Umut Ziya KOÇAK, Bayram ÜNVER, Abdurrahman NALBANT, Ertuğrul YÜKSEL, Buse ÖZCAN KAHRAMAN

Reference values and prediction equation for the 6-minute walk test in healthy children aged 6–12 years old

Background/aim: The 6-minute walk test (6MWT) is the most commonly used and well-established test to measure functional exercisecapacity in research and clinical settings. Country-specific reference values are important to interpret the results of 6MWT. However, noreference values have been reported for healthy Turkish children aged between 6 and 12 years old. The aim of this study was to determinenormal reference values for the 6MWT test of healthy Turkish children aged between 6 and 12 years old.Materials and methods: Two hundred and sixty-two healthy children aged between 6 and 12 years old were included in this crosssectional study. Measures included height, weight, body mass index (BMI), leg length, and 6MWT distance (6MWD).Results: The mean 6MWD was 572.58 (SD = 117.72) m. There were significant correlations between 6MWD and age (r = 0.764, P

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1. Mezzani A, Hamm LF, Jones AM, McBride PE, Moholdt T et al. Aerobic exercise intensity assessment and prescription in cardiac rehabilitation: a joint position statement of the European Association for Cardiovascular Prevention and Rehabilitation, the American Association of Cardiovascular and Pulmonary Rehabilitation and the Canadian Association of Cardiac Rehabilitation. European Journal of Preventive Cardiology 2013; 20 (3): 442-467. doi: 10.1177/2047487312460484
2. Noonan V, Dean E. Submaximal exercise testing: clinical application and interpretation. Physical Therapy 2000; 80 (8): 782-807. doi:10.1093/ptj/80.8.782
3. Kendrick KR, Baxi SC, Smith RM. Usefulness of the modified 0–10 Borg scale in assessing the degree of dyspnea in patients with COPD and asthma. Journal of Emergency Nursing 2000; 26 (3): 216-222. doi:10.1067/men.2000.107012
4. Solway S, Brooks D, Lacasse Y, Thomas S. A qualitative systematic overview of the measurement properties of functional walk tests used in the cardiorespiratory domain. Chest 2001; 119 (1): 256-270. doi: 10.1378/chest.119.1.256
5. Enright PL. The six-minute walk test. Respiratory Care 2003; 48 (8): 783-785.
6. Rasekaba T, Lee AL, Naughton MT, Williams TJ, Holland AE. The six-minute walk test: a useful metric for the cardiopulmonary patient. Internal Medicine Journal 2009; 39 (8): 495-501. doi: 10.1111/j.1445-5994.2008.01880.x
7. Brown CD, Wise RA. Field tests of exercise in COPD: the sixminute walk test and the shuttle walk test. COPD 2007; 4 (3): 217-223. doi: 10.1080/15412550701480125
8. Ulrich S, Hildenbrand FF, Treder U, Fischler M, Keusch S et al. Reference values for the 6-minute walk test in healthy children and adolescents in Switzerland. BMC Pulmonary Medicine 2013; 13: 49. doi: 10.1186/1471-2466-13-49
9. D’Silva C, Vaishali K, Venkatesan P. Six-minute walk test— normal values of school children aged 7–12 y in India: a crosssectional study. The Indian Journal of Pediatrics 2012; 79 (5): 597-601. doi: 10.1007/s12098-011-0559-x
10. Li AM, Yin J, Au JT, So HK, Tsang T et al. Standard reference for the six-minute-walk test in healthy children aged 7 to 16 years. American Journal of Respiratory and Critical Care Medicine 2007; 176 (2): 174-180. doi: 10.1164/rccm.200607-883OC
11. Geiger R, Strasak A, Treml B, Gasser K, Kleinsasser A et al. Six-minute walk test in children and adolescents. The Journal of Pediatrics 2007; 150 (4): 395-399e-2. doi: 10.1016/j. jpeds.2006.12.052
