İlker YİĞİT, Berrin GÜNAYDIN, Ömer Hakan EMMEZ, Mecit Orhan ULUDAĞ, Nur Banu BAL, İsmail Tuncer DEĞİM

Antinociceptive Effect of Liposomal Bupivacaine Formulations After Intrathecal Administration in Rats

Öz Background/aim: Based on our previous in vitro study with multilamellar liposomal bupivacaine (MLB) versus bupivacaine alone in artificial cerebrospinal fluid, we aimed to investigate in vivo antinociceptive effect of intrathecal MLB by determining tail flick latency (TFL) time after thermal stimulation in rats. Materials and methods: After preparing MLB and high-yield drug entrapment in liposome (HYDEL) bupivacaine, 18 female Wistar rats were assigned to 3 groups as control (bupivacaine) and study groups (MLB and HYDEL bupivacaine) including 6 rats in each group to administer these drugs intrathecally. Antinociceptive activity was determined in terms of TFL time after thermal stimulation. Maximum possible effect (MPE) calculated from TFL times and rats with motor block were documented. Results: TFL times after intrathecal injection of HYDEL bupivacaine were significantly longer than that of the control and MLB groups (P < 0.05) and returned to baseline 180 min after intrathecal injection. MPE (100%) with intrathecal HYDEL bupivacaine occurred between 10 to 45 min. Afterwards, MPEs were 70% and 50% for the control and MLB groups, respectively. Motor block disappeared after 20 min in the study groups while it lasted 75 min in the control.Conclusion: Intrathecal administration of MLB and HYDEL bupivacaine in rats resulted in longer duration of antinociceptive activity with shorter motor block duration.

Anahtar Kelimeler:

Extended release formulation, liposomal bupivacaine, intrathecal, rat

Tam Metin

Kaynak Göster

Bibtex	`@ { tbtkmedical577838, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2019}, volume = {49}, pages = {429 - 434}, doi = {}, title = {Antinociceptive Effect of Liposomal Bupivacaine Formulations After Intrathecal Administration in Rats}, key = {cite}, author = {Yiğit, İlker and Günaydın, Berrin and Emmez, Ömer Hakan and Uludağ, Mecit Orhan and Bal, Nur Banu and Değim, İsmail Tuncer} }`
APA	Yiğit, İ , Günaydın, B , Emmez, Ö , Uludağ, M , Bal, N , Değim, İ . (2019). Antinociceptive Effect of Liposomal Bupivacaine Formulations After Intrathecal Administration in Rats . Turkish Journal of Medical Sciences , 49 (1) , 429-434 . Retrieved from https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45750/577838
MLA	Yiğit, İ , Günaydın, B , Emmez, Ö , Uludağ, M , Bal, N , Değim, İ . "Antinociceptive Effect of Liposomal Bupivacaine Formulations After Intrathecal Administration in Rats" . Turkish Journal of Medical Sciences 49 (2019 ): 429-434 <https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45750/577838>
Chicago	Yiğit, İ , Günaydın, B , Emmez, Ö , Uludağ, M , Bal, N , Değim, İ . "Antinociceptive Effect of Liposomal Bupivacaine Formulations After Intrathecal Administration in Rats". Turkish Journal of Medical Sciences 49 (2019 ): 429-434
RIS	TY - JOUR T1 - Antinociceptive Effect of Liposomal Bupivacaine Formulations After Intrathecal Administration in Rats AU - İlker Yiğit , Berrin Günaydın , Ömer Hakan Emmez , Mecit Orhan Uludağ , Nur Banu Bal , İsmail Tuncer Değim Y1 - 2019 PY - 2019 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 429 EP - 434 VL - 49 IS - 1 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2021 ER -
EndNote	%0 Turkish Journal of Medical Sciences Antinociceptive Effect of Liposomal Bupivacaine Formulations After Intrathecal Administration in Rats %A İlker Yiğit , Berrin Günaydın , Ömer Hakan Emmez , Mecit Orhan Uludağ , Nur Banu Bal , İsmail Tuncer Değim %T Antinociceptive Effect of Liposomal Bupivacaine Formulations After Intrathecal Administration in Rats %D 2019 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 49 %N 1 %R %U
ISNAD	Yiğit, İlker , Günaydın, Berrin , Emmez, Ömer Hakan , Uludağ, Mecit Orhan , Bal, Nur Banu , Değim, İsmail Tuncer . "Antinociceptive Effect of Liposomal Bupivacaine Formulations After Intrathecal Administration in Rats". Turkish Journal of Medical Sciences 49 / 1 (Şubat 2019): 429-434 .
AMA	Yiğit İ , Günaydın B , Emmez Ö , Uludağ M , Bal N , Değim İ . Antinociceptive Effect of Liposomal Bupivacaine Formulations After Intrathecal Administration in Rats. Turkish Journal of Medical Sciences. 2019; 49(1): 429-434.
Vancouver	Yiğit İ , Günaydın B , Emmez Ö , Uludağ M , Bal N , Değim İ . Antinociceptive Effect of Liposomal Bupivacaine Formulations After Intrathecal Administration in Rats. Turkish Journal of Medical Sciences. 2019; 49(1): 429-434.
IEEE	İ. Yiğit , B. Günaydın , Ö. Emmez , M. Uludağ , N. Bal ve İ. Değim , "Antinociceptive Effect of Liposomal Bupivacaine Formulations After Intrathecal Administration in Rats", Turkish Journal of Medical Sciences, c. 49, sayı. 1, ss. 429-434, Şub. 2019