Could serum albumin value and thrombocyte/lymphocyte ratio be an important prognostic factor in determining the severity of COVID 19?
Could serum albumin value and thrombocyte/lymphocyte ratio be an important prognostic factor in determining the severity of COVID 19?
Background and aim: Creating potential clinical markers for risk assessment in patients with COVID-19 continues to be an area of interest. In this study, we aimed to evaluate whether serum albumin level and thrombocyte/lymphocyte ratio are related to the severity of the disease. Materials and methods: The patients were divided into two groups according to the severity of disease. Demographic data, serum albumin value, lymphocyte count, TLO-1 values (thrombocyte/lymphocyte ratio-1), the highest thrombocyte count during hospitalization, TLO-2 (thrombocyte/lymphocyte ratio-2) values formed by the highest thrombocyte count, were recorded. Results: There was no statistically significant differences (P > 0.05) in terms of sex, thrombocyte count at the time of admission, and highest thrombocyte count during hospital follow-up. There were statistically significant differences in terms of age, comorbidity, lymphocyte value at the time of hospitalization, lymphocyte count during hospital follow-up, TLO 1, TLO 2, and serum albumin values between the groups. The ICU group were found to be older, had higher rates of comorbidity, lower lymphocyte values, higher TLO 1-2, and lower serum albumin levels (P < 0.05). Conclusion: TLO-2 ratio above 260 and lymphocyte level below 1 103 cells/µL, would be a predictor of further intensive care unit need.Key words: Severity of COVID 19, platelet lenfosit ratio, serum albumin value
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- 1. Wenjie T, Xiang Z, Xuejun M, Wenling W, Peihua N, et al. A novel coronavirus genome identified in a cluster of pneumonia cases. China CDC Weekly 2020; 2 (4): 61-62.
- 2. Chaolin H, Yeming W, Xingwang L, Lili R, Jianping Z, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020; 395 (10223): 497- 506. doi: 10.1016/S0140-6736(20)30183-5
- 3. Chih-Cheng L, Cheng-Yi W, Ya-Hui W, Shun-Chung H, WenChien K, et al. Global epidemiology of coronavirus disease 2019 (COVID19): disease incidence, daily cumulative index, mortality, and their association with country healthcare resources and economic status. International Journal of Antimicrobial Agents 2020; 55 (4): 105946. doi: 10.1016/j. ijantimicag.2020. 105946
- 4. Zhang MQ, Wang XH, Chen YL, Zhao KL, Cai YQ, et al. Clinical features of 2019 novel coronavirus pneumonia in the early stage from a fever clinic in Beijing. Zhonghua Jie He He Hu Xi Za Zhi 2020; 43 (3): 215-218 (in Chinese). doi: 10. 3760/ cma.j.issn.1001-0939.2020.0013
- 5. Li H, Wang YM, Xu JY, Cao B. Potential antiviral therapeutics for 2019 novel coronavirus. Zhonghua Jie He He Hu Xi Za Zhi 2020; 43 (0): E002 (in Chinese). doi: 10.3760/ cma.j.issn.1001-0939.2020.0002
- 6. Plebani M, Laposata M, Lippi G. A manifesto for the future of laboratory medicine professionals. Clinica Chimica Acta 2019; 489: 49-52. doi: 10.1016/j.cca.2018.11.021
- 7. Jenne CN, Kubes P. Thrombocytes in inflammation and infection. Thrombocytes 2015; 26 (4): 286-292. doi: 10.3109/09537104.2015.1010441
- 8. Güneş M, Büyükgöl H. Relationship between generalized epileptic seizure and neutrophil/lymphocyte ratio, thrombocyte/lymphocyte ratio, and neutrophil mediated inflammation. International Journal of Neuroscience 2020; 130 (11): 1095-1100. doi.10.1080/00207454.2020.1722662
- 9. Chen RF, Chang JC, Yeh WT, Lee CH, Liu JW et al. Role of vascular cell adhesion molecules and leukocyte apoptosis in the lymphopenia and thrombocytopenia of patients with severe acute respiratory syndrome (SARS). Microbes and Infection 2006; 8 (1): 122-127. doi: 10.1016/j.micinf.2005.06.007
- 10. Behrens K, Alexander WS. Cytokine control of megakaryopoiesis. Growth Factors 2018; 36 (3-4): 89-103. doi: 10.1080/08977194.2018.1498487
- 11. Dawei W, Bo H, Chang H, Fangfang Z, Xing L et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA 2020; e201585. doi: 10.1001/jama.2020.1585
- 12. Qu R, Ling Y, Zhang LHZ, Wei LY, Chen X et al. Platelet-tolymphocyte ratio is associated with prognosis in patients with coronavirus disease-19. Journal of Medical Virology 2020; 92: 1533-1541. doi: 10. 1002/jmv.25767
- 13. Huang Y, Yang R, Xu Y, Gong P. Clinical characteristics of 36 non-survivors with COVID-19 in Wuhan, China. medRxiv preprint 2020. doi: 10.1101/2020.02.27.20029009
- 14. Mauro B, Paolo A, Joan C, Richard M, Pere G et al. Albumin in decompensated cirrhosis: new concepts and perspectives. Gut 2020; 69: 1127-1138. doi: 10.1136/gutjnl-2019-318843
- 15. Li J, Li M, Zheng S, Li M, Zhang M et al. Plasma albumin levels predict risk for nonsurvivors in critically ill patients with COVID-19. Biomarkers in Medicine 2020; 14 (10): 827- 837. doi: 10.2217/bmm-2020-0254
- 16. Yingxia L, Yang Y, Cong Z, Fengming H, Fuxiang W et al. Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury. China Life Sciences 2020; 63 (3): 364-374. doi: 10.1007/s11427-020-1643-8
- 17. Wei L, Zhao-Wu T, Lei W, Ming-Li Y, Kui L et al. Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel Corona virus disease. Chinese Medical Journal 2020; 133 (9): 1032-1038. doi: 10.1097/ CM9.0000000000000775