Polymorphisms of cancer-related genes and risk of multipleprimary malignancies involving colorectal cancer

Background/aim: This study aimed to investigate the relationship between single nucleotide polymorphisms (SNPs) of cancer-related genes and the risk of multiple primary malignancies involving colorectal cancer. Materials and methods: We collected tissue samples from 22 multiple primary cancer patients with primary colorectal cancer and performed genotyping assay for 116 SNP loci from 62 genes encoding peptides functioning in various signaling pathways using the DNA MassARRAY system. The chi-square test was used to compare the differences in base frequencies between patients and a control Chinese population from HapMap through the NCBI database. Results: No significant differences in frequencies were detected for 81 SNPs (P > 0.05), while serious frequency differences were observed for 35 SNPs from 31 genes (P < 0.05), which included ERCC6 (rs2228526), ERCC1 (rs3212986), CASP8 (rs3834129, rs3769818), and others presented. Five of these SNPs were previously reported to be associated with the pathogenesis of colorectal cancer. Conclusion: The 35 SNPs from 31 genes may be associated with the risk of multiple primary malignancies involving colorectal cancer

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1. Morton LM, Swerdlow AJ, Schaapveld M, Ramadan S, Hodgson DC, Radford J. Current knowledge and future research directions in treatment-related second primary malignancies. EJC Suppl 2014; 12: 5-17.
2. Morton LM, Onel K, Curtis RE, Hungate EA, Armstrong GT. The rising incidence of second cancers: patterns of occurrence and identification of risk factors for children and adults. J Natl Cancer Inst 2014; 102: 57-67.
3. Ueno M, Muto T, Oya M, Ota H, Azekura K, Yamaguchi T. Multiple primary cancer: an experience at the Cancer Institute Hospital with special reference to colorectal cancer. Int J Clin Oncol 2003; 8: 162-167.
4. Lam AKY, Carmichael R, Buettner PG, Gopalan V, Ho YH, Siu S. Clinicopathological significance of synchronous carcinoma in colorectal cancer. Am J Surg 2011; 202: 39-44.
5. Pajares JA, Perea J. Multiple primary colorectal cancer: Individual or familial predisposition? World J Gastrointest Oncol 2015; 7: 434.
6. Chang CC, Chung YH, Liou CB, Lee YC, Weng WL, Yu YC, Wu JM. Influence of residential environment and lifestyle on multiple primary malignancies in Taiwan. Asian Pac J Cancer P 2015; 16: 3533-3538.
7. Alharithy, Rowyda N. Polymorphisms in RETN gene and susceptibility to colon cancer in Saudi patients. Ann Saudi Med 2014; 34: 334-339.
8. Rafrafi A, Kaabachi S, Kaabachi W, Chahed B, Amor AB, Mbarik M, Sassi FH. CCR2-64I polymorphism is associated with non-small cell lung cancer in Tunisian patients. Hum Immunol 2015; 76: 348-354.
9. Guo CX, Wang J, Huang LH, Li JG., Chen X. Impact of single-nucleotide polymorphisms on radiation pneumonitis in cancer patients (review). Mol Clin Oncol 2016; 4: 3-10.
10. Warren S, Gates O. Carcinoma of ceruminous gland. Am J Pathol 1941; 17:821-826.
11. Lee TK, Barringer M, Myers RT, Sterchi JM. Multiple primary carcinomas of the colon and associated extracolonic primary malignant tumors. Ann Surg 1982; 195: 501-507.
12. Yu Y, Zheng S, Zhang S, Jin W, Liu H, Jin M, Chen K. Polymorphisms of inflammation-related genes and colorectal cancer risk: a population-based casecontrol study in China. Int J Immunogenet 2014; 41: 289-297.
13. Polakova V, Pardini B, Naccarati A, Landi S, Slyskova J, Novotny J, Tulupova E. Genotype and haplotype analysis of cell cycle genes in sporadic colorectal cancer in the Czech Republic. Hum Mutat 2009; 30: 661-668.
14. Huang CY, Tsai CW, Hsu CM, Chang WS, Shui HA, Bau DT. The significant association of CCND1 genotypes with colorectal cancer in Taiwan. Tumor Biol 2015; 36: 6533-6540.
15. Kopp TI, Andersen V, Tjonneland A, Vogel U. Polymorphisms in NFKB1 and TLR4 and interaction with dietary and life style factors in relation to colorectal cancer in a Danish prospective case-cohort study. PLoS One 2015; 10: e0116394.
16. Hou R, Liu Y, Feng Y, Sun L, Shu Z, Zhao J, Yang S. Association of single nucleotide polymorphisms of ERCC1 and XPF with colorectal cancer risk and interaction with tobacco use. Gene 2014; 548: 1-5.
17. Kobayashi Y, Arimoto H, Watanabe S. Occurrence of multiple primary cancer at the National Cancer Center Hospital, 1962 1989. Jpn J Clin Oncol 1991; 21: 233-251.
18. Lee WS, Lee JN, Choi S, Jung M, Baek JH, Lee WK. Multiple primary malignancies involving colorectal cancerclinical characteristics and prognosis with reference to surveillance. Langenbeck A Rch Surg 2010; 395: 359-364.
19. Xu F, Zhou G, Han S, Yuan W, Chen S, Fu Z, Pang D. Association of TNF-α, TNFRSF1A and TNFRSF1B gene polymorphisms with the risk of sporadic breast cancer in northeast Chinese Han women. PLoS One 2014; 9: e101138.
