Prevalence and risk factors for vitamin D deficiency in patients with widespread musculoskeletal pain
Prevalence and risk factors for vitamin D deficiency in patients with widespread musculoskeletal pain
Background/aim: The aim of this study was to examine the prevalence of 25-hydroxyvitamin D (25(OH) vitamin D) deficiency in patients complaining of widespread musculoskeletal pain. Materials and methods: In this cross-sectional study, 14,925 patients (13,589 females and 1336 males; mean age: 47.0 years, range: 20 99 years) were included. Serum 25(OH) vitamin D was measured by ELISA. The patients were classified into two groups: 1) patients with vitamin D deficiency (20 ng/mL). Results: The prevalence of vitamin D deficiency was 73.9%. A multivariate logistic regression model showed that low 25(OH) vitamin D level was associated with sex, age, and month in which 25(OH) hypovitaminosis was determined. The risk of a low 25(OH) vitamin D was level was 1.74 times higher in female patients than in males. The risk of low 25(OH) vitamin D level was highest in March during the year. Conclusion: Our results indicate that vitamin D deficiency should be considered in patients with widespread musculoskeletal pain and some precautions, such as sunbathing during summer, should be recommended for patients with a risk of vitamin D deficiency
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- 1. Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 2004; 80: 1678-1688.
- 2. Holick MF. Resurrection of vitamin D deficiency and rickets. J Clin Invest 2006; 116: 2062-2072.
- 3. Sözen T, Sözen T, Gogas Yavuz D, Almaca A, Hekimsoy Z, Altun B, Cantürk Z, Tanakol R, Kaya A, Akalın A et al. Metabolic Bone Disease Diagnosis and Treatment Guidelines. 1st ed. İstanbul, Turkey: Galenos; 2014 (in Turkish).
- 4. Freund RJ, Wilson WJ, Sa P. Regression Analysis Statistical Modeling of a Response Variable. 2nd ed. New York, NY, USA: Elsevier; 2006.
- 5. Kolthoff N, Gram J, Hermann AP, Sorensen OH .Vitamin D status and its adequacy in healthy Danish perimenopausal women: relationships to dietary intake, sun exposure and serum parathyroid hormone. Br J Nutr 2001; 86: S97-103.
- 6. Hill TR, McCarthy D, Jakobsen J, Lamberg-Allardt C, Kiely M, Cashman KD. Seasonal changes in vitamin D status and bone turnover in healthy Irish postmenopausal women. Int J Vitam Nutr Res 2007; 77: 320-325.
- 7. Valtueña J, González-Gross M, Huybrechts I, Breidenassel C, Ferrari M, Mouratidou T, Gottrand F, Dallongeville J, Azzini E, Sioen I et al. Factors associated with vitamin D deficiency in European adolescents. The HELENA Study. J Nutr Sci Vitaminol (Tokyo) 2013; 59: 161-171.
- 8. Heidari B, Haji Mirghassemi MB. Seasonal variations in serum vitamin D according to age and sex. Caspian J Intern Med 2012; 3: 535-540.
- 9. Hovsepian S, Amini M, Aminorroaya A, Amini P, Iraj B. Prevalence of vitamin D deficiency among adult population of Isfahan City, Iran. J Health Popul Nutr 2011; 29: 149-155.