Erythrocyte TAO and TBARS levels in patients who suffered missed miscarriage

Aim: Missed miscarriage is a pregnancy-related condition, and lipid peroxidation and alterations in antioxidant levels may be of importance in the pathogenesis of this disorder. The aim of the study was to assess whether erythrocyte total antioxidant activity (TAO) and thiobarbituric acid reactive substance (TBARS) levels altered in patients who suffered missed miscarriage. Materials and methods: We measured levels of TAO and TBARS, as a lipid peroxidation marker, in erythrocytes of women with a diagnosed missed miscarriage (n = 36) during 7-16 weeks of pregnancy. The control group consisted of women (n = 34) with uncomplicated pregnancy similarly matched for maternal and gestational age. Results: We found a statistically significant decrease in erythrocyte TAO values in cases with missed miscarriage when compared to healthy pregnant group (P < 0.01). Additionally, mean TBARS levels were significantly higher in the missed miscarriage group than in the controls (P < 0.001). There was a negative correlation between erythrocyte TAO and TBARS (r = -0.60, P = 0.0001 for the missed miscarriage group and r = -0.44, P = 0.009 for the control group). Conclusion: The obtained results indicate that in erythrocytes oxidant-antioxidant defense system may be impaired in missed miscarriage.

Erythrocyte TAO and TBARS levels in patients who suffered missed miscarriage

Aim: Missed miscarriage is a pregnancy-related condition, and lipid peroxidation and alterations in antioxidant levels may be of importance in the pathogenesis of this disorder. The aim of the study was to assess whether erythrocyte total antioxidant activity (TAO) and thiobarbituric acid reactive substance (TBARS) levels altered in patients who suffered missed miscarriage. Materials and methods: We measured levels of TAO and TBARS, as a lipid peroxidation marker, in erythrocytes of women with a diagnosed missed miscarriage (n = 36) during 7-16 weeks of pregnancy. The control group consisted of women (n = 34) with uncomplicated pregnancy similarly matched for maternal and gestational age. Results: We found a statistically significant decrease in erythrocyte TAO values in cases with missed miscarriage when compared to healthy pregnant group (P < 0.01). Additionally, mean TBARS levels were significantly higher in the missed miscarriage group than in the controls (P < 0.001). There was a negative correlation between erythrocyte TAO and TBARS (r = -0.60, P = 0.0001 for the missed miscarriage group and r = -0.44, P = 0.009 for the control group). Conclusion: The obtained results indicate that in erythrocytes oxidant-antioxidant defense system may be impaired in missed miscarriage.

Kaynakça

Hemminki E. Treatment of miscarriage: current practice and rationale. Obstet Gynecol 1998; 91(2): 247–53. 2. Laferla JJ. Spontenous abortion. Clin Obstet Gynaecol 1986; 13(1): 105-14. 3.

Harger JH, Archer DF, Marchese SG, Muracca-Clemens M,

Garver KL. Etiology of recurrent pregnancy losses and outcome

Walsh SW, Wang Y. Deficient glutathione peroxidase activity in preeclampsia is associated with increased placental production of thromboxane and lipid peroxides. Am J Obstet Gynecol 1993; 169(6): 1456-61.

Nemec A, Drobnic-Kosorok M, Skitek M, Pavlica Z, Galac S, Butinar J. Total antioxidant capacity (TAC) values and their correlation with individual antioxidants in serum of healthy beagles. Acta Veterinaria Brno 2000; 69(5): 297–303

Aydin A, Orhan H, Sayal A, Özata M, Şahin G, Isimer A. Oxidative stress and nitric oxide related parameters in type II diabetes mellitus: effects of glycemic control. Clin Biochem 2001; 34(1): 65–70.

Erel O. A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem 2004; 37(2): 112–19.

Bayhan G, Atamer Y, Atamer A, Yokus B, Baylan Y. Significance of changes in lipid peroxides and antioxidant enzyme activities in pregnant women with preeclampsia and eclampsia. Clin Exp Obstet Gynecol 2000; 27(2): 142–46.

Myatt L, Cui X. Oxidative stres in the placenta. Histochem Cell Biol 2004; 122(4): 369-82.

Zachara BA, Dobrzynski W, Trafikowska U, Szymanski W. Blood selenium and gutathione peroxidase in miscarriage. Br J Obstet Gynaecol 2001; 108(3): 244-47.

