Maryam MOHAMMADBEIGI, Zahra Safayi DELOUYI, Nima MOHAMMADZADEH, Arash ALA'ALMOHADESIN, Keyvan TAHERI, Elahe EDALATI, Mansour SEDIGHI, Abed Zahedi BIALVAEI

Prevalence and antimicrobial susceptibility pattern of toxigenic Clostridium difficilestrains isolated in Iran

Öz Background/aim: Clostridium difficile is a frequent cause of nosocomial infections and has become a major public health concern in developed nations. In the present study, the prevalence and antimicrobial susceptibility pattern of toxigenic C. difficile strains isolated in Iran were investigated.Materials and methods: Between June 2016 and May 2017, 2947 inpatient fecal samples were taken from symptomatic adult hospitalized patients in different units of 32 care facilities in Tehran, Iran. C. difficile strains were identified by microbiological/biochemical methods. Susceptibility to 20 antimicrobials was measured by E-test method. Toxin-specific immunoassays and cytotoxicity assays were used to determine in vitro toxin production.Results: Out of 2947 fecal samples, 538 (18.25%) C. difficile isolates were obtained among those with suspected CDI. In E-test method, all C. difficile isolates were susceptible to fidaxomicin, vancomycin, amoxicillin/clavulanate, and meropenem and were resistant to penicillin G. The prevalence of multidrug resistant C. difficile was 69.33% (373/538). Among 538 C. difficile, 147 (27.32%), 169 (31.41%), and 222 (41.26%) isolates were TcdA+/TcdB+, TcdA-/TcdB+, and TcdA-/TcdB-, respectively.Conclusion: The results evidently support the hypothesis of a probable role of toxigenic strains of C. difficile in developing gastrointestinal complaints in patients with diarrhea.

Anahtar Kelimeler:

Clostridium difficile, prevalence, toxin A, toxin B, antimicrobial resistance, Iran

Tam Metin

Kaynak Göster

Bibtex	@ { tbtkmedical577832, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2019}, volume = {49}, pages = {384 - 391}, doi = {}, title = {Prevalence and antimicrobial susceptibility pattern of toxigenic Clostridium difficilestrains isolated in Iran}, key = {cite}, author = {Mohammadbeıgı, Maryam and Delouyı, Zahra Safayi and Mohammadzadeh, Nima and Ala\&\#039;almohadesın, Arash and Taherı, Keyvan and Edalatı, Elahe and Sedıghı, Mansour and Bıalvaeı, Abed Zahedi} }
APA	Mohammadbeıgı, M , Delouyı, Z , Mohammadzadeh, N , Ala'almohadesın, A , Taherı, K , Edalatı, E , Sedıghı, M , Bıalvaeı, A . (2019). Prevalence and antimicrobial susceptibility pattern of toxigenic Clostridium difficilestrains isolated in Iran . Turkish Journal of Medical Sciences , 49 (1) , 384-391 . Retrieved from https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45750/577832
MLA	Mohammadbeıgı, M , Delouyı, Z , Mohammadzadeh, N , Ala'almohadesın, A , Taherı, K , Edalatı, E , Sedıghı, M , Bıalvaeı, A . "Prevalence and antimicrobial susceptibility pattern of toxigenic Clostridium difficilestrains isolated in Iran" . Turkish Journal of Medical Sciences 49 (2019 ): 384-391 <https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45750/577832>
Chicago	Mohammadbeıgı, M , Delouyı, Z , Mohammadzadeh, N , Ala'almohadesın, A , Taherı, K , Edalatı, E , Sedıghı, M , Bıalvaeı, A . "Prevalence and antimicrobial susceptibility pattern of toxigenic Clostridium difficilestrains isolated in Iran". Turkish Journal of Medical Sciences 49 (2019 ): 384-391
RIS	TY - JOUR T1 - Prevalence and antimicrobial susceptibility pattern of toxigenic Clostridium difficilestrains isolated in Iran AU - Maryam Mohammadbeıgı , Zahra Safayi Delouyı , Nima Mohammadzadeh , Arash Ala'almohadesın , Keyvan Taherı , Elahe Edalatı , Mansour Sedıghı , Abed Zahedi Bıalvaeı Y1 - 2019 PY - 2019 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 384 EP - 391 VL - 49 IS - 1 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2021 ER -
EndNote	%0 Turkish Journal of Medical Sciences Prevalence and antimicrobial susceptibility pattern of toxigenic Clostridium difficilestrains isolated in Iran %A Maryam Mohammadbeıgı , Zahra Safayi Delouyı , Nima Mohammadzadeh , Arash Ala'almohadesın , Keyvan Taherı , Elahe Edalatı , Mansour Sedıghı , Abed Zahedi Bıalvaeı %T Prevalence and antimicrobial susceptibility pattern of toxigenic Clostridium difficilestrains isolated in Iran %D 2019 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 49 %N 1 %R %U
ISNAD	Mohammadbeıgı, Maryam , Delouyı, Zahra Safayi , Mohammadzadeh, Nima , Ala'almohadesın, Arash , Taherı, Keyvan , Edalatı, Elahe , Sedıghı, Mansour , Bıalvaeı, Abed Zahedi . "Prevalence and antimicrobial susceptibility pattern of toxigenic Clostridium difficilestrains isolated in Iran". Turkish Journal of Medical Sciences 49 / 1 (Şubat 2019): 384-391 .
AMA	Mohammadbeıgı M , Delouyı Z , Mohammadzadeh N , Ala'almohadesın A , Taherı K , Edalatı E , Sedıghı M , Bıalvaeı A . Prevalence and antimicrobial susceptibility pattern of toxigenic Clostridium difficilestrains isolated in Iran. Turkish Journal of Medical Sciences. 2019; 49(1): 384-391.
Vancouver	Mohammadbeıgı M , Delouyı Z , Mohammadzadeh N , Ala'almohadesın A , Taherı K , Edalatı E , Sedıghı M , Bıalvaeı A . Prevalence and antimicrobial susceptibility pattern of toxigenic Clostridium difficilestrains isolated in Iran. Turkish Journal of Medical Sciences. 2019; 49(1): 384-391.
IEEE	M. Mohammadbeıgı , Z. Delouyı , N. Mohammadzadeh , A. Ala'almohadesın , K. Taherı , E. Edalatı , M. Sedıghı ve A. Bıalvaeı , "Prevalence and antimicrobial susceptibility pattern of toxigenic Clostridium difficilestrains isolated in Iran", Turkish Journal of Medical Sciences, c. 49, sayı. 1, ss. 384-391, Şub. 2019