Clinical comparative analysis of various duodenal diseases in different age groups

Background/Aims: This study aimed to investigate the differences and relevance of various common duodenal diseases in different parts in the aspects of age, gender, helicobacter pylori (H. pylori) infection, application of nonsteroidal anti-inflammatory drugs (NSAIDs), smoking, or alcohol consumption.Materials and Methods: The medical records of various duodenal diseases were collected and tested for difference using the χ2 test or the Fisher exact probability method.Results: 1) The proportions of duodenal ulcer (DU), inflammation, and duodenal bulb diseases in the adult group (A) (47.98%, 36.70%, and 66.63%) were higher than those in the elderly group (E) (41.38%, 29.83%, and 56.82%), but the proportions of duodenal diverticulum (DD) and tumor diseases in the descending and ascending segments (2.95%, 1.43%, 9.14%, and 0.14%) were lower than those in group E (13.73%, 3.69%, 19.41%, and 0.76%) (p


1. Srisajjakul S, Prapaisilp P, Bangchokdee S. Imaging spectrum of nonneoplastic duodenal diseases. Clin Imaging 2016; 40: 1173-81. [Crossref]

2. Lau JY, Barkun A, Fan DM, Kuipers EJ, Yang YS, Chan FK. Challenges in the management of acute peptic ulcer bleeding. Lancet 2013; 381: 2033-43. [Crossref]

3. Saul C, Teixeira CR, Pereira-Lima JC, Torresini RJ. [prevalence reduction of duodenal ulcer: a brazilian study. (retrospective analysis in the last decade: 1996-2005)]. Arq Gastroenterol 2007; 44: 320-4. [Crossref]

4. Leow AH, Lim YY, Liew WC, Goh KL. Time trends in upper gastrointestinal diseases and helicobacter pylori infection in a multiracial asian population - a 20-year experience over three time periods. Aliment Pharmacol Ther 2016; 43: 831-7. [Crossref]

5. Jiang JX, Liu Q, Mao XY, Zhang HH, Zhang GX, Xu SF. Downward trend in the prevalence of Helicobacter pylori infections and corresponding frequent upper gastrointestinal diseases profile changes in Southeastern China between 2003 and 2012. Springerplus 2016; 5: 1601. [Crossref]

6. Araújo MB, Borini P, Guimarães RC. Etiopathogenesis of peptic ulcer: back to the past? Arq Gastroenterol 2014; 51: 155-61. [Crossref]

7. Choninz D, Eisig J N, Cury M, Zaterka S. Úlcera péptica. In: Coelho JCU, editor. Aparelho digestivo: clínica e cirurgia. São Paulo: Ateneu, 2006; 522-43.

8. Sheh A, Fox JG. The role of the gastrointestinal microbiome in Helicobacter pylori pathogenesis. Gut Microbes 2013; 4: 505-31. [Crossref]

9. Selgrad M, Meyer F, Malfertheiner P. Helicobacter pylori: short overview on selected data from the history and their value for clinical medicine, in particular, surgery-what does the (general/abdominal) surgeon need to know. Zentralbl Chir 2014; 139: 399-405. [Crossref]

10. Dovjak P. [Duodenal ulcers, gastric ulcers and Helicobacter pylori]. Z Gerontol Geriatr 2017; 50: 159-69. [Crossref]

11. Chung CS, Chiang TH, Lee YC. A systematic approach for the diagnosis and treatment of idiopathic peptic ulcers. Korean J Intern Med 2015; 30: 559-70. [Crossref]

12. Yang YJ, Bang CS, Shin SP, et al. Clinical characteristics of peptic ulcer perforation in Korea. World J Gastroenterol 2017; 23: 2566-74. [Crossref]

13. Chan FKL, Ching JYL, Tse YK, et al. Strointestinal safety of celecoxib versus naproxen in patients with cardiothrombotic diseases and arthritis after upper gastrointestinal bleeding (CONCERN): an industry-independent, double-blind, double-dummy, randomised trial. Lancet 2017; 389: 2375-82. [Crossref]

14. Zil-E-Ali A, Bin Shafique M, Assad S, Ali H, Ghani U. A Non-invasive 24 Hours Stabilization of Duodenal Ulcer Perforation by a Combination Regimen. Cureus 2016; 8: e908. [Crossref]

15. Chinese Rheumatism Data Center; Chinese Systemic Lupus Erythematosus Treatment and Research Group. [Recommendation for the prevention and treatment of non-steroidal anti-inflammatory drug-induced gastrointestinal ulcers and its complications]. Zhonghua Nei Ke Za Zhi 2017; 56: 81-5.

