Şebnem GÜRSOY, Nevzat ÖZCAN, Alper YURCİ, Ertuğrul MAVİLİ, Arzu TAŞDEMİR, Işın SOYUER

Endoscopic biliary tract brush cytology in 54 cases

Duct brushing cytology is an important tool in the evaluation of the extrahepatic biliary tract. New liquid-based preparations and ancillary tests have emerged with the intent of addressing this issue. Materials and methods: Fifty-four consecutive patients and 68 specimens with a suspected malignant obstruction of the common bile duct were included in a consecutive, nonrandomized order. We selected patients whose follow-up, in the form of either histology (25/54, 46%) or at least 6 months of clinical observation, was available. They underwent sampling during ERCP (33 patients/40 materials) or PTC (21 patients/28 materials) using the brush method. Results: A total of 68 specimens were identified from 54 patients. The cytologic findings were: 35% benign, 37% malignant, and 9% suspicious for malignancy. Overall operating characteristics were: 48% sensitivity, 100% specificity, 100% positive predictive value, 69% negative predictive value, and 75% accuracy. For the diagnosis of malignant stenosis, the sensitivity was 48% for cytology, 60% for biopsies, and 50% for the combination of cytology and biopsies. In addition, the Cytospin method showed more cellularity compared with the other preparation method (n = 68 materials; 57% Cytospin, 38% direct smear). Conclusion: Diagnosis of malignant biliary stenosis may be improved by a combination of endobiliary sampling and cytology.

Anahtar Kelimeler:

Key words: Extrahepatic biliary tract, liquid-based cytology

Endoscopic biliary tract brush cytology in 54 cases

Keywords:

Key words: Extrahepatic biliary tract, liquid-based cytology,

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