLAN

The use of high-flow nasal oxygen vs. standard oxygen therapy in hematological malignancy patients with acute respiratory failure in hematology wards

Leylagül KAYNAR, Recep Civan YÜKSEL, Kürşat GÜNDOĞAN, Şahin TEMEL, Murat SUNGUR, Bülent ESER, Nilgün APLTEKİNOĞLU MENDİL

COVID-19 clinical course and blood groups: Turkish population-based study

Semih BAŞCI, Serdal KORKMAZ, Burhan TURGUT, Mehmet Hilmi DOĞU, Fevzi ALTUNTAŞ, Sinem NAMDAROĞLU, Mehmet Sinan DAL, Mehmet Ali ERKURT, Tuğçe Nur YİĞENOĞLU, Şuayip BİRİNCİ, Kürşat DAL, İlhami BERBER, Murat ÇAĞLAYAN, Naim ATA, Abdülkadir BAŞTÜRK, Tuba HACIBEKİROĞLU, Ersan İMRAT, Osman ÇELİK, Mustafa Ma

The relationship between amount of extra-prostatic extension and length of capsular contact: performances from MR images and radical prostatectomy specimens

Barış BAKIR, Aslıhan ONAY

Investigation of the effects of propofol/ketamine versus propofol/fentanyl on nauseavomiting administered for sedation in children undergoing magnetic resonance imaging: a prospective randomized double-blinded study

Ayşe ÜLGEY, Hacı Semih GÜRCAN, Özlem ÖZ GERGİN, Sibel SEÇKİN PEHLİVAN, Karamehmet YILDIZ

The relationship of serum visfatin levels with clinical parameters, flow-mediated dilation, and carotid intima-media thickness in patients with ankylosing spondylitis

Rabia AYDOĞAN BAYKARA, Ahmet OMMA, Erkan CÜRE, Ali Uğur USLU, Göksel TUZCU, Adem KÜÇÜK, Ayça TUZCU

Utilization of biotechnological drugs in rare diseases requiring the use of off-label drugs in children in Turkey

Ahmet AKICI, Volkan AYDIN, Narin AKICI, N. İpek KIRMIZI, Banu BAYAR

Folfirinox versus gemcitabine-cisplatin combination as first-line therapy in treatment of pancreaticobiliary cancer

Ahmet ÖZET, Dilek YAPAR, Hasan SATIŞ, Neslihan KAYAHAN, Mustafa KARACA

The study of Tau and phospho Tau protein levels in attention deficit and hyperactivity disorder

Esra DEMİRCİ, Eser KILIÇ, Hatice SARAÇOĞLU