Interferon gamma gene polymorphisms and chronic hepatitis B infections in Iranian population

Background/Aims: Chronic hepatitis B is an important health problem in all countries. Interferon gamma (IFN-γ) is a proinflammatory T-helper 1 cytokine, which can exert antiproliferative and antitumor activities. Some single nucleotide polymorphisms (SNPs) in IFN-γ and IFN-γ R1 genes may influence the susceptibility to hepatitis B virus (HBV). Here, we evaluated the impact of IFN-γ (+874 T/A) and its receptor (-611A/G, +189G/C, and +95C/T) polymorphisms and the risk of HBV in Iranian patients.Materials and Methods: SNPs of IFN-γ and its receptor genotypes were determined in 221 infected patients with HBV and 200 people without HBV using amplification-refractory mutation system polymerase chain reaction (PCR) and PCR restriction fragment length polymorphism method.Results: In this study, we showed an obvious relationship between IFN-γ SNPs and susceptibility to chronic HBV. Our findings suggest that IFN-γ-874A allele increases the risk of disease, and carriers of the T allele have reduced susceptibility to infection. In addition, there was no relationship between the -611A/G, +189G/C, and +95C/T regions of IFN-γ R1 and HBV.Conclusion: Our observations demonstrate +874 T/A SNP as a predicting factor in patients who have the risk of HBV.


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