Common SPINK-1 genetic mutations do not predispose to Crohn`s Disease

Common SPINK-1 genetic mutations do not predispose to Crohn`s Disease

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  • 1. Cho JH. The genetics and immunopathogenesis of inflammatory bowel disease. Nat Rev Immunol 2008; 8: 458- 466.
  • 2. Hugot JP, Chamaillard M, Zouali H, Lesage S, Cézard JP, Belaiche J, Almer S, Tysk C, O’Morain CA, Gassull M et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn’s disease. Nature 2001; 31: 599-603.
  • 3. Schweitz H, Vincent JP, Lazdunski M. Trypsin--pancreatic secretory inhibitor (Kazal inhibitor) interaction. Kinetic and thermodynamic properties. Biochemistry 1973; 12: 2841-2846.
  • 4. Ohmachi Y, Murata A, Matsuura N, Yasuda T, Yasuda T, Monden M, Mori T, Ogawa M, Matsubara K. Specific expression of the pancreatic-secretory-trypsin-inhibitor (PSTI) gene in hepatocellular carcinoma. Int J Cancer 1993; 55: 728-734.
  • 5. Freeman TC, Playford RJ, Quinn C, Beardshall K, Poulter L, Young J, Calam J. Pancreatic secretory trypsin inhibitor in gastrointestinal mucosa and gastric juice. Gut 1990; 31: 1318- 1323.
  • 6. Masamune A, Kume K, Takagi Y, Kikuta K, Satoh K, Satoh A. N34S mutation in the SPINK1 gene is not associated with alternative splicing. Pancreas 2000; 34: 423-428.
  • 7. Gasche C, Scholmerich J, Brynskov J, D’Haens G, Hanauer SB, Irvine EJ, Jewell DP, Rachmilewitz D, Sachar DB, Sandborn WJ et al. A simple classification of Crohn’s disease: report of the working party of the World Congresses of Gastroenterology, Vienna 1998. Inflamm Bowel Dis 2000; 6: 8-15.
  • 8. Witt H, Luck W, Hennies HC, Classen M, Kage A, Lass U, Landt O, Becker M. Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis. Nat Genet 2000; 25: 213-216.
  • 9. Marchbank T, Mahmood A, Fitzgerald AJ, Domin J, Butler M, Goodlad RA, Elia G, Cox HM, van Heel DA, Ghosh S et al . Human pancreatic secretory trypsin inhibitor stabilizes intestinal mucosa against noxious agents. Am J Pathol 2007; 171: 1462-1473.