Wall PD, Pressman EK, Woods JR. Preterm premature rupture of the membranes and antioxidants: the free radical connection. J Perinat Med 2002; 30(6): 447-57.

Myatt L, Cui X. Oxidative stress in the placenta. Histochem Cell Biol 2004; 122(4): 369-82.

Takagi Y, Nikaido T, Toki T, Kita N, Kanai M, Ashida T et al. Levels of oxidative stress and redox-related molecules in the placenta in preeclampsia and fetal growth restriction. Virchows Arch 2004; 444(1): 49-55.

Harma M, Erel O. Increased oxidative stress in patients with hydatidiform mole. Swiss Med Wkly 2003; 133(41-42): 563-66.

Lagod L, Paszkowski T, Skorski R, Rola R. The antioxidant- prooxidant balance in pregnancy complicated by spontaneous abortion. Gynecol Pol 2001; 72(12): 1073-78.

Hempstock J, Jauniaux E, Greenwold N, Burton GJ. The contribution of placental oxidative stress to early pregnancy failure. Hum Pathol 2003; 34(12): 1265-75.

Burton GJ, Jauniaux E. Placental oxidative stress; from miscarriage to preeclampsia. J Soc Gynecol Investig 2004; 11(6): 342-52.

Jauniaux E, Hempstock J, Greenwold N, Burton GJ. Trophoblastic oxidative stress in relation to temporal and regional differences in maternal placental blood flow in normal and abnormal early pregnancies. Am J Pathol 2003; 162(1): 115- 25.

Ozkaya O, Sezik M, Kaya H. Serum malondialdehyde, erythrocyte glutathione peroxidase, and erythrocyte superoxide dismutase levels in women early spontaneous abortions accompanied by vaginal bleeding. Med Sci Monit 2008; 14(1): 47-51.

Vural P, Akgül C, Yıldırım A, Canbaz M. Antioxidant defense in recurrent abortion. Clin Chim Acta 2000; 295(1-2): 169-77.

Kaynak Göster

Bibtex @ { tbtkmedical147461, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2009}, volume = {39}, pages = {881 - 885}, doi = {}, title = {Erythrocyte TAO and TBARS levels in patients who suffered missed miscarriage}, key = {cite}, author = {Aksoy, Ayşe Nur} }
APA Aksoy, A . (2009). Erythrocyte TAO and TBARS levels in patients who suffered missed miscarriage . Turkish Journal of Medical Sciences , 39 (6) , 881-885 .
MLA Aksoy, A . "Erythrocyte TAO and TBARS levels in patients who suffered missed miscarriage" . Turkish Journal of Medical Sciences 39 (2009 ): 881-885 <
Chicago Aksoy, A . "Erythrocyte TAO and TBARS levels in patients who suffered missed miscarriage". Turkish Journal of Medical Sciences 39 (2009 ): 881-885
RIS TY - JOUR T1 - Erythrocyte TAO and TBARS levels in patients who suffered missed miscarriage AU - Ayşe Nur Aksoy Y1 - 2009 PY - 2009 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 881 EP - 885 VL - 39 IS - 6 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2021 ER -
EndNote %0 Turkish Journal of Medical Sciences Erythrocyte TAO and TBARS levels in patients who suffered missed miscarriage %A Ayşe Nur Aksoy %T Erythrocyte TAO and TBARS levels in patients who suffered missed miscarriage %D 2009 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 39 %N 6 %R %U
ISNAD Aksoy, Ayşe Nur . "Erythrocyte TAO and TBARS levels in patients who suffered missed miscarriage". Turkish Journal of Medical Sciences 39 / 6 (Haziran 2009): 881-885 .
AMA Aksoy A . Erythrocyte TAO and TBARS levels in patients who suffered missed miscarriage. Turkish Journal of Medical Sciences. 2009; 39(6): 881-885.
Vancouver Aksoy A . Erythrocyte TAO and TBARS levels in patients who suffered missed miscarriage. Turkish Journal of Medical Sciences. 2009; 39(6): 881-885.
IEEE A. Aksoy , "Erythrocyte TAO and TBARS levels in patients who suffered missed miscarriage", Turkish Journal of Medical Sciences, c. 39, sayı. 6, ss. 881-885, Haz. 2009