Dual energy CT in necrotizing enterocolitis; a novel diagnostic approach

Dual energy CT in necrotizing enterocolitis; a novel diagnostic approach

Background/aim: Necrotizing enterocolitis (NEC) is one of the most important causes of morbidity and mortality in premature infants. Although there are no specific diagnostic tools, the main factors affecting prognosis are clinical and laboratory findings, and early diagnosis and treatment. In this study, we demonstrate the importance of dual-energy computed tomography (DECT) in confirming intestinal ischemia in neonates with NEC. Materials and methods: Patients diagnosed with NEC in a neonatal intensive care unit were staged according to modified Bell’s classification, and DECT was performed on patients with NEC stages 2-A, 2-B and 3-A. According to their DECT reports, these patients were then separated into two groups: those with intestinal ischemia and those without intestinal ischemia. The patients with intestinal ischemia were evaluated using surgical reports, and the other patients were evaluated using clinical findings. Results: DECT was performed in 21 patients with NEC stages 2-A, 2-B and 3-A. Twelve patients (57.1%) without ischemia were followed up without surgery. Nine patients (42.9%) with ischemia on DECT were operated on, and resection and anastomosis or ileostomy and colostomy were performed. Conclusion: In patients with NEC, DECT significantly increases overall diagnostic confidence in assessing intestinal necrosis when compared with traditional diagnostic methods.Key words: Dual-energy computed tomography, necrotizing enterocolitis, newborn

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  • 1. Tepas JJ, 3rd, Sharma R, Leaphart CL, Celso BG, Pieper P et al. Timing of surgical intervention in necrotizing enterocolitis can be determined by trajectory of metabolic derangement. Journal of Pediatric Surgery. 2010; 45(2):310-313. doi: 10.1016/j. jpedsurg.2009.10.069
  • 2. Rowe MI, Reblock KK, Kurkchubasche AG, Healey PJ. Necrotizing enterocolitis in the extremely low birth weight infant. Journal of Pediatric Surgery. 1994; 29(8): 987-990. doi: 10.1016/0022-3468(94)90264-x
  • 3. Comert H, Sarihan H, Saygin I, Imamoglu M, Basar D et al. Effects of Peritoneal Dialysis Solution on Experimental Necrotizing Enterocolitis in Newborn Rats. SN Comprehensive Clinical Medicine. 2019; 1: 547-551. doi: 10.1007/s42399-019- 00079-0
  • 4. Lee JS, Polin RA. Treatment and prevention of necrotizing enterocolitis. Seminars in Neonatology : SN. 2003; 8(6): 449- 459. doi: 10.1016/S1084-2756(03)00123-4
  • 5. Jesse N, Neu J. Necrotizing Enterocolitis: Relationship to Innate Immunity, Clinical Features, and Strategies for Prevention 2006 (7). doi: 10.1542/NEO.7-3-E143
  • 6. Tam AL, Camberos A, Applebaum H. Surgical decision making in necrotizing enterocolitis and focal intestinal perforation: predictive value of radiologic findings. Journal of Pediatric Surgery. 2002; 37(12): 1688-1691. doi: 10.1053/jpsu.2002.36696
  • 7. D’Angelo T, Cicero G, Mazziotti S, Ascenti G, Albrecht MH et al. Dual energy computed tomography virtual monoenergetic imaging: technique and clinical applications. The British Journal of Radiology. 2019; 92(1098): 20180546. doi: 10.1259/ bjr.20180546