20. Wang W, Spitz MR, Yang H, Lu C, Stewart DJ, Wu X. Genetic variants in cell cycle control pathway confer susceptibility to lung cancer. Clin Cancer Res 2007; 13: 5974-5981.
21. Chen D, Ma T, Liu XW, Liu, Z. CASP-8-652 6N ins/del polymorphism and cancer risk: a literature-based systematic HuGE review and meta-analysis. Exp Ther Med 2012; 4: 762- 770.
22. Zhou LP, Luan H, Dong XH, Jin GJ, Man DL, Shang H. Association between XRCC5, 6 and 7 gene polymorphisms and the risk of breast cancer: a HuGE review and meta-analysis. Asian Pac J Cancer P 2012; 13: 3637-3643.
23. Jin F, Qian C, Qing Y, Zhang Z, Wang G., Shan J, Wang D. Genetic polymorphism of APE1 rs1130409 can contribute to the risk of lung cancer. Tumor Biol 2014; 35: 6665-6671.
24. Huang JY, Yang JF, Qu Q, Qu J, Liu F, Liu FE, Lu SH. DNA repair gene XRCC3 variants are associated with susceptibility to glioma in a Chinese population. Genet Mol Res 2015; 14: 10569.
25. Wang S, Tian Y, Wu D, Zhu H, Luo D, Gong W, Zhang, Z. Genetic variation of CTNNB1 gene is associated with susceptibility and prognosis of gastric cancer in a Chinese population. Mutagenesis 2012; 27: 623-630.
26. Wang R, Zhang Y, Zhang J, Zhi X. Association of X-ray repair cross-complementing group 1 promoter rs3213245 polymorphism with lung cancer risk. Tumor Biol 2014; 35: 1739-1743.
27. Li B, Liu H, Gong F, Sun P, Yan Y, Jia B. Molecular epidemiologic correlation analysis between caspase3 gene polymorphism and gastric cancer susceptibility. Cell Biochem Biophys 2014; 70: 1647-1653.
28. Zang X, Zhou Y, Huang Z, Zhang C. Endothelin-1 single nucleotide polymorphisms and risk of pulmonary metastatic osteosarcoma. PLoS One 2013; 8: e73349.
29. Zheng L, Tang W, Shi Y, Chen S, Wang X, Wang L, Yin J. p21 rs3176352 G> C and p73 rs1801173 C> T polymorphisms are associated with an increased risk of esophageal cancer in a Chinese population. PLoS One 2014; 9: e96958.
30. Lee SY, Kang HG, Yoo SS, Kang YR, Choi YY, Lee WK, Kim KS. Polymorphisms in DNA repair and apoptosis-related genes and clinical outcomes of patients with non-small cell lung cancer treated with first-line paclitaxel-cisplatin chemotherapy. Lung Cancer 2013; 82: 330-339.
31. Wen J, Liu H, Wang Q, Liu Z, Li Y, Xiong H, Mohan R. Genetic variants of the LIN28B gene predict severe radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy. Eur J Cancer 2014; 50: 1706- 1716.
32. Peng J, Yang LX, Zhao XY, Gao ZQ, Yang J, Wu WT, Jin L. VCP gene variation predicts outcome of advanced non-small-cell lung cancer platinum-based chemotherapy. Tumor Biol 2013; 34: 953-961.
33. Xu Z, Chen Y, Gu D, Lee NP, Sun S, Gong W, Chen J. SOD2 rs4880 CT/CC genotype predicts poor survival for Chinese gastric cancer patients received platinum and fluorouracil based adjuvant chemotherapy. Am J Transl Res 2015; 7: 401.
34. Ferguson LR, Han DY, Huebner C, Petermann I, Barclay ML, Gearry RB, Demmers PS. Tumor necrosis factor receptor superfamily, member 1B haplotypes increase or decrease the risk of inflammatory bowel diseases in a New Zealand Caucasian population. Gastroent Res Pract 2009; 2009: 591704.
35. Varadé J, Palomino-Morales R, Ortego-Centeno N, DíazRubio M, Fernández-Gutiérrez B, González-Gay MÁ, Witte T. Analysis of the REL polymorphism rs13031237 in autoimmune diseases. Ann Rheum Dis 2011;70: 711-712.
36. Namjou B, Choi CB, Harley IT, Alarcón-Riquelme ME, Kelly JA, Glenn SB, Boackle SA. Evaluation of TRAF6 in a large multiancestral lupus cohort. Arthritis Rheumatol 2012; 64: 1960-1969.
37. Kim HJ, Choi CP, Uhm YK, Kim YI, Lee JW, Yoon SH, Lee MH. The association between endothelin-1 gene polymorphisms and susceptibility to vitiligo in a Korean population. Exp Dermatol 2007; 16: 561-566.
38. Ho LT, Hsu YP, Hsiao CF, Ting CT, Shih KC, Chuang LM, Lin MW. Endothelin type A receptor genotype is a determinant of quantitative traits of metabolic syndrome in Asian hypertensive families: a SAPPHIRe study. Front Neuroendocrin 2013; 4: 172.
39. Cai G, Zhang B, Weng W, Shi G, Huang Z. The associations between the MCP-1 2518 A/G polymorphism and ischemic heart disease and ischemic stroke: a meta-analysis of 28 research studies involving 21,524 individuals. Mol Biol Rep 2015; 42: 997-1012.
40. Vialykh EK, Solidolova MA, Bushueva O, Bulgakova IV, Polonikov AV. Catalase gene polymorphism is associated with increased risk of cerebral stroke in hypertensive patients. Zh Nevrol Psikhiatr Im S S Korsakova 2011; 112: 3-7 (in Russian with abstract in English).