An unusual pathology with an undefined etiology: solitary fibrous tumors of the pleura
An unusual pathology with an undefined etiology: solitary fibrous tumors of the pleura
Background/aim: The aim of the present study was to evaluate the etiology and clinical and pathological behavior of solitary fibrous tumors of the pleura (SFTPs), as well as the most appropriate surgical approach and the results of long-term follow-up of this condition. Materials and methods: Clinical and long-term follow-up records of 14 patients who had surgery for SFTP between 2001 and 2014 were reviewed retrospectively. Etiological factors, diagnostic procedures, and clinical courses and outcomes for these patients were studied. Results: Of the 14 patients, 8 were male (57%) and 6 were female (43%) patients. The mean age was 54.14 ± 10.35 (41 75) years. There was no remarkable common etiological factor. Preoperative diagnosis was achieved only in 2 patients. Predominant symptoms were cough and chest pain. Complete resection was achieved in all patients. Video-assisted thoracic surgery (VATS) was performed in 8 patients. All but one patient were classified as having benign SFTP. The mean follow-up was 58.5 ± 41.4 (10 132) months and no recurrence was noted in the follow-up. Conclusion: These rarely seen tumors of the pleura are usually benign and asymptomatic and their preoperative diagnosis is difficult. Clinical and pathological behavior is still unpredictable and the treatment consists of complete resection. Minimally invasive techniques such as VATS are recommended for surgery if the tumor size is appropriate.
___
- 1. Briselli M, Mark EJ, Dickersin GR. Solitary fibrous tumors of the pleura: eight new cases and review of 360 cases in the literature. Cancer 1981; 47: 2678-2689.
- 2. De Perrot M, Fischer S, Bründler MA, Sekine Y, Keshavjee S. Solitary fibrous tumors of the pleura. Ann Thorac Surg 2002; 74: 285-293.
- 3. Magdeleinat P, Alifano M, Petino A, Le Rochais JP, Dulmet E, Galateau F, Icard P, Regnard JF. Solitary fibrous tumors of the pleura: clinical characteristics, surgical treatment and outcome. Eur J Cardio-thorac 2002; 21: 1087-1093.
- 4. Cardillo G, Facciolo F, Cavazzana A. O, Capece G, Gasparri R, Martelli M. Localized (solitary) fibrous tumors of the pleura: an analysis of 55 patients. Ann Thorac Surg 2000; 70: 1808-1812.
- 5. Mezzetti M, Panigalli T, Giudice F.L, Cappelli R, Giuliani L, Raveglia F, Meda S. Surgical experience of 15 solitary fibrous tumors of the pleura. Crit Rev Oncol Hemat 2003; 47: 29-33.
- 6. Suter M, Gebhard S, Boumghar M, Peloponisios N, Genton CY. Localized fibrous tumors of the pleura: 15 new cases and review of the literature. Eur J Cardio-thorac 1998; 14: 453-459.
- 7. Altıok T, Topçu S, Taştepe İ, Yazıcı Ü, Çetin G. Localized fibrous tumors of the pleura: clinical and surgical evaluation. Ann Thorac Surg 2003; 76: 892-895.
- 8. Torre W, Rogriguez-Spiteri N, Sola JJ, Delgado M. Localized fibrous tumors of the pleura: experience with 7 recent cases. Arch Bronconeumol 2004; 40: 329-332.
- 9. Jha V, Gil J, Teirstein AS. Familial solitary fibrous tumor of the pleura. Chest 2005; 127: 1852-1854.
- 10. Kohler M, Clarenbach C, Kestenholz P, Kurrer M, Steinert HC, Russi EW, Weder W. Diagnosis, treatment and long-term outcome of solitary fibrous tumors of the pleura. Eur J Cardiothorac 2007; 32: 403-408.
- 11. Breda C, Zuin A, Giuseppe M, Galligioni A, Rea F. Giant localized fibrous tumors of the pleura: report of three subsequent cases. Lung Cancer 2006; 52: 249-252.
- 12. Chang YL, Lee YC, Wu CT. Thoracic solitary fibrous tumors: clinical and pathological diversity. Lung Cancer 1999; 23: 53- 60.
- 13. Takahama M, Kushibe K, Kawaguchi T, Kimura M, Taniguchi S. Video-assisted thoracoscopic surgery is a promising treatment for solitary fibrous tumors of the pleura. Chest 2004; 125: 1144- 1147.
- 14. England DM, Hochholzer L, McCarthy MJ. Localized benign and malignant fibrous tumors of the pleura. A clinicopathologic review of 223 cases. Am J Surg Pathol 1988; 13: 640-658.
- 15. Carretta A, Bandiera A, Melloni G, Ciriaco P, Arrigoni G, Rizzo N, Negri G, Zannini P. Solitary fibrous tumors of the pleura: immunohistochemical analysis and evaluation of prognostic factors after surgical treatment. J Surg Oncol 2006; 94: 40-44.
- 16. Santambrogio L, Nosotti M, Palleschi A, Rosso L, Tosi D, De Simone M, Ciulla MM, Maggioni M, Cioffi U. Solitary fibrous tumor of the pleura presenting with syncope episodes when coughing. World J Surg Oncol 2008; 6: 86.
- 17. DAndrilli A, Andreetti C, İbrahim M, Rendina EA. The evolution of a pleural nodule into a giant fibrous tumor associated with hypoglycemic coma. Eur J Cardio-thorac 2007; 31: 955-957.
- 18. Cakan A, Cagirici U, Yuncu G, Yener AG. Giant benign fibrous tumor of the pleura in a pregnant woman: report of a case. Surg Today 2003; 33: 196-198.
- 19. Tastepe I, Alper A, Ozaydin H. E, Memis L, Cetin G. A case of multiple synchronous localized fibrous tumors of the pleura. Eur J Cardio-thorac 2000; 18: 491-494.
- 20. Nomori H, Horio H, Fuyuno G, Morinaga S. Contacting metastasis of a fibrous tumor of the pleura. Eur J Cardio-thorac 1997; 12: 928-930.
- 21. Weiss B, Horton DA. Preoperative embolization of a massive solitary fibrous tumor of the pleura. Ann Thorac Surg 2002; 73: 983-985.
- 22. Rena O, Filosso PL, Papalia E, Molinatti M, Di Marzio P, Maggi G, Oliaro A. Solitary fibrous tumors of the pleura: surgical treatment. Eur J Cardio-thorac 2001; 19: 185-189.
- 23. Boddaert G, Guiraudet P, Grand B, Venissac N, Le PimpecBarthes F, Mouroux J, Riquet M. Solitary fibrous tumors of the pleura: a poorly defined malignancy profile. Ann Thorac Surg 2015; 99: 1025-1031.