A Chlodowsky variant of generalized Szasz-type operators involving Boas-Buck-type polynomials is considered and some convergence properties of these operators by using a weighted Korovkin-type theorem are given. A Voronoskaja-type theorem is proved. The convergence properties of these operators in a weighted space of functions defined on $[0,\infty)$ are studied. The theoretical results are exemplified choosing the special cases of Boas-Buck polynomials, namely Appell-type polynomials, Laguerre polynomials, and Charlier polynomials.