Effects of Gingko Glycosid (EGb 761) on Some Vascular Endothelial Functions and Renal Histology in Rabbits With Acute Cyclosporine Nephrotoxicity

In recent years, Endothelin-1 (ET-1), Platelet Activating Factor (PAF) and thromboxane have been considered responsible for the pathogenesis of acute cyclosporine nephrotoxicity (ACN). The aim of this study was to investigate the effects of the PAF antagonist gingko glycosid (EGb 761) on both renal histology and ET-1 and Nitric Oxide (NO) levels in experimental ACN. This study was carried out on 30 albino rabbits, divided into three groups. They were: group A (n=10) the control, group B (n=10), which was given intravenous cyclosporine (15mg/kg/day) and group C (n=10), which was given oral gingko glycosid (2.5mg/kg/day) in addition to cyclosporine. Plasma ET-1 and NO levels and renal histology were investigated in all of the groups. Data analysis was performed by Kruskall-Wallis one-way Anova and Mann Whitney-U tests. Plasma ET-1 levels in groups B and C were higher than in the controls (p

Effects of Gingko Glycosid (EGb 761) on Some Vascular Endothelial Functions and Renal Histology in Rabbits With Acute Cyclosporine Nephrotoxicity

In recent years, Endothelin-1 (ET-1), Platelet Activating Factor (PAF) and thromboxane have been considered responsible for the pathogenesis of acute cyclosporine nephrotoxicity (ACN). The aim of this study was to investigate the effects of the PAF antagonist gingko glycosid (EGb 761) on both renal histology and ET-1 and Nitric Oxide (NO) levels in experimental ACN. This study was carried out on 30 albino rabbits, divided into three groups. They were: group A (n=10) the control, group B (n=10), which was given intravenous cyclosporine (15mg/kg/day) and group C (n=10), which was given oral gingko glycosid (2.5mg/kg/day) in addition to cyclosporine. Plasma ET-1 and NO levels and renal histology were investigated in all of the groups. Data analysis was performed by Kruskall-Wallis one-way Anova and Mann Whitney-U tests. Plasma ET-1 levels in groups B and C were higher than in the controls (p
Turkish Journal of Medical Sciences-Cover
  • ISSN: 1300-0144
  • Yayın Aralığı: 6
  • Yayıncı: TÜBİTAK
Sayıdaki Diğer Makaleler

Serum Carnitine Levels in Patients with Coronary Artery Disease

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MRI in Joubert syndrome

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Isoniazid poisoning with seizures, shoulder dislocation, and fracture of the greater tuberosity

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Preparation of Bovine Serum Albumin Microspheres Containing Dexamethasone Sodium Phosphate and the in Vitro Evaluation

Levent ÖNER, Hakan EROĞLU, H. Süheyla KAŞ, Mustafa SARGON, A. Atilla HINCAL

Prevalence of Diabetes Mellitus and Affected Factors in the District of Kayseri Health Group Area

Yusuf ÖZTÜRK, Mualla AYKUT, Mücahit EĞRİ, Osman GÜNAY, Fahrettin KELEŞTİMUR, Osman CEYHAN, Fevziye ÇETİNKAYA

Obesity and the Activity of the Autonomic Nervous System

Emir DÖNDER, Ramis ÇOLAK, Oğuz AYHAN, Aziz KARAOĞLU, Mehmet YALNIZ

Experimentally Developed Secondary Echinococcosis in Pleural and Peritoneal Cavities and the Utility of Serological Tests During the Follow up

Kadir KAZEZ, Yücel ARITAŞ, Celalettin VATANSEV, Faruk AKSOY, Hüsamettin VATANSEV, Mustafa ŞAHİN

Analysis of K-Ras Oncogene Codon 12 Mutations in a Series of Human Lung Cancers

Wayne E. CRISS, Fahriye DEMİRAĞ, Erol ATALAY

Alprazolam and Cognitive Behavior Therapy in Treatment of Panic Disorder

Ahmet ATAOĞLU, Hamdi TUTKUN, Abdullah MARAŞ, Mustafa ÖZKAN

The Importance of Fibronectin, Haptoglobin, Ceruloplasmin and Transferrin in the Early Diagnosis of Neonatal Sepsis

Ayhan Gazi KALAYCI, Recep SANCAK, Bahattin ADAM, Fazlı YILMAZER, Şükrü KÜÇÜKÖDÜK