Lobectomy may not be suitable for patients with follicular neoplasm cytology

Background/aim: The most appropriate surgical management of follicular neoplasm/suspicious for follicular neoplasm FN lesions is still contradictory. We aimed to evaluate the data of our patients with follicular neoplasm treated with thyroidectomy. Materials and methods: We retrospectively analyzed the data of 74 patients who were diagnosed with follicular neoplasm cytology FN cytology by fine needle aspiration biopsy FNAB and had undergone total thyroidectomy or lobectomy with isthmectomy LwI . Results: We examineda total of 74 patients, of which 64 83.7% were female and 10 16.3% were male. The malignancy rate in the pathological examinations of these patients was 31/74 41.9% . The most common cancer among the patients with malignancy was papillary thyroid carcinomas PTC 20/31, 65% . Among the subtypes of PTCs, 11 were classical PTC, 5 were a follicular variant of PTC, 2 were the oncocytic variant of PTC, 1 was the diffuse sclerosing variant, and 1 was a columnar cell variant of PTC.Conclusion: Since most FN cytology has been pathologically diagnosed with papillary cancer and some papillary cancer subtypes have been unfavorable pathologically, total thyroidectomy should be the most suitable treatment option in this group. Lobectomy with LwI is not suitable for patients with FNAB-proven FN cytology.

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  • 1. Frates MC, Benson CB, Charboneau JW, Cibas ES, Clark OH, Coleman BG, Cronan JJ, Doubilet PM, Evans DB, Goellner JR et al. Management of thyroid nodules detected at the US: Society of Radiologists in ultrasound consensus conference statement. Ultrasound Q 2006; 22: 231-238.
  • 2. Mazzaferri EL. Management of a solitary thyroid nodule. N Engl J Med 1993; 328: 553-559.
  • 3. Baloch ZW, LiVolsi VA, Asa SL, Rosai J, Merino MJ, Randolph G, Vielh P, DeMay RM, Sidawy MK, Frable WJ. Diagnostic terminology and morphologic criteria for cytologic diagnosis of thyroid lesions: a synopsis of the National Cancer Institute Thyroid Fine-Needle Aspiration State of the Science Conference. Diagn Cytopathol 2008; 36: 425.
  • 4. Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL, McIver B, Pacini F, Schlumberger M et al. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 2009; 19: 1167-1214.
  • 5. Yoo C, Choi HJ, Im S, Jung JH, Min K, Kang CS, Suh YJ. Fine needle aspiration cytology of thyroid follicular neoplasm: cytohistologic correlation and accuracy. Korean J Pathol 2013 ; 47: 61-66.
  • 6. Bongiovanni M, Spitale A, Faquin WC, Mazzucchelli L, Baloch ZW. The Bethesda system for reporting thyroid cytopathology: a meta-analysis. Acta Cytol 2012; 56: 333-339.
  • 7. Wiseman SM, Baliski C, Irvine R, Anderson D, Wilkins G, Filipenko D, Zhang H, Bugis S. Hemithyroidectomy: the optimal initial surgical approach for individuals undergoing surgery for a cytological diagnosis of follicular neoplasm. Ann Surg Oncol 2006; 13: 425-432.
  • 8. Shah JP, Loree TR, Dharker D, Strong EW. Lobectomy versus total thyroidectomy for differentiated carcinoma of the thyroid: a matched-pair analysis. Am J Surg 1993; 166: 331-335.
  • 9. Conzo G, Calò PG, Gambardella C, Tartaglia E, Mauriello C, Della Pietra C, Medas F, Santa Cruz R, Podda F, Santini L et al. Controversies in the surgical management of thyroid follicular neoplasms. Retrospective analysis of 721 patients. Int J Surg 2014; 12: 29-34.
  • 10. Cibas ES, Ali SZ. NCI Thyroid FNA State of the Science Conference. The Bethesda system for reporting thyroid cytopathology. Am J Clin Pathol 2009; 132: 658-665.
  • 11. Antunes CM, Taveira-Gomes A. Lobectomy in follicular thyroid neoplasms’ treatment. Int J Surg 2013; 11: 919-922.
  • 12. Baloch ZW, Fleisher S, LiVolsi VA, Gupta PK. Diagnosis of ‘follicular neoplasm’: a gray zone in thyroid fine-needle aspiration cytology. Diagn Cytopathol 2002; 26: 41-44.
  • 13. Kim ES, Nam-Goong IS, Gong G, Hong SJ, Kim WB, Shong YK. Postoperative findings and risk for malignancy in thyroid nodules with cytological diagnosis of the so-called ‘follicular neoplasm’. Korean J Intern Med 2003; 18: 94-97.
  • 14. Spanheimer PM, Sugg SL, Lal G, Howe JR, Weigel RJ. Surveillance and intervention after thyroid lobectomy. Ann Surg Oncol 2011; 18: 1729-1733.
  • 15. Balentine CJ, Domingo RP, Patel R, Laucirica R, Suliburk JW. Thyroid lobectomy for indeterminate FNA: not without consequences. J Surg Res 2013; 184: 189-192.
  • 16. Bongiovanni M, Spitale A, Faquin WC, Mazzucchelli L, Baloch ZW. The Bethesda system for reporting thyroid cytopathology: a meta-analysis. Acta Cytol 2012; 56: 333-339.
  • 17. Al-Hureibi KA, Al-Hureibi AA, Abdulmughni YA, Aulaqi SM, Salman MS, Al-Zooba EM. The diagnostic value of fine needle aspiration cytology in thyroid swellings in a university hospital, Yemen. Saudi Med J 2003; 24: 499-450.
  • 18. Wu HH, Jones JN, Osman J. Fine-needle aspiration cytology of the thyroid: ten years’ experience in a community teaching hospital. Diagn Cytopathol 2006; 34: 93-96.
  • 19. Corso C, Gomez X, Sanabria A, Vega V, Dominguez LC, Osorio C. Total thyroidectomy versus hemithyroidectomy for patients with follicular neoplasm. A cost-utility analysis. Int J Surg 2014; 12: 837-842.
  • 20. Zanocco K, Heller M, Elaraj D, Sturgeon C. Cost-effectiveness of intraoperative pathology examination during diagnostic hemithyroidectomy for unilateral follicular thyroid neoplasms. J Am Coll Surg 2013; 217: 702-710.
  • 21. Gulcelik NE, Gulcelik MA, Kuru B. The risk of malignancy in patients with follicular neoplasm. Arch Otolaryngol Head Neck Surg 2008; 134: 1312-1315.
  • 22. Volante M, Landolfi S, Chiusa L, Palestini N, Motta M, Codegone A, Torchio B, Papotti MG. Poorly differentiated carcinomas of the thyroid with trabecular, insular and solid patterns: a clinicopathologic study of 183 patients. Cancer 2004; 100: 950-957.
Turkish Journal of Medical Sciences-Cover
  • ISSN: 1300-0144
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK
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