16. Prabhu V, Shivani A. An overview of history, pathogenesis and treatment of perforated peptic ulcer disease with evaluation of prognostic scoring in adults. Ann Med Health Sci Res 2014; 4: 22-9. [Crossref]

17. Archampong TN, Asmah RH, Wiredu EK, Gyasi RK, Nkrumah KN. Factors associated with gastro-duodenal disease in patients undergoing upper GI endoscopy at the Korle-Bu Teaching Hospital, Accra, Ghana. Afr Health Sci 2016; 16: 611-9. [Crossref]

18. Wang YC. Medicinal plant activity on Helicobacter pylori related diseases. World J Gastroenterol 2014; 20: 10368-82. [Crossref]

19. Lahat A, Kopylov U, Neuman S, et al. Helicobacter pylori prevalence and clinical significance in patients with quiescent Crohn’s disease. BMC Gastroentero 2017; 17: 27. [Crossref]

20. Samsonov AA, Grechushnikov VB, Andreev DN, et al. Pharmacoeconomic evaluation of treatment in patients with Helicobacter pylori-associated diseases. Ter Arkh 2014; 86: 56-61.

21. Terada T. Pathologic observations of the duodenum in 615 consecutive duodenal specimens in a single Japanese hospital: II. malignant lesions. Int J Clin Exp Pathol 2012; 5: 52-7.

22. Glener J, Poris S, Foles B, Harmon R. Perforated duodenal diverticulum case report. Int J Surg Case Rep 2016; 29: 100-2. [Crossref]

23. Yeh TC. Laparoscopic resection of perforated duodenal diverticulum - A case report and literature review. Int J Surg Case Rep 2016; 28: 204-10. [Crossref]

24. Ekici Y, Moray G. Large Duodenal Diverticula Treated by Laparoscopic Surgical Excision: A Case Report. Invasive Surg 2015; 4: e30196. [Crossref]

25. Sorleto M, Timmer-Stranghöner A, Wuttig H, Engelhard O, Gartung C. Brunner’s Gland Adenoma - A Rare Cause of Gastrointestinal Bleeding: Case Report and Systematic Review. Case Rep Gastroenterol 2017; 11: 1-8. [Crossref]

26. Levine JA, Burgart LJ, Batts KP, Wang KK. Brunner’s gland hamartomas: clinical presentation and pathological features of 27 cases. Am J Gastroenterol 1995; 90: 290-4.

27. Ecker BL, McMillan MT, Datta J, et al. Adjuvant chemotherapy versus chemoradiotherapy in the management of patients with surgically resected duodenal adenocarcinoma: A propensity scorematched analysis of a nationwide clinical oncology database. Cancer 2016; 123: 967-76. [Crossref]

28. Knoop RF, Richter-Schrag HJ, Walker C, Thimme R, Fischer A. Double-scope resection of a large duodenal polyp. Endoscopy 2015; 47 Suppl 1: E627-8. [Crossref]

29. Yaman I, Derici H, Paksoy S. Symptomatic duodenal lipoma with endoscopic snare polypectomy. Ulus Cerrahi Derg 2014; 30: 103-5. [Crossref]

30. Zirpe D, Wani M, Tiwari P, Ramaswamy PK, Kumar RP. Duodenal Lipomatosis as a Curious Cause of Upper Gastrointestinal Bleed: A Report with Review of Literature. J Clin Diagn Res 2016; 10: PE01-4. [Crossref]

31. Nonaka S, Oda I, Tada K, et al. Clinical outcome of endoscopic resection for nonampullary duodenal tumors. Endoscopy 2015; 47: 129-35. [Crossref]

32. Cloyd JM, George E, Visser BC. Duodenal adenocarcinoma: Advances in diagnosis and surgical management. World J Gastrointest Surg 2016; 8: 212-21. [Crossref]

33. Jones JD, Oh S, Clark C, Pawa R. A Bleeding Duodenal GIST Masquerading as Refractory Peptic Ulcer Disease. ACG Case Rep J 2016; 3: e189. [Crossref]

34. Valli PV, Valli C, Pfammatter T, Bauerfeind P. Life-threatening bleeding of a duodenal gastrointestinal stromal tumor in a teenager: a rare case report. Endosc Int Open 2016; 4: E1244-6. [Crossref]

35. Zhong Y, Deng M, Liu B, Chen C, Li M, Xu R. Primary gastrointestinal stromal tumors: Current advances in diagnostic biomarkers, prognostic factors and management of its duodenal location. Intractable Rare Dis Res 2013; 2: 11-7. [Crossref]

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