Havva SEZER, Mehmet Onur DEMİRKOL, Dilek YAZICI, Yersu KAPRAN, Mahmut Faruk ALAGÖL

The clinicopathologic characteristics of familial and sporadic papillary thyroid carcinoma in Turkish patients

Background/aim: The aim of this study is to investigate clinicopathologic features of familial papillary thyroid carcinoma fPTC and compare them with sporadic papillary thyroid carcinoma sPTC in Turkish patients. A retrospective analysis of the papillary thyroid carcinoma PTC cases, with or without family history with a follow-up around 10 years was performed. Materials and methods: A series of patients with fPTC 82 fPTC families with 146 affected individuals were compared with patients with sPTC n = 112 . The clinicopathologic features [ age, gender, histologic subtype, tumour size, bilaterality, multifocality, extrathyroidal extension ETE , lymph node metastasis LNM ] and treatment procedures lymph node dissection, radioactive iodine ablation , and the outcomes like recurrences in the neck region, distant metastasis, and the need for reoperation were compared between the groups. Results: When the groups were compared, there was no significant difference in age P = 0.449 , and tumour size P = 0.898 between familial and sporadic PTC patients. fPTC group had a significantly higher risk of male gender P=0.001 , bilaterality P = 0.004 , multifocality P = 0.011 , LNM P = 0.013 , ETE P = 0.040 , and distant metastasis P ≤ 0.0001 than the sPTC group. However, recurrence rate was similar between the 2 groups P = 0.436 . Conclusion: The results of this study confirms a more aggressive nature in fPTC patients, in terms of bilaterality, multifocality, ETE, LNM, and distant metastasis, compared to sPTC patients in Turkish population.

Keywords:

Familial, sporadic, papillary thyroid cancer,

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