Buse ÖZCAN KAHRAMAN, Sema SAVCI, Serap ACAR, Didem KARDİBAK, Can SEVİNÇ, Ebru ÖZPELİT, Bahri AKDENİZ

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Clinical correlation between the 6-min walk test and cardiopulmonary exercise testing in patients with pulmonary arterial hypertension

Clinical correlation between the 6-min walk test and cardiopulmonary exercise testing in patients with pulmonary arterial hypertension

Background/aim: The aims of the present study were to assess the relationship between the distance walked during the 6-min walk test (6MWT) and exercise capacity as determined by cardiopulmonary exercise testing (CPET) in patients with pulmonary arterial hypertension (PAH) and to investigate the prognostic value of the 6MWT in comparison to clinical parameters of CPET and echocardiography findings. Materials and methods: Thirty PAH patients participated in the study. Subject characteristics and New York Heart Association (NYHA) classifications were recorded. All subjects completed the 6MWT and CPET. Relationships among the variables were analyzed by the Pearson correlation test. Correlation coefficients between 6MWT distance and other variables were determined by linear regression analysis. Results: Distance walked in the 6MWT was significantly correlated with the following exercise parameters: peak oxygen consumption, work load, and metabolic equivalents. Additionally, cardiac index was correlated with peak oxygen consumption and metabolic equivalents. We also showed that cardiac index and age were two significant determinants for exercise performance, accounting for 35.4% of the variance in the 6MWT. Conclusion: The 6MWT provides information that may be a better index for the patient s NYHA functional class determination than maximal exercise testing.
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  • 1. Rubin LJ. Primary pulmonary hypertension. N Engl J Med 2011; 336: 111-117.
  • 2. Olschewski H, Kovacs G. ESC guidelines 2015 on pulmonary hypertension. Herz 2015; 4: 1055-1060.
  • 3. McLaughlin VV, Davis M, Cornwell W. Pulmonary arterial hypertension. Curr Probl Cardiol 2011; 36: 461-517.
  • 4. Paolillo S, Farina S, Bussotti M, Iorio A, Perrone Filardi P, Piepolil MF, Agostoni P. Exercise testing in the clinical management of patients affected by pulmonary arterial hypertension. Eur J Prev Cardiol 2011;19: 960-971.
  • 5. Naeije R. Breathing more with weaker respiratory muscles in pulmonary arterial hypertension. Eur Respir J 2003; 25: 6-8.
  • 6. McLaughlin VV, Archer SL, Badesch DB, Barst RJ, Farber HW, Lindner JR, Mathier MA, McGoon MD, Park MH, Rosenson RS et al. ACC/AHA 2009 expert consensus document on pulmonary hypertension. A report of the American College of Cardiology Foundation task force on expert consensus documents and the American Heart Association. Circulation 2009; 119: 2250-2294.
  • 7. Miyamoto S, Nagaya N, Satoh T, Kyotani S, Sakamaki F, Fujita M, Nakanishi N, Miyatake K. Clinical correlates and prognostic significance of six-minute walk test in patients with primary pulmonary hypertension comparison with cardiopulmonary exercise testing. Am J Respir Crit Care Med 2000; 161: 48-492.
  • 8. Sun X, Hansen JE, Oudiz RJ, Wasserman K. Exercise pathophysiology in patients with primary pulmonary hypertension. Circulation 2001; 104: 429-435.
  • 9. Fowler RM, Gain KR, Gabbay E. Exercise intolerance in pulmonary arterial hypertension. Pulmonary Medicine 2012; 2012: 359204.
  • 10. Groepenhoff H, Vonk-Noordegraaf A, van de Veerdonk MC, Boonstra A, Westerhof N, Bogaard HJ. Prognostic relevance of changes in  exercise test  variables in  pulmonary arterial hypertension. PLoS One 2013; 8: e72013.
  • 11. Guazzi M, Opasich C. Functional evaluation of patients with chronic pulmonary hypertension. Ital Heart 2005; 6: 789-794.
  • 12. Demir R,  Küçükoğlu MS. Six-minute walk  test  in  pulmonary arterial hypertension. Anatol J Cardiol 2015; 15: 249-254.
  • 13. Neal JE, Lee AS, Burger CD. Submaximal exercise testing may be superior to the 6-min walk test in assessing pulmonary arterial hypertension disease severity. Clin Respir J 2014; 8: 404-409.
  • 14. Inal-Ince D, Savci S, Saglam M, Calik E, Arikan H, Bosnak-Guclu M, Vardar-Yagli N, Coplu L. Fatigue and multidimensional disease severity in chronic obstructive pulmonary disease. Multidiscip Respir Med 2010; 5: 162-167.
  • 15. Selzer A, Sudrann RB. Reliability of the determination of cardiac output in man by means of the Fick principle. Circ Res 1958; 6: 485-490.
  • 16. ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. ATS Statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med 2002; 166: 111-117.
  • 17. Enright PL, McBurnie MA, Bittner V. The 6-min walk test: a quick measure of functional status in elderly adults. Chest 2003; 123: 387-398.
  • 18. Farber HW,  Miller DP,  McGoon MD,  Frost AE. Predicting outcomes in  pulmonary arterial hypertension  based on the 6-minute walk distance. J Heart Lung Transplant 2015; 34: 362-368.
  • 19. Britto RR, Probst VS, Andrade AFD. Reference equations for the six-minute walk distance based on a Brazilian multicenter study. Braz J Phys Ther 2013; 17: 556-563.
  • 20. Galie N, Simonneau G. The Fifth World Symposium on Pulmonary Hypertension. J Am Coll Cardiol 2013; 24: 1-3.
  • 21. Jefferson AL, Himali JJ, Beiser AS. Cardiac index is associated with brain aging: The Framingham Heart Study. Circulation 2010; 122: 690-697.
  • 22. Cahalin LP, Mathier MA, Semigran MJ, Dec GW, Di-Salvo TG. The six-minute walk test predicts peak oxygen uptake and survival in patients with advanced heart failure. Chest 1996; 110: 325-332.
Turkish Journal of Medical Sciences-Cover
  • ISSN: 1300-0144
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK
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