Mustafa Azmi EYİOL, Çağri YAYLA, Serkan ÜNLÜ, Abdurrahman TUFAN, Mustafa CEMRİ, Mehmet Ridvan YALÇIN, Nuri Bülent BOYACI

Relationship of serum HLA-B alleles and TNF-? with rheumatic heart disease

Öz Background/aim: Acute rheumatic fever and rheumatic heart disease are major causes of morbidity and mortality in developing countries. Genetic studies have determined that the immune response in rheumatic heart disease is genetically controlled and that there is a close relationship between the gene of concern and the class II human leukocyte antigen (HLA) gene. The aim of this study was to evaluate the relationship of serum HLA-B alleles and tumor necrosis factor alpha (TNF-∝) with rheumatic heart disease. Materials and methods: A total of 50 consecutive patients with rheumatic heart disease and 50 controls were enrolled in the study. HLA alleles were analyzed using sequence-specific primer-polymerase chain reaction and nucleotide sequencing. Results: The HLA-B35 allele was significantly more common in patients with rheumatic heart disease than the control group (P = 0.043). The HLA-B44 allele was significantly more common in control patients than in patients with rheumatic heart disease (P = 0.014). There was a significant inverse correlation between high-sensitivity C-reactive protein and mitral valve area (P = 0.001). There was no correlation between TNF-∝ levels and mitral valve area (P = 0.066). Conclusion: Our findings confirmed the association between HLA-B alleles and rheumatic heart disease.

Anahtar Kelimeler:

Rheumatic heart disease, human leukocyte antigen B subgroups, tumor necrosis factor alpha

Tam Metin

Kaynak Göster

Bibtex	`@ { tbtkmedical576715, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2018}, volume = {48}, pages = {724 - 729}, doi = {}, title = {Relationship of serum HLA-B alleles and TNF-? with rheumatic heart disease}, key = {cite}, author = {Eyiol, Mustafa Azmi and Yayla, Çağri and Ünlü, Serkan and Tufan, Abdurrahman and Cemri, Mustafa and Yalçın, Mehmet Ridvan and Boyacı, Nuri Bülent} }`
APA	Eyiol, M , Yayla, Ç , Ünlü, S , Tufan, A , Cemri, M , Yalçın, M , Boyacı, N . (2018). Relationship of serum HLA-B alleles and TNF-? with rheumatic heart disease . Turkish Journal of Medical Sciences , 48 (4) , 724-729 . Retrieved from https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45702/576715
MLA	Eyiol, M , Yayla, Ç , Ünlü, S , Tufan, A , Cemri, M , Yalçın, M , Boyacı, N . "Relationship of serum HLA-B alleles and TNF-? with rheumatic heart disease" . Turkish Journal of Medical Sciences 48 (2018 ): 724-729 <https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45702/576715>
Chicago	Eyiol, M , Yayla, Ç , Ünlü, S , Tufan, A , Cemri, M , Yalçın, M , Boyacı, N . "Relationship of serum HLA-B alleles and TNF-? with rheumatic heart disease". Turkish Journal of Medical Sciences 48 (2018 ): 724-729
RIS	TY - JOUR T1 - Relationship of serum HLA-B alleles and TNF-? with rheumatic heart disease AU - Mustafa Azmi Eyiol , Çağri Yayla , Serkan Ünlü , Abdurrahman Tufan , Mustafa Cemri , Mehmet Ridvan Yalçın , Nuri Bülent Boyacı Y1 - 2018 PY - 2018 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 724 EP - 729 VL - 48 IS - 4 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2021 ER -
EndNote	%0 Turkish Journal of Medical Sciences Relationship of serum HLA-B alleles and TNF-? with rheumatic heart disease %A Mustafa Azmi Eyiol , Çağri Yayla , Serkan Ünlü , Abdurrahman Tufan , Mustafa Cemri , Mehmet Ridvan Yalçın , Nuri Bülent Boyacı %T Relationship of serum HLA-B alleles and TNF-? with rheumatic heart disease %D 2018 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 48 %N 4 %R %U
ISNAD	Eyiol, Mustafa Azmi , Yayla, Çağri , Ünlü, Serkan , Tufan, Abdurrahman , Cemri, Mustafa , Yalçın, Mehmet Ridvan , Boyacı, Nuri Bülent . "Relationship of serum HLA-B alleles and TNF-? with rheumatic heart disease". Turkish Journal of Medical Sciences 48 / 4 (Ağustos 2018): 724-729 .
AMA	Eyiol M , Yayla Ç , Ünlü S , Tufan A , Cemri M , Yalçın M , Boyacı N . Relationship of serum HLA-B alleles and TNF-? with rheumatic heart disease. Turkish Journal of Medical Sciences. 2018; 48(4): 724-729.
Vancouver	Eyiol M , Yayla Ç , Ünlü S , Tufan A , Cemri M , Yalçın M , Boyacı N . Relationship of serum HLA-B alleles and TNF-? with rheumatic heart disease. Turkish Journal of Medical Sciences. 2018; 48(4): 724-729.
IEEE	M. Eyiol , Ç. Yayla , S. Ünlü , A. Tufan , M. Cemri , M. Yalçın ve N. Boyacı , "Relationship of serum HLA-B alleles and TNF-? with rheumatic heart disease", Turkish Journal of Medical Sciences, c. 48, sayı. 4, ss. 724-729, Ağu. 2018