Sadık ARDIÇ, Cem SAKA, Nurdan AYGENER YEŞİLYURT, Burcu OKTAY ARSLAN, Nevreste Didem SONBAY YILMAZ, Dilek SAKA, İstemihan AKIN

The effect of hypoxia on hearing function

Background/aim: This study was conducted to determine the critical partial oxygen pressure (pO2) value that would impair hearingfunction by evaluating the effects of hypoxia on hearing function in subjects diagnosed with chronic obstructive pulmonary disease(CPOD).Materials and methods: The study included 25 male and 5 female patients referred to our clinic who were diagnosed with COPD,according to spirometry and PaO2 values, and who did not show pathology upon autoscopic examination. The control group consistedof 14 female and 16 male patients who had no lung disease and were in the same age range as the COPD group.Results: A statistically significant difference was found between the two groups for distortion-product otoacoustic emission (DPOAE)(P < 0.001). The COPD group was divided into two groups according to pO2 levels (pO2 ≤ 70 and pO2 > 70) in order to find a critical pO2level which might cause significant change at a certain audiological extent.Conclusion: Hypoxia causes long-term decline in hearing thresholds, deterioration of DPOAE results, and prolongation of I–V interpeaklatency in auditory brainstem response. However, the critical oxygen level that disrupts hearing function could not be determined.

PDF

___

1. Vestbo J, Hurd SS, Agusti AG, Jones PW, Vogelmeier C et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine 2013; 187 (4): 347-369. doi: 10.1164/rccm.201204-0596PP
2. Hogg JC, Chu F, Utokaparch S, Woods R, Elliott WM et al. The nature of small-airway obstruction in chronic obstructive lung disease. The New England Journal of Medicine 2004; 350 (26): 2645-2653. doi: 10.1056/NEJMoa032158
3. El-Kady MA, Durrant JD, Tawfik S, Abdel-Ghany S, Moussa AM. Study of auditory function in patients with chronic obstructive pulmonary diseases. Hearing Research 2006; 21 (1- 2): 109-116. doi: 10.1016/j.heares.2005.05.018
4. Martin DS, Grocott MP. Oxygen therapy in critical illness: precise control of arterial oxygenation and permissive hypoxemia. Critical Care Medicine 2013; 41 (2): 423- 432. doi: 10.1097/CCM.0b013e31826a44f6
5. Olzowy B, Gleichenstein G, Canis M, Plesnila N, Mees K. Complex level alterations of the 2f1-f2 distortion product due to hypoxia in the guinea pig. European Archives of Oto-RhinoLaryngology 2008; 265 (11): 1329-1333. doi: 10.1007/s00405- 008-0663-3
6. Mazurek B, Haupt H, Georgiewa P, Klapp BF, Reisshauer A. A model of peripherally developing hearing loss and tinnitus based on the role of hypoxia and ischemia. Medical Hypotheses 2006; 67 (4): 892-899. doi: 10.1016/j.mehy.2006.03.040
7. Casale M, Vesperini E, Potena M, Pappacena M, Bressi F et al. Is obstructive sleep apnea syndrome a risk factor for auditory pathway? Sleep and Breathing 2012; 16 (2): 413-417. doi: 10.1007/s11325-011-0517-x
8. Hendricks-Munoz KD, Walton JP. Hearing loss in infants with persistent fetal circulation. Pediatrics 1988; 81: 650-656.
9. Hansen S. Postural hypotension–cochleovestibular hypoxia– deafness. Acta Otolaryngological, Supplementum 1988; 449: 165-169.
10. Morawski K, Telischi FF, Merchant F, Abiy LW, Lisowska G et al. Role of mannitol in reducing postischemic changes in distortion-product otoacoustic emissions (DPOAEs): a rabbit model. The Laryngoscope 2003; 113 (9): 1615-1622. doi: 10.1097/00005537-200309000-00039
11. Koga K, Hakuba N, Watanabe F, Shudou M, Nakagawa T et al. Transient cochlear ischemia causes delayed cell death in the organ of Corti: an experimental study in gerbils. The Journal of Comparative Neurology 2003; 456 (2): 105-111. doi: 10.1002/ cne.10479
12. Leite JN, Silva VS, Buzo BC. Otoacoustic emissions in newborns with mild and moderate perinatal hypoxia. Codas 2016 Apr; 28 (2): 93-98. doi: 10.1590/2317-1782/20162015086
13. Telischi FF, Roth J, Stagner BB, Lonsbury-Martin BL, Balkany TJ. Patterns of evoked otoacoustic emissions associated with acoustic neuromas. The Laryngoscope 1995; 105: 675-682. doi: 10.1288/00005537-199507000-00002
14. Carlile S, Paterson DJ. The effects of chronic hypoxia on human auditory system sensitivity. Aviation, Space, and Environmental Medicine 992; 63 (12): 1093-1097.
15. Brown DJ, Hartsock JJ, Gill RM, Fitzgerald HE, Salt AN. Estimating the operating point of the cochlear transducer using low-frequency biased distortion products. The Journal of the Acoustical Society of America 2009 Apr; 125 (4): 2129- 2145. doi: 10.1121/1.3083228
16. Morawski K, Telischi FF, Merchant F, Namyslowski G, Lisowska G et al. Preventing internal auditory artery vasospasm using topical papaverine: an animal study. Otology & Neurotology 2003 Nov; 24 (6): 918-926.
17. Kisser U, Becker S, Feddersen B, Fischer R, Fesl G et al. Complex level alterations of the 2f(1)-f(2) distortion product due to hypoxia. Auris Nasus Larynx 2014; 41 (1): 37-40. doi: 10.1016/j.anl.2013.07.009
18. Urbani L, Lucertini M. Effects of hypobaric hypoxia on the human auditory brainstem responses. Hearing Research 1994; 76(1-2): 73-77.