Evaluation of hepatocellular carcinoma with computed tomography perfusion imaging

To evaluate the role of computed tomography (CT) perfusion imaging in patients with hepatocellular carcinoma (HCC). Materials and methods: Seventeen patients (9 men, 8 women) with newly diagnosed HCC, proven by biopsy, were evaluated with 256-slice helical CT. Perfusion parameters of blood flow (BF), blood volume (BV), arterial perfusion (AP), portal perfusion (PP), and hepatic perfusion index (HPI) were calculated in the normal liver parenchyma and HCC samples. Results: A total of 21 histologically proven HCC lesions were evaluated from CT perfusion images. BF, BV, AP, and HPI values were shown to be significantly higher (P < 0.05) in the HCC lesions than in the normal liver parenchyma. Conversely, PP values were found to be significantly lower (P < 0.05) in HCC relative to liver parenchyma. Conclusion: CT perfusion imaging has the ability to evaluate tumor assessment, characterization, and neoangiogenesis in HCC.

Evaluation of hepatocellular carcinoma with computed tomography perfusion imaging

To evaluate the role of computed tomography (CT) perfusion imaging in patients with hepatocellular carcinoma (HCC). Materials and methods: Seventeen patients (9 men, 8 women) with newly diagnosed HCC, proven by biopsy, were evaluated with 256-slice helical CT. Perfusion parameters of blood flow (BF), blood volume (BV), arterial perfusion (AP), portal perfusion (PP), and hepatic perfusion index (HPI) were calculated in the normal liver parenchyma and HCC samples. Results: A total of 21 histologically proven HCC lesions were evaluated from CT perfusion images. BF, BV, AP, and HPI values were shown to be significantly higher (P < 0.05) in the HCC lesions than in the normal liver parenchyma. Conversely, PP values were found to be significantly lower (P < 0.05) in HCC relative to liver parenchyma. Conclusion: CT perfusion imaging has the ability to evaluate tumor assessment, characterization, and neoangiogenesis in HCC.

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  • Palma LD. Diagnostic imaging and interventional therapy of hepatocellular carcinoma. Br J Radiol 1998; 71: 808–18. Wong R, Frenette C. Updates in the management of hepatocellular carcinoma. Gastroenterol Hepatol 2011; 7: 16–24.
  • Yang L, Zhang XM, Tan BX, Liu M, Dong GL, Zhai ZH. Computed tomographic perfusion imaging for the therapeutic response of chemoembolization for hepatocellular carcinoma. J Comput Assist Tomogr 2012; 36: 226–30.
  • Koşar PN, Koçak Tufan Z, Ergün E, Yiğit H, Koşar U, Demiröz AP. Chest radiography and computed tomography findings of cases with pandemic influenza A (H1N1/09) infection. Turk J Med Sci 2012; 42: 787–95.
  • Miles KA. Perfusion CT for the assessment of tumor vascularity: which protocol? Br J Radiol 2003; 76: 36–42. Miles KA, Hayball MP, Dixon AK. Functional images of hepatic perfusion obtained with dynamic CT. Radiology 1993; 188: 405–11.
  • Zhu AX, Holalkere NS, Muzikansky A, Horgan K, Sahani DV. Early antiangiogenic activity of bevacizumab evaluated by computed tomography perfusion scan in patients with advanced hepatocellular carcinoma. Oncologist 2008; 13: 120–5.
Turkish Journal of Medical Sciences-Cover
  • ISSN: 1300-0144
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK
Sayıdaki Diğer Makaleler

Comparison of different ligation techniques in laparoscopic varicocelectomy*

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Relationship of admission neutrophil-to-lymphocyte ratio with in-hospital mortality in patients with acute type-I aortic dissection

Relationship of admission neutrophil-to- Dissection

MEFV mutation frequency and effect on disease severity in ankylosing spondylitis

Yüksel MARAŞ, Ali AKDOĞAN, Bünyamin KISACIK, Levent KILIÇ, Engin YILMAZ, Abdurrahman TUFAN, Umut KALYONCU, Şaziye Şule APRAŞ BİLGEN, Sedat KİRAZ, Ali İhsan ERTENLİ, Meral ÇALGÜNERİ

A comparison of the effects of hyperbaric and isobaric bupivacaine spinal anesthesia on hemodynamics and heart rate variability*

Gülşen BİCAN, İlke İŞİTEMİZ, Tümay YANARAL ULUDAĞ, İbrahim AKKOÇ, Sinan UZMAN, Mehmet TOPTAŞ

Relationship of admission neutrophil-to-lymphocyte ratio with in-hospital mortality in patients with acute type I aortic dissection

Ömer Faruk ÇİÇEK, Hacı Alper UZUN, Adnan YALÇINKAYA, İrfan TAŞOĞLU, Gökhan LAFÇI, Orhan Eren GÜNERTEM, Kemal KORKMAZ, Hikmet Selçuk GEDİK, Kerim ÇAĞLI, Kumral ÇAĞLI, Osman TURAK, Adem İlkay DİKEN

Evaluation of 48-week response of treatment-naive chronic hepatitis B patients to 0.5 mg/day entecavir

Servet KÖLGELİER, Nazlım Aktuğ DEMİR, Serap ÖZÇİMEN, Şua SÜMER

Comparison of disc and body volumes in degenerated and nondegenerated lumbar discs: a stereological study

Tuncay KANER, Ahmet SONGUR, Muhsin TOKTAŞ, Ozan Alper ALKOÇ, Olcay ESER, Mustafa EFENDİOĞLU

Expression of NADPH-d in the vagal nuclei of the chronic esophagitis model in rats

Ümit Süleyman ŞEHİRLİ, Halil TUĞTEPE, Ural VERİMLİ, Özlem KİRAZLI, Mazhar ÖZKAN, Emrullah Tolga DAĞLI

Assessment of left ventricular function by strain strain rate echocardiography in patients with celiac disease

Osman ERSOY, Hüseyin AYHAN, Cenk SARI, Serdal BAŞTUĞ, Fatma Ebru AKIN, Nihal BAYRAM AKAR, Aylin BOLAT DEMİREZER, Sevil SARI ÖZER, Emine BİLEN, Telat KELEŞ, Tahir DURMAZ, Engin BOZKURT

Efficacy of resuscitation with Intralipid in a levobupivacaine-induced cardiac arrest model

Murat KARCIOĞLU, Kasım TUZCU, Fatih SEFİL, Işıl DAVARCI, Suzan AYDIN, Ali SARI, Akın AYDOĞAN, Raif ÖZDEN