Rafiye ÇİFTÇİLER, Nejat AKAR, Ahmet KOLUMAN, İbrahim C. HAZNEDAROĞLU

Effects of Ankaferd Hemostat on Helicobacter pylori strains and antibiotic resistance

Background/aim: Ankaferd hemostat (ABS; Ankaferd blood stopper, İstanbul, Turkey) is a folkloric medicinal plant extract. The aimof this study was to determine the effect of Ankaferd hemostat (ABS) on the fate of Helicobacter pylori strains. The study also aims todetermine alterations in the antimicrobial resistance of three different H. pylori strains in response to ABS exposure.Materials and methods: H. pylori Strain 1 was obtained from the culture collection ATCC 43504 and passaged three times for viability.Strain 2 was isolated from a gastric ulcer patient and Strain 3 was isolated from a gastritis patient. 1% of ABS was added to all of thestrains and antimicrobial susceptibility was observed on 30 and 60 min after application.Results: The efficacy of ABS solutions in achieving significant logarithmic reduction in foodborne pathogens of H. pylori was observedin this study. This study showed that ABS has antibacterial (Anti-H. pylori) effects.Conclusion: Our present study indicated, for the first time, that ABS could act against H. pylori. ABS is clinically used for themanagement of GI bleeding due to benign and malignant GI lesions. Thus, the possible anti-H. pylori effect of ABS shall expand thetherapeutic spectrum of the drug in GI lesions in relation to H. pylori infection such as peptic ulser disease (PUD) and lymphoid tissue(MALT) lymphomagenesis.

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