Murat ÇALAPKULU, Muhammed Erkam SENCAR, İlknur ÖZTÜRK ÜNSAL, Hakan DÜĞER, Mustafa ÖZBEK, Erman ÇAKAL

Large ganglioneuroma case mimicking as an adrenal adenoma

Ganglioneuroma (GN) is a rarely seen benign tumor originating from neural crest cells and consisting of ganglion and Schwann cells. Adrenal GNs occur most frequently in the fourth and fifth decades of life. They have an equal frequency in male and female patients and are usually found incidentally during imaging. It is not related to hormonal activity and is clinically asymptomatic. We aimed to present a 49-year-old female patient whose magnetic resonance image performed for abdominal pain was found a biochemically normal mass in the right adrenal gland and then was pathologically diagnosed as GN after right adrenalectomy.

Keywords:

Adrenal ganglioneuroma, magnetic resonance imaging, adrenal adenoma, incidentaloma,

PDF

___

1. Joshi VV. Peripheral neuroblastic tumors: pathologic classification based on recommendations of international neuroblastoma pathology committee (Modification of shimada classification). Pediatr Dev Pathol Off J Soc Pediatr Pathol Paediatr Pathol Soc 2000;3(2):184–99.
2. Allende DS, Hansel DE, MacLennan GT. Ganglioneuroma of the Adrenal Gland. J Urol 2009;182(2):714–5.
3. Geoerger B, Hero B, Harms D, Grebe J, Scheidhauer K, Berthold F. Metabolic activity and clinical features of primary ganglioneuromas. Cancer 2001;91(10):1905–13.
4. Mylonas KS, Schizas D, Economopoulos KP. Adrenal ganglioneuroma: What you need to know. World J Clin Cases 2017;5(10):373–7.
5. Qing Y, Bin X, Jian W, et al. Adrenal ganglioneuromas: a 10-year experience in a Chinese population. Surgery 2010;147(6):854–60.
6. Shier KJ, Shaalan AK, Horn RC. Malignant Ganglioneuroma: Report of A Case of an Aggressively Growing Immature Ganglioneuroma. Can Med Assoc J 1961;85(3):135–9.
7. Inci I, Turgut M. Neurogenic tumors of the mediastinum in children. Childs Nerv Syst ChNS Off J Int Soc Pediatr Neurosurg 1999;15(8):372–6.
8. Mendelsohn G, Eggleston JC, Olson JL, Said SI, Baylin SB. Vasoactive intestinal peptide and its relationship to ganglion cell differentiation in neuroblastic tumors. Lab Investig J Tech Methods Pathol 1979;41(2):144–9.
9. Fassnacht M, Arlt W, Bancos I, et al. Management of adrenal incidentalomas: European Society of Endocrinology Clinical Practice Guideline in collaboration with the European Network for the Study of Adrenal Tumors. Eur J Endocrinol 2016;175(2):G1–34.
10. Sasaki S, Yasuda T, Kaneto H, et al. Large adrenal ganglioneuroma. Intern Med Tokyo Jpn 2012;51(17):2365–70.