12. Lammers AE, Hislop AA, Flynn Y, Haworth SG. The 6-minute walk test: normal values for children of 4–11 years of age. Archives of Disease in Childhood 2008; 93 (6): 464-468. doi: 10.1136/adc.2007.123653
13. Priesnitz CV, Rodrigues GH, Stumpf Cda S, Viapiana G, Cabral CP et al. Reference values for the 6-min walk test in healthy children aged 6–12 years. Pediatric Pulmonology 2009; 44 (12): 1174-1179. doi: 10.1002/ppul.21062
14. Ben Saad H, Prefaut C, Missaoui R, Mohamed IH, Tabka Z et al. Reference equation for 6-min walk distance in healthy North African children 6–16 years old. Pediatric Pulmonology 2009; 44 (4): 316-324. doi: 10.1002/ppul.20942
15. Limsuwan A, Wongwandee R, Khowsathit P. Correlation between 6-min walk test and exercise stress test in healthy children. Acta Paediatrica 2010; 99 (3): 438-441. doi: 10.1111/j.1651-2227.2009.01602.x
16. Klepper SE, Muir N. Reference values on the 6-minute walk test for children living in the United States. Pediatric Physical Therapy 2011; 23 (1): 32-40. doi: 10.1097/ PEP.0b013e3182095e44
17. Li AM, Yin J, Yu CC, Tsang T, So HK et al. The six-minute walk test in healthy children: reliability and validity. European Respiratory Journal 2005; 25 (6): 1057-1060. doi: 10.1183/09031936.05.00134904
18. Mylius CF, Paap D, Takken T. Reference value for the 6-minute walk test in children and adolescents: a systematic review. Expert Review of Respiratory Medicine 2016; 10 (12): 1335- 1352. doi: 10.1080/17476348.2016.1258305
19. Cacau LA, De Santana-Filho VJ, Maynard LG, Gomes MN, Fernandes M et al. Reference values for the six-minute walk test in healthy children and adolescents: a systematic review. Brazilian Journal of Cardiovascular Surgery 2016; 31 (5): 381- 388. doi: 10.5935/1678-9741.20160081
20. Rodriguez-Nunez I, Mondaca F, Casas B, Ferreira C, Zenteno D. Normal values of 6-minute walk test in healthy children and adolescents: a systematic review and meta-analysis. Revista Chilena de Pediatría. 2018; 89 (1): 128-136. doi: 10.4067/ S0370-41062018000100128 (article in Spanish with an abstract in English).
21. Kanburoglu MK, Ozdemir FM, Ozkan S, Tunaoglu FS. Reference values of the 6-minute walk test in healthy Turkish children and adolescents between 11 and 18 years of age. Respiratory Care 2014; 59 (9): 1369-1375. doi: 10.4187/ respcare.02891
22. ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. ATS statement: guidelines for the six-minute walk test. American Journal of Respiratory and Critical Care Medicine 2002; 166 (1): 111-117. doi: 10.1164/ajrccm.166.1.at1102
23. Cohen J. Statistical power analysis for the behavioural sciences. 2nd ed. Hillsdale, NJ, USA: Lawrence Erlbaum Associates; 1988.
24. Pandis N. Linear regression. American Journal of Orthodontics and Dentofacial Orthopedics 2016; 149 (3): 431-434. doi: 10.1016/j.ajodo.2015.11.019
25. Goemans N, Klingels K, Van den Hauwe M, Boons S, Verstraete L et al. Six-minute walk test: reference values and prediction equation in healthy boys aged 5 to 12 years. PLoS One. 2013; 8 (12): e84120. doi: 10.1371/journal.pone.0084120
26. Goemans N, Klingels K, Van den Hauwe M, Van Orshoven A, Vanpraet S et al. Test-retest reliability and developmental evolution of the 6-min walk test in Caucasian boys aged 5–12 years. Neuromuscular Disorders 2013; 23 (1): 19-24. doi: 10.1016/j.nmd.2012.10.019
27. Bundak R, Furman A, Gunoz H, Darendeliler F, Bas F et al. Body mass index references for Turkish children. Acta Paediatrica 2006; 95 (2): 194-198. doi: 10.1080/08035250500334738