  • 8. Sade R, Kantarci M, Ogul H, Bayraktutan U, Uzkeser M, Aslan S et al. The Feasibility of Dual-Energy Computed Tomography in Cardiac Contusion Imaging for Mildest Blunt Cardiac Injury. Journal of Computer Assisted Tomography. 2017; 41(3): 354- 359. doi: 10.1097/RCT.0000000000000545
  • 9. Coursey CA, Nelson RC, Boll DT, Paulson EK, Ho LM et al. Dualenergy multidetector CT: how it work, what can it tell us, and when can we use it in abdominopelvic imaging? Radiographics. 2010; 30(4): 1037-1055. doi: 10.1148/rg.304095175
  • 10. Karaca L, Yuceler Z, Kantarci M, Cakir M, Sade R et al. The feasibility of dual-energy CT in differentiation of vertebral compression fractures. The British Journal of Radiology. 2016; 89(1057): 20150300. doi: 10.1259/bjr.20150300
  • 11. Boll DT, Merkle EM, Paulson EK, Mirza RA, Fleiter TR. Calcified vascular plaque specimens: assessment with cardiac dual-energy multidetector CT in anthropomorphically moving heart phantom. Radiology. 2008; 249(1): 119-126. doi: 10.1148/ radiol.2483071576
  • 12. Hunter CJ, Chokshi N, Ford HR. Evidence vs experience in the surgical management of necrotizing enterocolitis and focal intestinal perforation. Journal of Perinatology. 2008; 28 Suppl 1: S14-7. doi: 10.1038/jp.2008.44
  • 13. Eaton S. Necrotizing enterocolitis symposium: Epidemiology and early diagnosis. Journal of Pediatric Surgery. 2017; 52(2): 223-225. doi: 10.1016/j.jpedsurg.2016.11.013
  • 14. Neu J. NICHD: AAP workshop on neonatology research and training areas of research in neonatal gastroenterology. Journal of Perinatology. 2006; 26 Suppl 2: S19-22. doi: 10.1038/ sj.jp.7211424
  • 15. Evennett NJ, Hall NJ, Pierro A, Eaton S. Urinary intestinal fatty acid-binding protein concentration predicts extent of disease in necrotizing enterocolitis. Journal of Pediatric Surgery. 2010; 45(4): 735-740. doi: 10.1016/j.jpedsurg.2009.09.024
  • 16. Sharma R, Tepas JJ, 3rd, Hudak ML, Wludyka PS, Mollitt DL et al. Portal venous gas and surgical outcome of neonatal necrotizing enterocolitis. Journal of Pediatric Surgery. 2005; 40(2): 371-6. doi: 10.1016/j.jpedsurg.2004.10.022
  • 17. Dilli D, Suna Oguz S, Erol R, Ozkan-Ulu H, Dumanli H et al. Does abdominal sonography provide additional information over abdominal plain radiography for diagnosis of necrotizing enterocolitis in neonates? Pediatric Surgery International. 2011; 27(3): 321-327. doi: 10.1007/s00383-010-2737-8
  • 18. Coursey CA, Hollingsworth CL, Gaca AM, Maxfield C, Delong D et al. Radiologists’ agreement when using a 10-point scale to report abdominal radiographic findings of necrotizing enterocolitis in neonates and infants. American Journal of Roentgenology. 2008; 191(1): 190-7. doi: 10.2214/ajr.07.3558
  • 19. Rees CM, Hall NJ, Eaton S, Pierro A. Surgical strategies for necrotising enterocolitis: a survey of practice in the United Kingdom. Archives of Disease in Childhood Fetal and Neonatal Edition. 2005; 90(2): F152-5. doi: 10.1136/adc.2004.051862
  • 20. Dominguez MK, Moss RL. Necrotizing Enterocolitis. In: Ashcraft KW, Holcomb GW, Murphy JP, Ostlie DJ, editors. Ashcraft’s Pediatric Surgery. 6th ed: Saunders/Elsevier; 2010. p. 454-473.
