Hale Çolakoğlu ER, Gül Ayşe ERDEN

Mean ADC values discriminate rectal mucinous carcinomafrom rectal nonmucinous adenocarcinoma

Öz Background/aim: This study aimed to differentiate rectal mucinous carcinoma (MC) from nonmucinous rectal adenocarcinoma (AC) using mean apparent diffusion coefficient (mADC) values obtained with diffusion-weighted imaging.Materials and methods: Sixty-two pathologically confirmed rectal AC (n = 44) and MC (n = 18) patients were included in this study. The two groups underwent pelvic MRI to determine the local staging baseline for rectal tumors. Once the region of interest (ROI) was determined, a border was drawn around each hyperintense tumor (b = 1000 s/mm2 images). Following a repeat of this procedure for each patient, the ROIs were recorded to apparent diffusion coefficient (ADC) maps, and mADC values were measured. The mADC was determined per slice, followed by a calculation of whole tumor volume ADC mean using the individual mADC values. The Mann?Whitney test was performed to compare mADCs for the two groups. A receiver operating characteristic (ROC) curve was generated to determine the differentiating capacity of ADCs from MC to AC. Results: The mADC was higher in MC (1.631 $\pm$ 0.375 x 10-3 mm2/s) (range: 0.95-2.36 x 10-3 mm2/s) than in AC (0.921 $\pm$ 0.157 x 10-3 mm2/s) (range: 0.6-1.48 x 10-3 mm2/s) (P < 0.001). mADCs were effective in distinguishing MC from AC (area under the ROC curve, 0.972 (95% CI : 0.928-1.00)). A threshold of 1.27 x 10-3 mm2/s was set that corresponded with high sensitivity (94.4%) and specificity (97.7%). Twelve MCs (67%) were predominantly hypointense, and 6 MCs (33%) were seen as mixed signal intensity lesions. Forty ACs (91%) were observed as hyperintense lesions, and 4 ACs (9%) had mixed signal intensity. There was a significant difference in the signal intensities between MC and AC (c2 = 54.7, P < 0.001).Conclusion: MCs and ACs show different diffusion characteristics, which can be distinguished with high sensitivity and specificity and can help to improve prognostic treatment options.

Anahtar Kelimeler:

Rectal cancer, adenocarcinoma, mucinous adenocarcinoma, diffusion-weighted imaging, apparent diffusion coefficient

Tam Metin

Kaynak Göster

Bibtex	`@ { tbtkmedical576383, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2017}, volume = {47}, pages = {1520 - 1525}, doi = {}, title = {Mean ADC values discriminate rectal mucinous carcinomafrom rectal nonmucinous adenocarcinoma}, key = {cite}, author = {Er, Hale Çolakoğlu and Erden, Gül Ayşe} }`
APA	Er, H , Erden, G . (2017). Mean ADC values discriminate rectal mucinous carcinomafrom rectal nonmucinous adenocarcinoma . Turkish Journal of Medical Sciences , 47 (5) , 1520-1525 . Retrieved from https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45689/576383
MLA	Er, H , Erden, G . "Mean ADC values discriminate rectal mucinous carcinomafrom rectal nonmucinous adenocarcinoma" . Turkish Journal of Medical Sciences 47 (2017 ): 1520-1525 <https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45689/576383>
Chicago	Er, H , Erden, G . "Mean ADC values discriminate rectal mucinous carcinomafrom rectal nonmucinous adenocarcinoma". Turkish Journal of Medical Sciences 47 (2017 ): 1520-1525
RIS	TY - JOUR T1 - Mean ADC values discriminate rectal mucinous carcinomafrom rectal nonmucinous adenocarcinoma AU - Hale Çolakoğlu Er , Gül Ayşe Erden Y1 - 2017 PY - 2017 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 1520 EP - 1525 VL - 47 IS - 5 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2021 ER -
EndNote	%0 Turkish Journal of Medical Sciences Mean ADC values discriminate rectal mucinous carcinomafrom rectal nonmucinous adenocarcinoma %A Hale Çolakoğlu Er , Gül Ayşe Erden %T Mean ADC values discriminate rectal mucinous carcinomafrom rectal nonmucinous adenocarcinoma %D 2017 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 47 %N 5 %R %U
ISNAD	Er, Hale Çolakoğlu , Erden, Gül Ayşe . "Mean ADC values discriminate rectal mucinous carcinomafrom rectal nonmucinous adenocarcinoma". Turkish Journal of Medical Sciences 47 / 5 (Ekim 2017): 1520-1525 .
AMA	Er H , Erden G . Mean ADC values discriminate rectal mucinous carcinomafrom rectal nonmucinous adenocarcinoma. Turkish Journal of Medical Sciences. 2017; 47(5): 1520-1525.
Vancouver	Er H , Erden G . Mean ADC values discriminate rectal mucinous carcinomafrom rectal nonmucinous adenocarcinoma. Turkish Journal of Medical Sciences. 2017; 47(5): 1520-1525.
IEEE	H. Er ve G. Erden , "Mean ADC values discriminate rectal mucinous carcinomafrom rectal nonmucinous adenocarcinoma", Turkish Journal of Medical Sciences, c. 47, sayı. 5, ss. 1520-1525, Eki. 2017