  • 21. Muchantef K, Epelman M, Darge K, Kirpalani H, Laje P et al. Sonographic and radiographic imaging features of the neonate with necrotizing enterocolitis: correlating findings with outcomes. Pediatric Radiology. 2013; 43(11): 1444-1452. doi: 10.1007/s00247-013-2725-y
  • 22. Akin MA, Yikilmaz A, Gunes T, Sarici D, Korkmaz L et al. Quantitative assessment of hepatic blood flow in the diagnosis and management of necrotizing enterocolitis. The journal of Maternal-Fetal & Neonatal Medicine. 2015; 28(18): 2160-5. doi: 10.3109/14767058.2014.980230
  • 23. Faingold R, Daneman A, Tomlinson G, Babyn PS, Manson DE et al. Necrotizing enterocolitis: assessment of bowel viability with color doppler US. Radiology. 2005; 235(2): 587-94. doi: 10.1148/ radiol.2352031718
  • 24. Tan HL, Tantoco JG, Ee MZ. The role of diagnostic laparoscopy in micropremmies with suspected necrotizing enterocolitis. Surgical Endoscopy. 2007; 21(3): 485-7. doi: 10.1007/s00464- 006-9030-x
  • 25. Pierro A, Hall N, Ade-Ajayi A, Curry J, Kiely Em EM. Laparoscopy assists surgical decision making in infants with necrotizing enterocolitis. Journal of Pediatric Surgery. 2004; 39(6): 902-906. doi: 10.1016/j.jpedsurg.2004.02.006
  • 26. Paral J, Ferko A, Plodr M, Raupach J, Hadzi-Nikolov D et al. Laparoscopic diagnostics of acute bowel ischemia using ultraviolet light and fluorescein dye: an experimental study. Surgical Laparoscopy, Endoscopy & Percutaneous Techniques. 2007; 17(4): 291-295. doi: 10.1097/SLE.0b013e3180dc9376
  • 27. Kurland B, Brandt LJ, Delany HM. Diagnostic tests for intestinal ischemia. The Surgical Clinics of North America. 1992; 72(1): 85-105. doi: 10.1016/s0039-6109(16)45629-x
  • 28. Horstmann R, Palmes D, Rupp D, Hohlbach G, Spiegel HU. Laparoscopic fluorometry: a new minimally invasive tool for investigation of the intestinal microcirculation. Journal of Investigative Surgery. 2002; 15(6): 343-350. doi: 10.1080/08941930290086164
  • 29. Numanoglu A, Millar AJ. Necrotizing enterocolitis: early conventional and fluorescein laparoscopic assessment. Journal of Pediatric Surgery. 2011; 46(2): 348-351. doi: 10.1016/j. jpedsurg.2010.11.021
  • 30. Goske MJ, Strauss KJ, Coombs LP, Mandel KE, Towbin AJ et al. Diagnostic reference ranges for pediatric abdominal CT. Radiology. 2013; 268(1): 208-218. doi: 10.1148/radiol.13120730
  • 31. Rathnayake S, Mongan J, Torres AS, Colborn R, Gao DW et al. In vivo comparison of tantalum, tungsten, and bismuth enteric contrast agents to complement intravenous iodine for double-contrast dual-energy CT of the bowel. Contrast Media & Molecular Imaging. 2016; 11(4): 254-261. doi: 10.1002/ cmmi.1687
  • 32. Lee SM, Kim SH, Ahn SJ, Kang HJ, Kang JH et al. Virtual monoenergetic dual-layer, dual-energy CT enterography: optimization of keV settings and its added value for Crohn’s disease. European Radiology. 2018; 28(6): 2525-2534. doi: 10.1007/s00330-017-5215-z
  • 33. Lourenco PDM, Rawski R, Mohammed MF, Khosa F, Nicolaou S et al. Dual-Energy CT Iodine Mapping and 40-keV Monoenergetic Applications in the Diagnosis of Acute Bowel Ischemia. American Journal of Roentgenology. 2018; 211(3): 564-570. doi: 10.2214/AJR.18.19554
  • 34. Yeh BM, Obmann MM, Westphalen AC, Ohliger MA, Yee J et al. Dual Energy Computed Tomography Scans of the Bowel: Benefits, Pitfalls, and Future Directions. Radiologic Clinics of North America. 2018; 56(5): 805-819. doi: 10.1016/j. rcl.2018.05.002
Turkish Journal of Medical Sciences-Cover
  • ISSN: 1300-0144
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK
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